Results 21 to 30 of about 510,232 (259)

H3K9me3 demethylase Kdm4d facilitates the formation of pre-initiative complex and regulates DNA replication [PDF]

Nucleic Acids Research, 2016
DNA replication is tightly regulated to occur once and only once per cell cycle. How chromatin, the physiological substrate of DNA replication machinery, regulates DNA replication remains largely unknown. Here we show that histone H3 lysine 9 demethylase
Rentian Wu, Zhiquan Wang, Honglian Zhang, Haiyun Gan, Zhiguo Zhang   +4 more
openalex   +2 more sources

Aurora-A controls pre-replicative complex assembly and DNA replication by stabilizing geminin in mitosis [PDF]

Nature Communications, 2013
Geminin, an essential factor for DNA replication, directly binds to the licensing factor Cdt1 and inhibits pre-replicative complex formation to prevent re-replication.
Takaaki Tsunematsu, Yoshihiro Takihara, Naozumi Ishimaru, Michele Pagano, Takashi Takata, Yasusei Kudo   +5 more
openalex   +2 more sources

Genetic conservation of SARS-CoV-2 RNA replication complex in globally circulating isolates and recently emerged variants from humans and minks suggests minimal pre-existing resistance to remdesivir

bioRxiv, 2021
Ross Martin, Jiani Li, Aiyappa Parvangada, Jason K. Perry, Tomáš Cihlář, Hongmei Mo, Danielle Porter, Evguenia S. Svarovskaia   +7 more
openalex   +3 more sources

Pre-Replication Complex

Definitions, 2020
National Cancer Institute
openalex   +2 more sources

Phosphorylation of Mcm2 by Cdc7 Promotes Pre-replication Complex Assembly during Cell-Cycle Re-entry [PDF]

Molecules and Cells, 2009
Li-Chiou Chuang, Leonardo K. Teixeira, James A. Wohlschlegel, Martha Henze, John R. Yates, Juan Méndez, Steven I. Reed   +6 more
openalex   +2 more sources

Site-specific ORC binding, pre-replication complex assembly and DNA synthesis at Schizosaccharomyces pombe replication origins

EMBO Journal, 2002
Dong Kong
openalex   +2 more sources

Bioinformatical dissection of fission yeast DNA replication origins [PDF]

Open Biology, 2020
Replication origins in eukaryotes form a base for assembly of the pre-replication complex (pre-RC), thereby serving as an initiation site of DNA replication. Characteristics of replication origin vary among species.
Koji Masuda, Claire Renard-Guillet, Katsuhiko Shirahige, Takashi Sutani   +3 more
doaj   +1 more source

Pre-replication complex organization in the atypical DNA replication cycle of Plasmodium falciparum: Characterization of the mini-chromosome maintenance (MCM) complex formation

Molecular and biochemical parasitology (Print), 2005
Shelley Patterson, Claudia E. Robert, Christina M. Whittle, Ratna Chakrabarti, Christian Doerig, Debopam Chakrabarti   +5 more
openalex   +3 more sources

A Role of hIPI3 in DNA Replication Licensing in Human Cells. [PDF]

PLoS ONE, 2016
The yeast Ipi3p is required for DNA replication and cell viability in Sacharomyces cerevisiae. It is an essential component of the Rix1 complex (Rix1p/Ipi2p-Ipi1p-Ipi3p) that is required for the processing of 35S pre-rRNA in pre-60S ribosomal particles ...
Yining Huang, Aftab Amin, Yan Qin, Ziyi Wang, Huadong Jiang, Lu Liang, Linjing Shi, Chun Liang   +7 more
doaj   +1 more source

Chromosomal Mcm2-7 distribution and the genome replication program in species from yeast to humans.

PLoS Genetics, 2021
The spatio-temporal program of genome replication across eukaryotes is thought to be driven both by the uneven loading of pre-replication complexes (pre-RCs) across the genome at the onset of S-phase, and by differences in the timing of activation of ...
Eric J Foss, Smitha Sripathy, Tonibelle Gatbonton-Schwager, Hyunchang Kwak, Adam H Thiesen, Uyen Lao, Antonio Bedalov   +6 more
doaj   +1 more source