Results 131 to 140 of about 14,806,844 (291)

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Rapid microarray-based method for monitoring of all currently known single-nucleotide polymorphisms associated with parasite resistance to antimalaria drugs. [PDF]

, 2007
Parasite drug resistance is partly conferred by single-nucleotide polymorphisms (SNPs), and monitoring them has been proposed as an alternative to monitoring drug resistance.
Regös, Attila, Beck, Hans-Peter, Puijalon, Odile, Huber, E., Crameri, A., Regos, A., Crameri, Andreas, Mugittu, K., Felger, Ingrid, Sismeiro, Odile, Laubscher, Daniel, Marfurt, J., Genton, B., Laubscher, D., Puijalon, O., Felger, I., Burki, Richard, Beck, H. P., Coppee, Jean Yves, Genton, Blaise, Maire, N., Coppee, J. Y., Marfurt, Jutta, Mugittu, Kefas, Maire, Nicolas, Burki, R., Huber, Eric, Sismeiro, O.   +27 more
core   +1 more source

Impact of HIV Pretreatment Drug Resistance on Secondary Transmission Through Treatment Dropout: A Prospective Population-Based Study in Southwestern China

Infection and Drug Resistance
Yi Chen,1,* Xiaoshan Xu,2,* Huanhuan Chen,3,* Xiangjun Zhang,4 Qiuying Zhu,3 Shujia Liang,3 Hui Xing,2 Lingjie Liao,2 Yi Feng,2 Yiming Shao,2 Yuhua Ruan,2 Guanghua Lan,3 Jianjun Li3 1The Guangxi Academy of Medical Sciences, The ...
Chen Y, Xu X, Chen H, Zhang X, Zhu Q, Liang S, Xing H, Liao L, Feng Y, Shao Y, Ruan Y, Lan G, Li J   +12 more
doaj  

Whole genome sequencing reveals novel resistance-conferring mutations and large genome deletions in drug-resistant Mycobacterium tuberculosis isolates from Indonesia

Journal of Global Antimicrobial Resistance
Objective: This study evaluated drug resistance profiles of Mycobacterium tuberculosis (Mtb) isolates in West Java, Indonesia through phenotypic and genomic approaches.
Htin Lin Aung, Lidya Chaidir, Dian Ayu Eka Pitaloka, Yugen Miyahara, Narender Kumar, Arto Yuwono Soeroto, Greg M Cook, Reinout van Crevel, Bachti Alisjahbana, Sharon J. Peacock, Philip C Hill   +10 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

Monitoring for multidrug-resistant Plasmodium falciparum isolates and analysis of pyrimethamine resistance evolution in Uige province, Angola.

, 2009
OBJECTIVES: To assess the extent of drug resistance in Uige through molecular genetic analysis and to test whether the dhfr triple mutant alleles present in Angola are of southeast Asian origin.
Inojosa WO, Roper C, Bisoffi, Zeno, Bisoffi Z, Ord, Rosalynn, Roper, Cally, Abel PM, Severini C, Pisani, Vincenzo, Matondo A, Warhurst DC, Pisani V, Pearce RJ, Matondo, Alexandre, Warhurst, David C, Severini, Carlo, Menegon M, Menegon, Michela, Inojosa, Walter O, Abel, Paulo M, Majori, Giancarlo, Majori G, Ord R, Pearce, Richard J   +23 more
core   +1 more source

Acute Kidney Injury After Mechanical Thrombectomy for Stroke in Patients With Pre‐Existing Renal Impairment

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Acute kidney injury (AKI) is a common but often underrecognized complication in ischemic stroke patients undergoing mechanical thrombectomy, particularly among those with pre‐existing renal impairment. This study evaluated the incidence, risk factors, and clinical impact of AKI in this high‐risk population.
Michał Borończyk, Marcel Pilarek, Emilia Jaworska, Natalia Kardas, Oliwia Barnaś, Julia Woźniak, Iga Machała, Julia Węgrzynek‐Gallina, Joanna Siuda, Anna Hawrot‐Kawecka, Anetta Lasek‐Bal   +10 more
wiley   +1 more source

Screening Routine Clinical Notes for Epilepsy Surgery Candidates Using Large Language Models

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epilepsy surgery is severely underutilized despite proven efficacy, with substantial under‐referral of eligible patients in routine clinical practice. This study evaluated the potential role of large language models (LLMs) as decision‐support tools for screening unstructured clinical notes to identify epilepsy surgery candidates and ...
Uriel Fennig, Nadav Amir, Maya Schiller, Roni Loebenstein, Johnatan Nissan, Marina Boxer, Shany Guly Gofrit, Gal Goshen, Sándor Beniczky, Nicola Maggio   +9 more
wiley   +1 more source

Pre-treatment HIV-1 drug resistance in Cuban patients with late presentation to health care: 2009-2020.

Journal of Microbiology and Infectious Diseases
Background: The presence of antiretroviral-resistant HIV-1 genetic variants in patients with late presentation to health care may impact the success of antiretroviral therapy, costs of care, and potential HIV transmission. Aim: To determine the prevalence of pre-treatment HIV-1 drug resistance to antiretrovirals (PDR) in Cuban patients classified as ...
Liuber Machado, H az, Liodelvio nez, Madeline Blanco, Marta Dubed, Neisy s, Karen s, Laura pez, Enrique Noa, Mar rez, Otto Cruz, Mireida guez   +11 more
openaire   +1 more source