Results 61 to 70 of about 77,082 (360)

Achieving Optimal Health With Host‐Directed Therapies (HDTs) in Infectious Diseases—A New Horizon

Advanced Therapeutics, EarlyView.
Host‐directed therapies (HDTs) represent a transformative approach in infectious disease management by targeting host factors to enhance immune responses and inhibit viral replication. This innovative strategy leverages advanced genomics and gene editing technologies, offering promising avenues for improved patient outcomes and a new horizon in ...
Amol D. Gholap, Pankaj R. Khuspe, Sagar R. Pardeshi, Md Jasim Uddin, Ushasi Das, Navnath T. Hatvate, Satish Rojekar, Prabhanjan Giram, Mohammad Khalid, Yahya E. Choonara, Md. Faiyazuddin   +10 more
wiley   +1 more source

Prebiotic, probiotic and symbiotic as alternative to Antibiotics on the Performance and Immune Response of Broiler Chickens

Brazilian Journal of Poultry Science, 2014
This study aimed to evaluate diets supplemented with prebiotic, probiotic and symbiotic as an alternative to antibiotics on the performance and immune response against the virus of Newcastle disease in broiler chickens.
VDA Murarolli, MFC Burbarelli, GV Polycarpo, PAP Ribeiro, MEG Moro, R Albuquerque   +5 more
doaj   +1 more source

Scum of the Earth: A Hypothesis for Prebiotic Multi-Compartmentalised Environments

Life, 2021
Compartmentalisation by bioenergetic membranes is a universal feature of life. The eventual compartmentalisation of prebiotic systems is therefore often argued to comprise a key step during the origin of life.
Craig Robert Walton, Oliver Shorttle
doaj   +1 more source

Administration of galacto-oligosaccharide prebiotics in the Flinders Sensitive Line animal model of depression [PDF]

, 2019
INTRODUCTION: Major depressive disorder is the leading source of disability globally and current pharmacological treatments are less than adequate. Animal models such as the Flinders Sensitive Line (FSL) rats are used to mimic aspects of the phenotype in
Bannach-Brown, Alexandra, Macleod, Malcolm R., Tillmann, Sandra, Wegener, Gregers   +3 more
core   +1 more source

Correlation Between Fecal Microbiota and Corticosteroid Responsiveness in Primary Immune Thrombocytopenia: an Exploratory Study

Advanced Science, EarlyView.
This study uses gut microbiome data to predict corticosteroid response in patients with immune thrombocytopenia (ITP). Fecal samples from 212 patients with ITP are sequenced. Six machine‐learning algorithms are used to train predictive models. The support vector machine‐based model integrated clinical data and selected microbial species, diversities ...
Feng‐Qi Liu, Zhuo‐Yu An, Li‐Juan Cui, Meng‐Yu Xiao, Ye‐Jun Wu, Wei Li, Bang‐Shuo Zhang, Li Yu, Jia Feng, Zhuo‐Gang Liu, Ru Feng, Zhong‐Xing Jiang, Rui‐Bin Huang, Hong‐Mei Jing, Jin‐Hai Ren, Xiao‐Yu Zhu, Yun‐Feng Cheng, Yu‐Hua Li, He‐Bing Zhou, Da Gao, Yi Liu, Fan Yu, Xin Wang, Jian‐Lin Qiao, Dai‐Hong Hu, Lu‐Lu Wang, Meng‐Tong Zang, Qi Chen, Qing‐Yuan Qu, Jian‐Ying Zhou, Meng‐Lin Li, Yu‐Xiu Chen, Qiu‐Sha Huang, Hai‐Xia Fu, Yue‐Ying Li, Qian‐Fei Wang, Xiao‐Jun Huang, Xiao‐hui Zhang, the Cooperative ITP Working Group   +38 more
wiley   +1 more source

