Results 101 to 110 of about 2,498,929 (340)

On Some Aspects of the Participation of Experts and Specialists in Criminal Proceedings in the Republic of Kazakhstan

Теория и практика судебной экспертизы
The article considers particular reasons for the start of a pre-trial investigation, which are associated with the participation of persons having specialized knowledge in the proceedings.By using a number of methods of cognition of the circumstances of ...
K. K. Seitenov, A. Z. Saken
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Historical background to the formation of the forensic doctrine on neutralising investigation counteraction

Bulletin of Kharkiv National University of Internal Affairs
The article substantiates that in the course of historical development of mankind, counteraction to an investigation naturally accompanies such a form of social activity as criminal activity, and therefore, is a substantive component of criminal activity.
O. M. Tarkan
doaj   +1 more source

Early Settlement in European Merger Control [PDF]

, 2016
We analyse the determinants of early settlement between merging parties and the European Commission over remedies that remove concerns of anticompetitive effects.
Aktas, Ashenfelter, Ausubel, Baker, Bebchuk, Bergman, Bougette, Bourjade, Coate, Coate, Coate, Coate, Cooter, Cramton, Davies, Davies, Davies, Dougherty, Duso, Fenn, Fenn, Fenn, Fernández, Fournier, Fournier, Friedman, Fudenberg, Grossman, Ivaldi, Kennan, Kessler, Kessler, Kouliavtsev, Kühn, Lindsay, Lyons, Ormosi, Perloff, Priest, Reinganum, Sobel, Spier, Spier, Ven, Waldfogel   +44 more
core   +1 more source

Features of Criminal Proceedings (Pre-Trial and Trial Investigation) in the Time of Pandemic Covid-19

, 2020
The work is devoted to the main problems and features that have emerged in the field of criminal justice (pre-trial investigation and trial) in a pandemic.
L. Bielik, O. Samoilenko, H. Mudretska, T. Voloshanivska, Kateryna Titunina   +4 more
semanticscholar   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Деякі аспекти забезпечення прав учасників кримінального провадження під час ознайомлення з матеріалами досудового розслідування [PDF]

, 2015
Паршак, С. А. Деякі аспекти забезпечення прав учасників кримінального провадження під час ознайомлення з матеріалами досудового розслідування / Паршак Сергій Анатолійович // Наше право. - 2015. - № 4. - С. 126-130.Паршак С. А. "Деякі аспекти забезпечення
Parshak, S. A., Паршак, С. А.
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Disclosure of evidence in pre-trial proceedings and investigation [PDF]

Strani pravni život, 2020
Disclosure of evidence to the defendant and defense counsel during pre-trial proceedings and investigations is important for the defendant to be able to devise a defense strategy and to suggest the taking of other evidentiary actions during the ...
Živković Natalija M.
doaj