Results 111 to 120 of about 127,576 (188)

A Conserved Deubiquitinating Enzyme Controls Cell Growth by Regulating RNA Polymerase I Stability

Cell Reports, 2012
Eukaryotic ribosome biogenesis requires hundreds of trans-acting factors and dozens of RNAs. Although most factors required for ribosome biogenesis have been identified, little is known about their regulation.
Lauren A. Richardson, Benjamin J. Reed, J. Michael Charette, Emily F. Freed, Eric K. Fredrickson, Melissa N. Locke, Susan J. Baserga, Richard G. Gardner   +7 more
doaj   +1 more source

Rcl1 depletion impairs 18S pre-rRNA processing at the A1-site and up-regulates a cohort of ribosome biogenesis genes in zebrafish. [PDF]

Nucleic Acids Res, 2021
Zhu Q, Tao B, Chen H, Shi H, Huang L, Chen J, Hu M, Lo LJ, Peng J.   +8 more
europepmc   +1 more source

Mutations in Mtr4 Structural Domains Reveal Their Important Role in Regulating tRNA\u3csub\u3ei\u3c/sub\u3e \u3csup\u3eMet\u3c/sup\u3e Turnover in \u3cem\u3eSaccharomyces cerevisiae\u3c/em\u3e and Mtr4p Enzymatic Activities \u3cem\u3eIn Vitro\u3c/em\u3e [PDF]

, 2016
RNA processing and turnover play important roles in the maturation, metabolism and quality control of a large variety of RNAs thereby contributing to gene expression and cellular health.
Anderson, James T., Burclaff, Joseph, Li, Yan   +2 more
core   +1 more source

An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations. [PDF]

, 2019
Parietal cortex RNA-sequencing (RNA-seq) data were generated from individuals with and without Alzheimer disease (AD; ncontrol = 13; nAD = 83) from the Knight Alzheimer Disease Research Center (Knight ADRC).
Bateman, Randall J, Budde, John P, Chhatwal, Jasmeer P, Cruchaga, Carlos, Del-Aguila, Jorge L, Dominantly Inherited Alzheimer Network (DIAN), Dube, Umber, Farias, Fabiana, Fernandez, Maria Victoria, Gentsch, Jen, Graff-Radford, Neill R, Harari, Oscar, Hsu, Simon, Ibanez, Laura, Jiang, Shan, Karch, Celeste M, Lee, Jae-Hong, Li, Zeran, Masters, Colin L, Morris, John C, Norton, Joanne, Salloway, Stephen, Wang, Fengxian   +22 more
core  

Synergistic defects in pre-rRNA processing from mutations in the U3-specific protein Rrp9 and U3 snoRNA. [PDF]

Nucleic Acids Res, 2020
Clerget G, Bourguignon-Igel V, Marmier-Gourrier N, Rolland N, Wacheul L, Manival X, Charron C, Kufel J, Méreau A, Senty-Ségault V, Tollervey D, Lafontaine DLJ, Branlant C, Rederstorff M.   +13 more
europepmc   +1 more source

Nucleolar localization of the yeast RNA exosome subunit Rrp44 hints at early pre-rRNA processing as its main function. [PDF]

J Biol Chem, 2020
Okuda EK, Gonzales-Zubiate FA, Gadal O, Oliveira CC.   +3 more
europepmc   +1 more source

Loss of The RNA Helicase SKIV2L2 Impairs Mitotic Progression and Replication-Dependent Histone mRNA Turnover in Murine Cell Lines [PDF]

, 2017
RNA surveillance via the nuclear exosome requires cofactors such as the helicase SKIV2L2 to process and degrade certain noncoding RNAs. This research aimed to characterize the phenotype associated with RNAi knockdown of Skiv2l2 in two murine cancer cell ...
Anderson, James T., Onderak, Alexis Marie   +1 more
core   +1 more source

GABA-modulating bacteria of the human gut microbiota. [PDF]

, 2019
The gut microbiota affects many important host functions, including the immune response and the nervous system1. However, while substantial progress has been made in growing diverse microorganisms of the microbiota2, 23-65% of species residing in the ...
Clardy, Jon, Dietrich, David, Dubin, Marc J, Gilbert, Jack A, Kim, Ki Hyun, Knight, Rob, Lekbua, Asama, Levering, Jennifer, Lewis, Kim, Liston, Conor, Liu, Joanne K, McDonald, Daniel, Mroue, Nader, Ramadhar, Timothy R, Sharma, Anukriti, Stewart, Eric J, Strandwitz, Philip, Terekhova, Darya, Zengler, Karsten   +18 more
core  

Cryo-EM reveals active site coordination within a multienzyme pre-rRNA processing complex. [PDF]

Nat Struct Mol Biol, 2019
Pillon MC, Hsu AL, Krahn JM, Williams JG, Goslen KH, Sobhany M, Borgnia MJ, Stanley RE.   +7 more
europepmc   +1 more source

RPSA, a candidate gene for isolated congenital asplenia, is required for pre-rRNA processing and spleen formation in Xenopus. [PDF]

Development, 2018
Griffin JN, Sondalle SB, Robson A, Mis EK, Griffin G, Kulkarni SS, Deniz E, Baserga SJ, Khokha MK.   +8 more
europepmc   +1 more source