Results 51 to 60 of about 50,740 (306)

Scum of the Earth: A Hypothesis for Prebiotic Multi-Compartmentalised Environments

Life, 2021
Compartmentalisation by bioenergetic membranes is a universal feature of life. The eventual compartmentalisation of prebiotic systems is therefore often argued to comprise a key step during the origin of life.
Craig Robert Walton, Oliver Shorttle
doaj   +1 more source

A prebiotic precursor to Life’s phosphate transfer system with an ATP analogue and histidyl peptide organocatalysts

, 2023
Biochemistry is dependent upon enzyme catalysts accelerating key reactions. At the origin of life, prebiotic chemistry must have incorporated catalytic reactions.
Iris B. A., Smokers, Bob G., Oosterom, Oliver R., Maguire, Alla, Zheliezniak, Wilhelm T. S., Huck   +4 more
core   +1 more source

Gastrointestinal effects of prebiotics [PDF]

British Journal of Nutrition, 2002
The defining effect of prebiotics is to stimulate selectively the growth of bifidobacteria and lactobacilli in the gut and, thereby, increase the body's natural resistance to invading pathogens. Prebiotic carbohydrates may also have additional, less specific, benefits because they are fermented in the large intestine.
J H, Cummings, G T, Macfarlane
openaire   +2 more sources

Icariin Enhances the Enzymatic Activity of N‐acetylgalactosaminidase to Augment Akkermansia Abundance in Gut Microbiota for Improved PD‐1 Blockade Efficacy in Tumor Suppression

Advanced Science, EarlyView.
Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao, Liu Yang, Haibang Hao, Qiuxia Ding, Feng Ding, Zheng Chen, Jinfang Zhang, Yun He, Meng Li, Jun Xu, Chao Wang, Aiping Lu, Fangfei Li   +12 more
wiley   +1 more source

Can synthetic biology shed light on the origin of life? [PDF]

, 2009
It is a most commonly accepted hypothesis that life originated from inanimate matter, somehow being a synthetic product of organic aggregates, and as such, a result of some sort of prebiotic synthetic biology.
Malaterre, Christophe
core  

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Enhancing Broiler Growth Performance and Gut Health: A Comparative Study on the Impact of Probiotics, Prebiotics, and Pomegranate (Punica granatum L.) Peel Powder [PDF]

Brazilian Journal of Poultry Science
A total of 200 one-day-old Ross 308 male broilers were randomly assigned to 4 treatments and 5 replicates in a completely randomized design to assess growth performance, serum biochemicals, and intestinal characteristics for 42 days. Treatments comprised
M Shams Shargh, O Ashayerizadeh, MH Mohammadi, SG Shirangi   +3 more
doaj   +1 more source

Sulfated Cyclocarya Paliurus Polysaccharide Sorchestrates the Gut Microbiome to Mobilize a Host‐Derived 12‐HEPE Against Ulcerative Colitis

Advanced Science, EarlyView.
A sulfated polysaccharide (SCP) from Cyclocarya paliurus alleviates ulcerative colitis by reshaping the gut microbiome. This remodeled microbiota orchestrates the upregulation of the host‐derived lipid 12‐HEPE, which directly inhibits the TLR4/NF‐κB pathway to suppress inflammation.
Xianxiang Chen, Mingyue Shen, Rui Zhang, Zhibing Huang, Hui Niu, Qiang Yu, Yi Chen, Xiangwen Pan, Liyuan Rong, Huiliang Wen, Jun Yang, Jianhua Xie   +11 more
wiley   +1 more source

A Microgel Platform Enables Site‐Specific Intestinal Delivery of Lactoferrin, Improving its Bioavailability for Targeted Alleviating Liver Injury and Colitis

Advanced Science, EarlyView.
This work first time reports an eco‐friendly desert plant food‐based polysaccharide ASKP microgels which have intestinal site‐specific release properties which can achieve small‐intestine or colon targeting capability via different cross‐linking chemistry.
Huiling Yan, Yixuan Li, Shanan Chen, Pengcheng Du, Kaiwen Wu, Hui Zhang, Kasper Hettinga, Lina Zhang, Gergely Toldi, Fazheng Ren, Yuan Li   +10 more
wiley   +1 more source

In vivo systematic analysis of microbiota-prebiotic crosstalk reveals a synbiotic that effectively ameliorates DSS-induced colitis in mice

Gut Microbes
Systematic identification of prebiotic–microbe interactions is essential for developing precision microbiome-targeted interventions to improve human health.
Qianwen Peng, Puzi Jiang, Liwen Yi, Yun Li, Qianqian Yang, Xuchun Wan, Junqing He, Zihao Mo, Haorui Niu, Qing Lan, Haidong Jia, Dezheng Xu, Chenhui Wang, Hongju Yang, Zhi Liu, Wei-Hua Chen   +15 more
doaj   +1 more source