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Origin Recognition and Formation of Pre-Replicative Complex in Fission Yeast
Origin Recognition and Formation of Pre-Replicative Complex in Fission Yeastopenaire
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Eukaryotic DNA replication: from pre-replication complex to initiation complex
Current Opinion in Cell Biology, 2000A common mechanism has emerged for the control of the initiation of eukaryotic DNA replication. The minichromosome maintenance protein complex (MCM) and Cdc45 have now been recognized as central components of the initiation machinery. In addition, two types of S phase promoting kinases conserved between yeast and humans play critical roles in the ...
H, Takisawa, S, Mimura, Y, Kubota
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Norcantharidin Inhibits Pre-Replicative Complexes Assembly of HepG2 Cells
The American Journal of Chinese Medicine, 2013Norcantharidin (NCTD) is currently used for anticancer therapy but the exact mechanism of action remains unknown. Pre-replicative complexes (pre-RCs) are essential for cell DNA replication and highly related to malignant proliferation. Here, we examined the inhibitory effect of NCTD on pre-RC components in HepG2 cells.
Chen, S. +9 more
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Implication of Pre-replication Complex Proteins in Human Disease
2017Proper DNA replication is essential for the maintenance of genomic integrity during cell division. The DNA replication process in eukaryotes is an immaculately concerted and complex process that has evolved several safeguards to ensure the prevention and propagation of erroneous DNA duplication.
Abid Khan +2 more
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Recruitment of Xenopus Scc2 and cohesin to chromatin requires the pre-replication complex
Nature Cell Biology, 2004Cohesin is a multi-subunit, ring-shaped protein complex that holds sister chromatids together from the time of their synthesis in S phase until they are segregated in anaphase. In yeast, the loading of cohesin onto chromosomes requires the Scc2 protein.
Tatsuro S, Takahashi +4 more
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XCDT1 is required for the assembly of pre-replicative complexes in Xenopus laevis
Nature, 2000In eukaryotic cells, chromosomal DNA replication begins with the formation of pre-replication complexes at replication origins. Formation and maintenance of pre-replication complexes is dependent upon CDC6 (ref. 1), a protein which allows assembly of MCM2-7 proteins, which are putative replicative helicases. The functional assembly of MCM proteins into
D, Maiorano, J, Moreau, M, Méchali
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Involvement of human ORC and TRF2 in pre‐replication complex assembly at telomeres
Genes to Cells, 2008The origin recognition complex (ORC) binds to replication origins to regulate the cell cycle‐dependent assembly of pre‐replication complexes (pre‐RCs). We have found a novel link between pre‐RC assembly regulation and telomere homeostasis in human cells.
Yasutoshi, Tatsumi +8 more
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