Results 11 to 20 of about 510,232 (259)

Mcm3 Is Polyubiquitinated during Mitosis before Establishment of the Pre-replication Complex [PDF]

Journal of Biological Chemistry, 2002
To ensure fidelity in genome duplication, eukaryotes restrict DNA synthesis to once every cell division by a cascade of regulated steps. Central to this cascade is the periodic assembly of the hexameric MCM2–7 complex at replication origins.
Irene H. Cheng, Louis A. Roberts, Bik K. Tye   +2 more
openalex   +2 more sources

The Cyclin D1-dependent Kinase Associates with the Pre-replication Complex and Modulates RB·MCM7 Binding [PDF]

Journal of Biological Chemistry, 2003
The capacity of the cyclin D-dependent kinase to promote G1 progression through modulation of RB·E2F is well documented. We now demonstrate that the cyclin D1/CDK4 kinase binds to components of the MCM complex.
Andrew B. Gladden, J. Alan Diehl
openalex   +2 more sources

CDT1 is the major functional regulatory subunit of the pre-replication complex in zygotes. [PDF]

Cell Prolif, 2023
Li C, Tan YP, Ma XS, Wang ZB, Meng TG, Sun QY.   +5 more
europepmc   +2 more sources

Chromatin Remodeler Sucrose Nonfermenting 2 Homolog (SNF2H) Is Recruited onto DNA Replication Origins through Interaction with Cdc10 Protein-dependent Transcript 1 (Cdt1) and Promotes Pre-replication Complex Formation [PDF]

Journal of Biological Chemistry, 2011
Background: Cdt1 is a DNA replication factor that loads MCM helicase onto chromatin. SNF2H is a chromatin remodeler. Results: Recruitment of SNF2H to replication origins is Cdt1-dependent and promotes MCM loading.
Nozomi Sugimoto, Takashi Yugawa, Masayoshi Iizuka, Tohru Kiyono, Masatoshi Fujita   +4 more
openalex   +2 more sources

Selective interactions at pre-replication complexes categorize baseline and dormant origins [PDF]

Nature Communications
DNA synthesis in metazoans initiates within a select group of replication origins (baseline origins), whereas other (dormant) origins do not initiate replication despite recruiting apparently indistinguishable pre-replication complexes.
Bhushan L. Thakur, Christophe E. Redon, Haiqing Fu, Robin Sebastian, Nana A. Kusi, Sophie Z. Zhuang, Lorinc S. Pongor, Vilhelm A. Bohr, Mirit I. Aladjem   +8 more
doaj   +2 more sources

Structural mechanism of RPA loading on DNA during activation of a simple pre-replication complex [PDF]

EMBO Journal, 2006
Xiaohua Jiang, Vitaly Klimovich, Arun Alphonse Ignatius, Erik B. Hysinger, Yingda Wang, Robert Ott, Gulfem D. Guler, Brian Weiner, Walter Chazin, Ellen Fanning   +9 more
openalex   +2 more sources

Sap1 is a replication-initiation factor essential for the assembly of pre-replicative complex in the fission yeast Schizosaccharomyces pombe [PDF]

Journal of Biological Chemistry, 2017
A central step in the initiation of chromosomal DNA replication in eukaryotes is the assembly of pre-replicative complex (pre-RC) at late M and early G1 phase of the cell cycles.
Ling Guan, Peng He, Fang Yang, Yuan Zhang, Yunfei Hu, Jienv Ding, Hua Yu, Yi Zhang, Qiong Ye, Jiazhi Hu, Tao Wang, Changwen Jin, Daochun Kong   +12 more
openalex   +2 more sources

Comparative analysis of pre‐replication complex proteins in transformed and normal cells [PDF]

Journal of Cellular Biochemistry, 2011
Domenic Di Paola, Maria Zannis‐Hadjopoulos   +1 more
openalex   +2 more sources

Stability, chromatin association and functional activity of mammalian pre-replication complex proteins during the cell cycle [PDF]

EMBO Journal, 2001
Yukiko Okuno, Adrian J. McNairn, Nicole den Elzen, Jonathon Pines, David M. Gilbert   +4 more
openalex   +2 more sources

The human origin recognition complex is essential for pre-RC assembly, mitosis, and maintenance of nuclear structure

eLife, 2021
The origin recognition complex (ORC) cooperates with CDC6, MCM2-7, and CDT1 to form pre-RC complexes at origins of DNA replication. Here, using tiling-sgRNA CRISPR screens, we report that each subunit of ORC and CDC6 is essential in human cells. Using an
Hsiang-Chen Chou, Kuhulika Bhalla, Osama EL Demerdesh, Olaf Klingbeil, Kaarina Hanington, Sergey Aganezov, Peter Andrews, Habeeb Alsudani, Kenneth Chang, Christopher R Vakoc, Michael C Schatz, W Richard McCombie, Bruce Stillman   +12 more
doaj   +2 more sources