Pressure‐Driven Reactivity in Dense Methane‐Nitrogen Mixtures

Angewandte Chemie, EarlyView.
CH4 and N2 are abundant molecules in our solar system and are the primary constituents of Titan's atmosphere. Under extreme pressures and temperatures within a diamond anvil cell, CH4 and N2 are demonstrated to react to form a range of compounds, dependent on the conditions and initial concentrations.
Hannah A. Shuttleworth, Mikhail A. Kuzovnikov, Lewis J. Conway, Huixin Hu, Jinwei Yan, Samuel Gallego‐Parra, Israel Osmond, Tomas Marqueño, Michael Hanfland, Dominique Laniel, Eugene Gregoryanz, Andreas Hermann, Miriam Peña‐Alvarez, Ross T. Howie   +13 more
wiley   +2 more sources

The effects of different levels of dietary prebiotic on growth performance and some non-specific immune parameters in zebra fish (Danio rerio) [PDF]

بوم‌شناسی آبزیان, 2017
The aim of the present study was to evaluate the effects of different levels of prebiotic on growth performance and non-specific immune parameters of zebra fish.
Samira Yousefi, Seyed Hossein Hoseinifar, Abdolmajid Hajimoradloo, Hamed Kolangi Miandare   +3 more
doaj  

Orally Administered Functional Polyphenol‐Nanozyme‐Armored Probiotics for Enhanced Amelioration of Intestinal Inflammation and Microbiota Dysbiosis

Advanced Science, EarlyView.
This study presents a novel polyphenol‐nanozyme‐armored probiotic system (ECA@EcN) for enhanced treatment of inflammatory bowel disease (IBD). By integrating chitosan‐modified epigallocatechin gallate (EGCG‐CS) with gold nanozymes, the system effectively scavenges ROS, improves probiotic viability, and restores gut microbiota balance.
Yong Zhu, Ziqu Fang, Jie Bai, Longhui Wang, Jiaqing Chen, Zehua Zhang, Qiang Wang, Weiwei Sheng, Xueyin Pan, Zhenyuan Gao, Dengqiu Xu, Pengkai Wu, Beicheng Sun   +12 more
wiley   +1 more source

A Sequential Release Micro‐nano System for Colitis Therapy via Gut Microbiota and Immune Regulation

Angewandte Chemie, EarlyView.
The micro‐nano system achieves the sequential release of drugs in response to gut microbiota and reactive oxygen species (ROS). Inulin prebiotics restore gut microbiota balance. Selenium compounds scavenge ROS and promote macrophage polarization, while 3‐oxolithocholic acid suppresses TH17‐cell differentiation. As a multifactorial therapeutic approach,
Dongdong Zhu, Xiaocao Ma, Jingguo Wang, Tiantian Chen, Jiahui Yang, Yan Liu, Zhun Lin, Minhao Wu, Tony Y. Hu, Yuanqing Zhang   +9 more
wiley   +2 more sources

Toward homochiral protocells in noncatalytic peptide systems

, 2009
The activation-polymerization-epimerization-depolymerization (APED) model of Plasson et al. has recently been proposed as a mechanism for the evolution of homochirality on prebiotic Earth.
A Brack, A Brandenburg, A Brandenburg, A Commeyras, A Lazcano, B-M Rode, C Shen, C Viedma, CJ Welch, D Castelvecchi, D Deamer, D Deamer, D Deamer, D Segrè, D-G Blackmond, D-K Kondepudi, F-C Frank, G Wächtershäuser, G-F Joyce, G-F Joyce, H-J Morowitz, J-A Wattis, J-D Gunton, J-S Langer, J-W Szostak, JD Dunitz, K Soai, L Leman, M Fishkis, M Gleiser, M Gleiser, M Gleiser, M Huber, M Huber, M Reches, M Reches, M-P Robertson, Marcelo Gleiser, N Berclaz, N Berclaz, P-A Monnard, P-G-H Sandars, R Cotterill, R Lathe, R Lathe, R Plasson, R-M Smith, R-P Bywater, S Fox, S Fox, S Fox, S Lonchin, S Rasmussen, S Santoso, S Vauthey, S-L Miller, Sara Imari Walker, UJ Meierhenrich, V-A Avetisov, W-A Bonner, Y Saito, Y Saito   +61 more
core   +1 more source