The plant cell cycle: Pre-Replication complex formation and controls [PDF]
Genetics and Molecular Biology, 2017 The multiplication of cells in all living organisms requires a tight regulation of DNA replication. Several mechanisms take place to ensure that the DNA is replicated faithfully and just once per cell cycle in order to originate through mitoses two new ...
Juliana Nogueira Brasil +4 more
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A DNA replication-independent function of pre-replication complex genes during cell invasion in C. elegans. [PDF]
PLoS Biology, 2022 Cell invasion is an initiating event during tumor cell metastasis and an essential process during development. A screen of C. elegans orthologs of genes overexpressed in invasive human melanoma cells has identified several components of the conserved DNA
Evelyn Lattmann +10 more
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Chromatin’s Influence on Pre-Replication Complex Assembly and Function [PDF]
BiologyIn all eukaryotes, the initiation of DNA replication requires a stepwise assembly of factors onto the origins of DNA replication. This is pioneered by the Origin Recognition Complex, which recruits Cdc6.
Hina Ahmad +2 more
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Mutations in the pre-replication complex cause Meier-Gorlin syndrome. [PDF]
Nat Genet, 2011 Meier-Gorlin syndrome (ear, patella and short-stature syndrome) is an autosomal recessive primordial dwarfism syndrome characterized by absent or hypoplastic patellae and markedly small ears. Both pre- and post-natal growth are impaired in this disorder,
Bicknell LS +26 more
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Depletion of cellular pre-replication complex factors results in increased human cytomegalovirus DNA replication. [PDF]
PLoS ONE, 2012 Although HCMV encodes many genes required for the replication of its DNA genome, no HCMV-encoded orthologue of the origin binding protein, which has been identified in other herpesviruses, has been identified.
Tamara Evans Braun +2 more
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The role of DDK and Treslin–MTBP in coordinating replication licensing and pre-initiation complex formation [PDF]
Open Biology, 2021 Treslin/Ticrr is required for the initiation of DNA replication and binds to MTBP (Mdm2 Binding Protein). Here, we show that in Xenopus egg extract, MTBP forms an elongated tetramer with Treslin containing two molecules of each protein.
Ilaria Volpi +3 more
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Cdc6 ATPase activity disengages Cdc6 from the pre-replicative complex to promote DNA replication
eLife, 2015 To initiate DNA replication, cells first load an MCM helicase double hexamer at origins in a reaction requiring ORC, Cdc6, and Cdt1, also called pre-replicative complex (pre-RC) assembly.
FuJung Chang +6 more
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Control of pre-replicative complex during the division cycle in Chlamydomonas reinhardtii.
PLoS Genetics, 2021 DNA replication is fundamental to all living organisms. In yeast and animals, it is triggered by an assembly of pre-replicative complex including ORC, CDC6 and MCMs.
Amy E Ikui +3 more
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Reduced cohesin destabilizes high-level gene amplification by disrupting pre-replication complex bindings in human cancers with chromosomal instability. [PDF]
Nucleic Acids Res, 2016 Gene amplification is a hallmark of cancer with chromosomal instability although the underlying mechanism by which altered copy numbers are maintained is largely unclear.
Yun J +6 more
europepmc +2 more sources
The requirement of yeast replication origins for pre-replication complex proteins is modulated by transcription [PDF]
Nucleic Acids Research, 2005 The mini-chromosome maintenance proteins Mcm2–7 are essential for DNA replication. They are loaded onto replication origins during G1 phase of the cell cycle to form a pre-replication complex (pre-RC) that licenses each origin for subsequent initiation ...
Conrad A. Nieduszynski +2 more
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