Results 201 to 210 of about 22,026 (283)

The Multifunctional Role of Templates in Chemically Fueled Dynamic Combinatorial Libraries

ChemSystemsChem, EarlyView.
In template‐based, chemically fueled dynamic combinatorial libraries, inherently labile bonds between library members are formed at the expense of high‐energy molecules, with templates guiding the product distribution. Conversely, we demonstrate that the chemically fueled library affects the properties of the template.
Christine M. E. Kriebisch, Brigitte A. K. Kriebisch, Juliette Langlais, Anton S. Maier, Bernhard Rieger, Dieter Braun, Job Boekhoven   +6 more
wiley   +1 more source

Prebiotic synthesis of simple sugars by photoredox systems chemistry [PDF]

, 2012
Dougal J. Ritson, John D. Sutherland
openalex   +1 more source

Organic Reactivity Matters for the Emergence of Life: Kinetic Barriers and Molecular Diversity Are Suggested as Crucial Factors by Emerging Autonomous System Models

ChemSystemsChem, EarlyView.
Self‐organisation may result from organic systems fed with free energy provided that reactivity becomes a determining factor. The propensity of carbon to form covalent bonds can give rise to kinetically stable thermodynamically activated compounds possibly undergoing non‐linear kinetic processes.
Robert Pascal
wiley   +1 more source

15 Combinatorial chemistry in the prebiotic environment [PDF]

, 2013
David W. Deamer
openalex   +1 more source

Cutting‐Edge Advancements in the Antibiotics‐Gut Microbiota‐Urinary Tumour Axis

Cell Proliferation, EarlyView.
Gut microbiota regulates urological tumors. Antibiotics induce dysbiosis, altering tumor progression/therapy: reducing carcinogen metabolism but impairing immunity. Specific bacteria enhance immune responses and combat endocrine resistance. Future research should unravel microbiota‐cancer links and develop microbiome‐targeted therapies to optimize ...
Jie Wang, Dengxiong Li, Ruicheng Wu, Dechao Feng   +3 more
wiley   +1 more source

Taming Prebiotic Chemistry: The Role of Heterogeneous and Interfacial Catalysis in the Emergence of a Prebiotic Catalytic/Information Polymer System [PDF]

, 2016
Pierre‐Alain Monnard
openalex   +1 more source

Conversion of pyridoxal to pyridoxamine with NH3 and H2 on nickel generates a protometabolic nitrogen shuttle under serpentinizing conditions

The FEBS Journal, EarlyView.
Recent studies show that Ni0 catalyzes amino acid synthesis from 2‐oxoacids via reductive amination. We show that the cofactor pyridoxal is reductively aminated to pyridoxamine, the NH2‐transferring intermediate of transaminations, with NH3 (~ 5 mm) and H2 (5 bar) on Ni0 catalysts within hours in water under serpentinizing hydrothermal vent conditions (
Manon Laura Schlikker, Max Brabender, Loraine Schwander, Carolina Garcia Garcia, Maximillian Burmeister, Sabine Metzger, Joseph Moran, William F. Martin   +7 more
wiley   +1 more source

Protometabolic functions of pyridoxal: A link between early amino acid synthesis and enzyme evolution

The FEBS Journal, EarlyView.
Schlikker et al. characterized the conversion of pyridoxal to pyridoxamine under conditions mimicking the ones likely existing at the origin of metabolism. These conditions triggered nitrogen incorporation into amino acids in solution before the origins of enzymes.
Mariarita Bertoldi, Gianluca Molla
wiley   +1 more source

Infant Formula in the Digital Age: How US Online Formula Marketing Targets Parents

Maternal &Child Nutrition, EarlyView.
The online marketing materials used to display bestselling US infant formula products violate the International Code of Marketing of Breastmilk Substitutes with health claims, formula idealization, and unsafe preparation guidelines. Novel themes like ‘purity’ and ‘innovation’ highlight the need for stricter regulation of marketing practices to protect ...
Simone Froley, Cristina Watkins, Cecília Tomori   +2 more
wiley   +1 more source

A Review of the Mechanisms of Action of the Herbal Medicine, STW 5‐II, Underlying Its Efficacy in Disorders of Gut–Brain Interaction

Neurogastroenterology &Motility, EarlyView.
The pathophysiology of functional dyspepsia and irritable bowel syndrome includes altered motility, secretion, sensitivity to sensory signals, impaired epithelial barrier function, inflammation, and gut dysbiosis. The phytomedicine, STW 5‐II, represents a multi‐targeted approach, addressing these pathophysiologies.
Anita Annaházi, Rudolf Bauer, Thomas Efferth, Mohamed T. Khayyal, Michael Schemann, Gudrun Ulrich‐Merzenich, Christine Feinle‐Bisset   +6 more
wiley   +1 more source