Results 21 to 30 of about 808,538 (334)

Quality and validity of large animal experiments in stroke : a systematic review [PDF]

, 2020
An important factor for successful translational stroke research is study quality. Low-quality studies are at risk of biased results and effect overestimation, as has been intensely discussed for small animal stroke research.
Bahor, Z., Boltze, Johannes, Herrmann, A. M., Kringe, L., Meckel, S., Motschall, E., Mülling, C., Sena, E. S., Wang, Q.   +8 more
core   +4 more sources

Preclinical translation of exosomes derived from mesenchymal stem/stromal cells. [PDF]

, 2020
Exosomes are nanovesicles secreted by virtually all cells. Exosomes mediate the horizontal transfer of various macromolecules previously believed to be cell-autonomous in nature, including nonsecretory proteins, various classes of RNA, metabolites, and ...
Anderson, Johnathon D, Elahi, Fanny M, Farwell, D Gregory, Nolta, Jan A   +3 more
core  

Quantification of white matter cellularity and damage in preclinical and early symptomatic Alzheimer\u27s disease [PDF]

, 2019
Interest in understanding the roles of white matter (WM) inflammation and damage in the pathophysiology of Alzheimer disease (AD) has been growing significantly in recent years.
Ances, Beau M, Benzinger, Tammie L.S., Blazey, Tyler, Cairns, Nigel J, Chen, Charlie, Cruchaga, Carlos, Fagan, Anne M, Gordon, Brian A, Liu, Jingxia, Morris, John C, Shimony, Joshua S, Su, Yi, Sutphen, Courtney L, Wang, Qing, Wang, Yong   +14 more
core   +2 more sources

TaqMan real-time PCR for detection of pathogenic Leptospira spp. in canine clinical samples

Journal of Veterinary Research, 2023
Canine leptospirosis has always been a differential diagnosis in dogs presenting with clinical signs and blood profiles associated with kidney and/or liver disease.
Rahman Mohammad Sabri Abdul, Khor Kuan Hua, Khairani-Bejo Siti, Lau Seng Fong, Mazlan Mazlina, Roslan Mohd Azri, Ajat Mohd Mokrish Md, Noor Mohd Akmal Mohd   +7 more
doaj   +1 more source

The Brain-Gut-Microbiome Axis. [PDF]

, 2018
Preclinical and clinical studies have shown bidirectional interactions within the brain-gut-microbiome axis. Gut microbes communicate to the central nervous system through at least 3 parallel and interacting channels involving nervous, endocrine, and ...
Kalani, Amir, Martin, Clair R, Mayer, Emeran A, Osadchiy, Vadim   +3 more
core   +2 more sources

Targeting Sphingolipids for Cancer Therapy

Frontiers in Oncology, 2021
Sphingolipids are an extensive class of lipids with different functions in the cell, ranging from proliferation to cell death. Sphingolipids are modified in multiple cancers and are responsible for tumor proliferation, progression, and metastasis ...
Osmel Companioni, Cristina Mir, Yoelsis Garcia-Mayea, Matilde E. LLeonart, Matilde E. LLeonart   +4 more
doaj   +1 more source

Translational perspectives on perfusion-diffusion mismatch in ischemic stroke [PDF]

, 2013
Magnetic resonance imaging has tremendous potential to illuminate ischemic stroke pathophysiology and guide rational treatment decisions. Clinical applications to date have been largely limited to trials.
Campbell, Bruce C. V., Macrae, I. Mhairi
core   +1 more source

Comparative Analysis of Nutritional Value of Oreochromis niloticus (Linnaeus), Nile Tilapia, Meat from Three Different Ecosystems

Journal of Food Quality, 2017
Determination of protein, lipid, and mineral content of fish meat is necessary to ensure that it meets requirements for food regulations and commercial specifications.
Fanuel Jim, Penina Garamumhango, Colin Musara   +2 more
doaj   +1 more source

Characterization, in-silico, and in-vitro study of a new steroid derivative from Ophiocoma dentata as a potential treatment for COVID-19

Scientific Reports, 2022
The medicinal potential of marine invertebrates' bioactive components that may act as anti-COVID-19 demonstrated promising results. Ophiocoma dentata, which is common in the Red Sea, is one such source.
Mohamed S. M. Abd El Hafez, Miral G. AbdEl-Wahab, Mohamed G. Seadawy, Mostafa F. El-Hosseny, Osama Beskales, Ali Saber Ali Abdel-Hamid, Maha A. El Demellawy, Doaa A. Ghareeb   +7 more
doaj   +1 more source

Dual role of complement in neuronal repair

Frontiers in Immunology
The complement system, long regarded as an arm of innate immunity, is now recognized as an important modulator of nervous system pathophysiology. Following acute injury or in chronic neurodegenerative diseases, promoting neuronal survival and axon ...
Agnieszka Lukomska, Peter Ciesielski, Mariusz Z. Ratajczak, Mariusz Z. Ratajczak, Magdalena Kucia   +4 more
doaj   +1 more source