Results 21 to 30 of about 803,041 (283)

Decreased risk of breast cancer associated with oral bisphosphonate therapy [PDF]

, 2012
Preclinical studies and adjuvant trials using bisphosphonates have found them to have an antitumor effect. Although major advances have been made in chemoprevention strategies with selective estrogen receptor modulators and aromatase inhibitors, their ...
Brufsky, A, Mathew, A
core   +2 more sources

Quantification of white matter cellularity and damage in preclinical and early symptomatic Alzheimer\u27s disease [PDF]

, 2019
Interest in understanding the roles of white matter (WM) inflammation and damage in the pathophysiology of Alzheimer disease (AD) has been growing significantly in recent years.
Ances, Beau M, Benzinger, Tammie L.S., Blazey, Tyler, Cairns, Nigel J, Chen, Charlie, Cruchaga, Carlos, Fagan, Anne M, Gordon, Brian A, Liu, Jingxia, Morris, John C, Shimony, Joshua S, Su, Yi, Sutphen, Courtney L, Wang, Qing, Wang, Yong   +14 more
core   +2 more sources

Antitumor activity of an anti-CD98 antibody. [PDF]

, 2015
CD98 is expressed on several tissue types and specifically upregulated on fast-cycling cells undergoing clonal expansion. Various solid (e.g., nonsmall cell lung carcinoma) as well as hematological malignancies (e.g., acute myeloid leukemia) overexpress ...
Cairns, Belinda, Cantor, Joseph M, Chinn, Lawrence, Duey, Dana, Ginsberg, Mark H, H van der Horst, Edward, Hayes, Gregory M, Levashova, Zoia, Lippincott, John, Tran, Hoang, Velilla, Timothy, Zachwieja, Joseph   +11 more
core   +1 more source

TaqMan real-time PCR for detection of pathogenic Leptospira spp. in canine clinical samples

Journal of Veterinary Research, 2023
Canine leptospirosis has always been a differential diagnosis in dogs presenting with clinical signs and blood profiles associated with kidney and/or liver disease.
Rahman Mohammad Sabri Abdul, Khor Kuan Hua, Khairani-Bejo Siti, Lau Seng Fong, Mazlan Mazlina, Roslan Mohd Azri, Ajat Mohd Mokrish Md, Noor Mohd Akmal Mohd   +7 more
doaj   +1 more source

The Brain-Gut-Microbiome Axis. [PDF]

, 2018
Preclinical and clinical studies have shown bidirectional interactions within the brain-gut-microbiome axis. Gut microbes communicate to the central nervous system through at least 3 parallel and interacting channels involving nervous, endocrine, and ...
Kalani, Amir, Martin, Clair R, Mayer, Emeran A, Osadchiy, Vadim   +3 more
core   +2 more sources

Targeting Sphingolipids for Cancer Therapy

Frontiers in Oncology, 2021
Sphingolipids are an extensive class of lipids with different functions in the cell, ranging from proliferation to cell death. Sphingolipids are modified in multiple cancers and are responsible for tumor proliferation, progression, and metastasis ...
Osmel Companioni, Cristina Mir, Yoelsis Garcia-Mayea, Matilde E. LLeonart, Matilde E. LLeonart   +4 more
doaj   +1 more source

Early affective changes and increased connectivity in preclinical Alzheimer's disease. [PDF]

, 2018
IntroductionAffective changes precede cognitive decline in mild Alzheimer's disease and may relate to increased connectivity in a "salience network" attuned to emotionally significant stimuli.
Bilgel, Murat, Brown, Jesse A, Fredericks, Carolyn A, Hua, Alice Y, Resnick, Susan M, Seeley, William W, Sturm, Virginia E, Wong, Dean F   +7 more
core   +1 more source

Comparative Analysis of Nutritional Value of Oreochromis niloticus (Linnaeus), Nile Tilapia, Meat from Three Different Ecosystems

Journal of Food Quality, 2017
Determination of protein, lipid, and mineral content of fish meat is necessary to ensure that it meets requirements for food regulations and commercial specifications.
Fanuel Jim, Penina Garamumhango, Colin Musara   +2 more
doaj   +1 more source

Characterization, in-silico, and in-vitro study of a new steroid derivative from Ophiocoma dentata as a potential treatment for COVID-19

Scientific Reports, 2022
The medicinal potential of marine invertebrates' bioactive components that may act as anti-COVID-19 demonstrated promising results. Ophiocoma dentata, which is common in the Red Sea, is one such source.
Mohamed S. M. Abd El Hafez, Miral G. AbdEl-Wahab, Mohamed G. Seadawy, Mostafa F. El-Hosseny, Osama Beskales, Ali Saber Ali Abdel-Hamid, Maha A. El Demellawy, Doaa A. Ghareeb   +7 more
doaj   +1 more source

Quality and validity of large animal experiments in stroke : a systematic review [PDF]

, 2020
An important factor for successful translational stroke research is study quality. Low-quality studies are at risk of biased results and effect overestimation, as has been intensely discussed for small animal stroke research.
Bahor, Z., Boltze, Johannes, Herrmann, A. M., Kringe, L., Meckel, S., Motschall, E., Mülling, C., Sena, E. S., Wang, Q.   +8 more
core   +4 more sources