Results 121 to 130 of about 14,806,844 (291)

Study of fluoroquinolones resistance in rifampicin‐resistant tuberculosis patients in Beijing: Characteristics, trends, and treatment outcomes

Animal Models and Experimental Medicine
Background China is a high‐burden country for multidrug‐resistant tuberculosis/rifampin‐resistant tuberculosis (MDR/RR‐TB). Fluoroquinolones (FQs) are key drugs for the treatment of patients with MDR/RR‐TB.
Wang Nenhan, Tian Lili, Zhao Yanfeng, Chen Shuangshuang, Tao LiYing, Li Qiao, Li Chuanyou, Dai Xiaowei   +7 more
doaj   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Implementation of a National Anti-Tuberculosis Drug Resistance Survey in Tanzania. [PDF]

, 2008
A drug resistance survey is an essential public health management tool for evaluating and improving the erformance of National Tuberculosis control programmes.
Mfaume, Saidi M, Range Nyagosya, Mfaume, Saidi M., Cobelens Frank G, Chonde Timothy M, Mfinanga Sayoki GM, Egwaga Saidi M, Lwilla, F., Mfinanga, Sayoki G M, van Leth, Frank, Zignol, M., van Leth, F., Doulla Basra, Van Deun, A., Mfaume, S. M., Doulla, Basra, Range, Nyagosya, Mfaume Saidi M, van Deun Armand, Chonde, Timothy M, Range, N., Mfinanga, S. G. M., Chonde, Timothy M., van Leth Frank, Cobelens, F. G., van Deun, Armand, Egwaga, Saidi M, Cobelens, Frank G., Lwilla Fred, Chonde, T. M., Zignol Matteo, Egwaga, S. M., Mfinanga, Sayoki G. M., Doulla, B., Cobelens, Frank G, Egwaga, Saidi M., Zignol, Matteo, Lwilla, Fred   +37 more
core   +1 more source

Whole genome sequencing-based detection of extensively drug-resistant tuberculosis from Ethiopia

Communications Medicine
Background Rapid and accurate detection of extensively drug-resistant tuberculosis is crucial for effective intervention. Next-generation sequencing technologies have been recommended to rapidly and accurately detect resistance to second-line anti-TB ...
Getu Diriba, Hilina Mollalign, Abyot Meaza, Melak Getu, Betselot Zerihun, Ayinalem Alemu, Biniyam Dagne, Yeshiwork Abebaw, Atsbaha Gebreegziabxier Weldemariam, Chala Bashea, Abraham Ali, Getachew Seid, Muluwork Getahun, Michael Hailu, Amanuel Wondimu, Tsegaye Getachew, Andargachew Kumsa, Taye Letta, Atlabachew Liaulseged, Negga Asamene Abera, Zelalem Abate, Ephrem Alemu, Feyissa Challa, Gemechu Tadesse, Saro Abdella, Getachew Tollera, Mesay Hailu Dangisso   +26 more
doaj   +1 more source

Second-line drug resistance among multidrug-resistant tuberculosis patients in Ethiopia: A laboratory-based surveillance

Journal of Global Antimicrobial Resistance
Objectives: To estimate the proportion of second-line anti-tuberculosis drug resistance among multidrug-resistant tuberculosis (MDR-TB) patients in Ethiopia.
Getu Diriba, Ayinalem Alemu, Bazezew Yenew, Betselot Zerihun Ayano, Michael Hailu, Bedo Buta, Amanuel Wondimu, Zigba Tefera, Abyot Meaza, Getachew Seid, Muluwork Getahun, Biniyam Dagne, Hilina Mollalign, Yeshiwork Abebaw, Melak Getu, Mengistu Tadesse, Tegegn Belhu, Ephrem Alemu, Minilik Demissie, Ashenafi Erresso, Getachew Aga, Andargachew Kumsa, Taye Letta, Saro Abdella, Shewki Moga, Mesay Hailu Dangisso, Getachew Tollera, Gemechu Tadesse   +27 more
doaj   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Antimalarial drug resistence and artemisinin based combination therapy : a bio-economic model for elucidating policy choices [PDF]

Antimalarial drug resistance is a major cause of the increasing burden due to P. falciparum malaria. Artemisinin-based combination therapies (ACTs) are now recognised to be the ideal choice for the first-line treatment of ...
Yeung, Shunmay
core   +1 more source

Metabolic-Temporal Dissociation: A Kinetic Framework for Pre-Treatment Drug Resistance

This preprint introduces the Metabolic-Temporal Dissociation (MTD) framework (v3.0), a multi-tier quantitative model proposing a microenvironment-driven, deterministic kinetic mechanism for the emergence of EGFR T790M gatekeeper resistance mutations in treatment-naive lung adenocarcinomas.
openaire   +2 more sources

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

New approaches to measuring anthelminthic drug efficacy : parasitological responses of childhood schistosome infections to treatment with praziquantel [PDF]

, 2015
By 2020, the global health community aims to control and eliminate human helminthiases, including schistosomiasis in selected African countries, principally by preventive chemotherapy (PCT) through mass drug administration (MDA) of anthelminthics ...
Scherrer, A U, Raso, G, Utzinger, Jürg, Alexandra U. Scherrer, King, Charles H., Coulibaly, Jean T., Walker, Martin, Basanez, MG, Jean T. Coulibaly, Basáñez, M-G, King, CH, Martin Walker, Walker, M, Scherrer, Alexandra U., Sousa-Figueiredo, José Carlos, Katarina Stete, Mabud, Tarub S., Mabud, T, Stete, Katarina, Basáñez, Maria-Gloria, Coulibaly, J T, José Carlos Sousa-Figueiredo, Jürg Utzinger, Maria-Gloria Basáñez, Utzinger, J, Giovanna Raso, Scherrer, AU, Raso, Giovanna, Olliaro, Piero L., Stothard, JR, Stothard, J R, Sousa-Figueiredo, J C, Olliaro, PL, Coulibaly, JT, Sousa-Figueiredo, JC, Stothard, J. Russell, Charles H. King, King, C H, J. Russell Stothard, Tarub S. Mabud, Piero L. Olliaro, Olliaro, P L, Stete, K   +42 more
core   +1 more source