Results 71 to 80 of about 1,043,960 (288)
Advanced Science, EarlyView.This study reveals that maternal antibiotic exposure prior to conception disrupts intergenerational gut microbial succession. By enhancing maternal‐offspring microbial transmission, altering microbial developmental trajectories and increasing selective pressures during community assembly, these disturbances lead to persistent gut mucosal immaturity and
Yuzhu Chen +8 more
wiley +1 more source
Chemical Diversity of Metal Sulfide Minerals and Its Implications for the Origin of Life
Life, 2018 Prebiotic organic synthesis catalyzed by Earth-abundant metal sulfides is a key process for understanding the evolution of biochemistry from inorganic molecules, yet the catalytic functions of sulfides have remained poorly explored in the context of the ...
Yamei Li, Norio Kitadai, Ryuhei Nakamura
doaj +1 more source
Advanced Science, EarlyView.TRF enriches Ruminococcus, a bacterial genus producing SCFAs, and activates the epithelial HIF‐1α signaling pathway. This mechanism protects the colonic mucosa from inflammatory insults in colitis models. Mechanistically, gut lactate production during starvation and refeeding mediates H4K12la, which increases SLC9A3 expression and creates an acidic gut
Linwen Huang +17 more
wiley +1 more source
The Prevailing Catalytic Role of Meteorites in Formamide Prebiotic Processes
Life, 2018 Meteorites are consensually considered to be involved in the origin of life on this Planet for several functions and at different levels: (i) as providers of impact energy during their passage through the atmosphere; (ii) as agents of geodynamics ...
Raffaele Saladino +2 more
doaj +1 more source
Life, 2021 Template-free nonenzymatic polymerization of 3′,5′ cyclic nucleotides is an emerging topic of the origin of life research. In the last ten years, a number of papers have been published addressing various aspects of this process.
Judit E. Šponer +6 more
doaj +1 more source
A thermodynamic basis for prebiotic amino acid synthesis and the nature of the first genetic code
, 2009 Of the twenty amino acids used in proteins, ten were formed in Miller's atmospheric discharge experiments. The two other major proposed sources of prebiotic amino acid synthesis include formation in hydrothermal vents and delivery to Earth via meteorites.
Chakrabarti S. +2 more
core +1 more source
Living Hydrogels: Harnessing Microorganism–Material Synergy for Next‐Generation Therapeutics
Advanced Science, EarlyView.. ABSTRACT Microorganism‐based therapies, particularly those utilizing probiotics, have emerged as a powerful biomedical strategy owing to their inherent living functionalities. These living systems can dynamically interact with host environments and self‐regulate their activity, offering superior adaptability, prolonged functionality, and ...
Shuifang Mao +3 more
wiley +1 more source
Asymmetric amplification in amino acid sublimation involving racemic compound to conglomerate conversion [PDF]
, 2011 A straightforward unprecedented sublimation protocol that reveals both conversion of a racemic compound into a racemic conglomerate and subsequent enantioenrichment has been developed for the proteinogenic amino acid valine.
Cintas, Pedro +4 more
core +4 more sources
Advanced Science, EarlyView.This study constructed the W1/O/W2 emulsion–based targeted therapy delivery system for ulcerative colitis (UC) utilizing LCC as surfactant for the first time. This multifunctional emulsion offered certain therapeutic advantages for UC, including targeted colonic delivery of active compounds, synergistic modulation of gut microbiota through combined ...
Qian Wu +9 more
wiley +1 more source
Molecular Precursors of the RNA-World in Space: New Nitriles in the G+0.693−0.027 Molecular Cloud
Frontiers in Astronomy and Space Sciences, 2022 Nitriles play a key role as molecular precursors in prebiotic experiments based on the RNA-world scenario for the origin of life. These chemical compounds could have been partially delivered to the young Earth from extraterrestrial objects, stressing the
Víctor M. Rivilla +15 more
doaj +1 more source