Results 11 to 20 of about 702,020 (309)

Chromatin’s Influence on Pre-Replication Complex Assembly and Function [PDF]

Biology
In all eukaryotes, the initiation of DNA replication requires a stepwise assembly of factors onto the origins of DNA replication. This is pioneered by the Origin Recognition Complex, which recruits Cdc6.
Hina Ahmad, Neha Chetlangia, Supriya G. Prasanth   +2 more
doaj   +6 more sources

The plant cell cycle: Pre-Replication complex formation and controls [PDF]

Genetics and Molecular Biology, 2017
The multiplication of cells in all living organisms requires a tight regulation of DNA replication. Several mechanisms take place to ensure that the DNA is replicated faithfully and just once per cell cycle in order to originate through mitoses two new ...
Juliana Nogueira Brasil, Carinne N. Monteiro Costa, Luiz Mors Cabral, Paulo C. G. Ferreira, Adriana S. Hemerly   +4 more
doaj   +7 more sources

Cdc6 ATPase activity disengages Cdc6 from the pre-replicative complex to promote DNA replication [PDF]

eLife, 2015
To initiate DNA replication, cells first load an MCM helicase double hexamer at origins in a reaction requiring ORC, Cdc6, and Cdt1, also called pre-replicative complex (pre-RC) assembly.
FuJung Chang, Alberto Riera, Cecile Evrin, Jingchuan Sun, Huilin Li, Christian Speck, Michael Weinreich   +6 more
doaj   +7 more sources

CDT1 is the major functional regulatory subunit of the pre-replication complex in zygotes. [PDF]

Cell Prolif, 2023
AbstractPre‐replication complex (pre‐RC) is critical for DNA replication initiation. CDT1 and MCM2 are the subunits of pre‐RC, and proper regulation of CDT1 and MCM2 are necessary for DNA replication and cell proliferation. The present study aimed to explore the role of CDT1 and MCM2 in oocyte meiotic maturation and early embryonic development.
Li C, Tan YP, Ma XS, Wang ZB, Meng TG, Sun QY.   +5 more
europepmc   +4 more sources

Mutations in the pre-replication complex cause Meier-Gorlin syndrome. [PDF]

Nat Genet, 2011
Meier-Gorlin syndrome (ear, patella and short-stature syndrome) is an autosomal recessive primordial dwarfism syndrome characterized by absent or hypoplastic patellae and markedly small ears¹⁻³. Both pre- and post-natal growth are impaired in this disorder, and although microcephaly is often evident, intellect is usually normal in this syndrome.
Bicknell LS, Bongers EM, Leitch A, Brown S, Schoots J, Harley ME, Aftimos S, Al-Aama JY, Bober M, Brown PA, van Bokhoven H, Dean J, Edrees AY, Feingold M, Fryer A, Hoefsloot LH, Kau N, Knoers NV, Mackenzie J, Opitz JM, Sarda P, Ross A, Temple IK, Toutain A, Wise CA, Wright M, Jackson AP.   +26 more
europepmc   +10 more sources

Depletion of cellular pre-replication complex factors results in increased human cytomegalovirus DNA replication. [PDF]

PLoS ONE, 2012
Although HCMV encodes many genes required for the replication of its DNA genome, no HCMV-encoded orthologue of the origin binding protein, which has been identified in other herpesviruses, has been identified.
Tamara Evans Braun, Emma Poole, John Sinclair   +2 more
doaj   +4 more sources

Control of pre-replicative complex during the division cycle in Chlamydomonas reinhardtii.

PLoS Genetics, 2021
DNA replication is fundamental to all living organisms. In yeast and animals, it is triggered by an assembly of pre-replicative complex including ORC, CDC6 and MCMs.
Amy E Ikui, Noriko Ueki, Kresti Pecani, Frederick R Cross   +3 more
doaj   +5 more sources

A DNA replication-independent function of pre-replication complex genes during cell invasion in C. elegans. [PDF]

PLoS Biology, 2022
Cell invasion is an initiating event during tumor cell metastasis and an essential process during development. A screen of C. elegans orthologs of genes overexpressed in invasive human melanoma cells has identified several components of the conserved DNA
Evelyn Lattmann, Ting Deng, Michael Walser, Patrizia Widmer, Charlotte Rexha-Lambert, Vibhu Prasad, Ossia Eichhoff, Michael Daube, Reinhard Dummer, Mitchell P Levesque, Alex Hajnal   +10 more
doaj   +2 more sources

Identification of ORC1/CDC6-interacting factors in Trypanosoma brucei reveals critical features of origin recognition complex architecture. [PDF]

PLoS ONE, 2012
DNA replication initiates by formation of a pre-replication complex on sequences termed origins. In eukaryotes, the pre-replication complex is composed of the Origin Recognition Complex (ORC), Cdc6 and the MCM replicative helicase in conjunction with ...
Calvin Tiengwe, Lucio Marcello, Helen Farr, Catarina Gadelha, Richard Burchmore, J David Barry, Stephen D Bell, Richard McCulloch   +7 more
doaj   +12 more sources

Dynamics of Pre-replicative Complex Assembly [PDF]

Journal of Biological Chemistry, 2010
The pre-replicative complex (pre-RC) is formed at all potential origins of replication through the action of the origin recognition complex (ORC), Cdc6, Cdt1, and the Mcm2-7 complex. The end result of pre-RC formation is the loading of the Mcm2-7 replicative helicase onto origin DNA.
Vasiliki Tsakraklides, Stephen P. Bell
openalex   +4 more sources