Results 61 to 70 of about 45,342 (240)

Impact of inflammatory preconditioning on murine microglial proteome response induced by focal ischemic brain injury

Frontiers in Immunology
Preconditioning with lipopolysaccharide (LPS) induces neuroprotection against subsequent cerebral ischemic injury, mainly involving innate immune pathways.
Dario Lucas Helbing, Dario Lucas Helbing, Dario Lucas Helbing, Dario Lucas Helbing, Dario Lucas Helbing, Fabienne Haas, Emilio Cirri, Norman Rahnis, Therese Thuy Dung Dau, Erika Kelmer Sacramento, Nova Oraha, Nova Oraha, Leopold Böhm, Leopold Böhm, Leopold Böhm, Trim Lajqi, Pascal Fehringer, Helen Morrison, Helen Morrison, Reinhard Bauer   +19 more
doaj   +1 more source

LPS preconditioning redirects TLR signaling following stroke: TRIF-IRF3 plays a seminal role in mediating tolerance to ischemic injury

Journal of Neuroinflammation, 2011
Background Toll-like receptor 4 (TLR4) is activated in response to cerebral ischemia leading to substantial brain damage. In contrast, mild activation of TLR4 by preconditioning with low dose exposure to lipopolysaccharide (LPS) prior to cerebral ...
Lessov Nikola S, Williams-Karnesky Rebecca, Marsh Brenda J, Stevens Susan L, Vartanian Keri B, Stenzel-Poore Mary P   +5 more
doaj   +1 more source

Scalable Task Planning via Large Language Models and Structured World Representations

Advanced Robotics Research, EarlyView.
This work efficiently combines graph‐based world representations with the commonsense knowledge in Large Language Models to enhance planning techniques for the large‐scale environments that modern robots will need to face. Planning methods often struggle with computational intractability when solving task‐level problems in large‐scale environments ...
Rodrigo Pérez‐Dattari, Zhaoting Li, Robert Babuška, Jens Kober, Cosimo Della Santina   +4 more
wiley   +1 more source

Gentamicin-induced preconditioning of proximal tubular LLC-PK1 cells stimulates nitric oxide production but not the synthesis of heat shock protein

Brazilian Journal of Medical and Biological Research, 2009
Nephrotoxicity is the main side effect of antibiotics such as gentamicin. Preconditioning has been reported to protect against injuries as ischemia/reperfusion.
E.A. Pessoa, M.B. Convento, R.G. Silva, A.S. Oliveira, F.T. Borges, N. Schor   +5 more
doaj  

Grounding Large Language Models for Robot Task Planning Using Closed‐Loop State Feedback

Advanced Robotics Research, EarlyView.
BrainBody‐Large Language Model (LLM) introduces a hierarchical, feedback‐driven planning framework where two LLMs coordinate high‐level reasoning and low‐level control for robotic tasks. By grounding decisions in real‐time state feedback, it reduces hallucinations and improves task reliability.
Vineet Bhat, Ali Umut Kaypak, Prashanth Krishnamurthy, Ramesh Karri, Farshad Khorrami   +4 more
wiley   +1 more source

An Investigation of Radial Basis Function-Finite Difference (RBF-FD) Method for Numerical Solution of Elliptic Partial Differential Equations

Mathematics, 2017
The Radial Basis Function (RBF) method has been considered an important meshfree tool for numerical solutions of Partial Differential Equations (PDEs). For various situations, RBF with infinitely differentiable functions can provide accurate results and ...
Suranon Yensiri, Ruth J. Skulkhu
doaj   +1 more source

A Self‐Organized Liquid Reaction Container for Cellular Memory

Advanced Science, EarlyView.
How cells restore epigenetic information lost during replication is not known. This work proposes a mechanism based on the formation of biomolecular condensates. These condensates are induced by the chromosome itself and serve as reaction vessels for reconstructing missing epigenetic markers.
Sukanta Mukherjee, Enrico Skoruppa, Holger Merlitz, Jens‐Uwe Sommer, Helmut Schiessel   +4 more
wiley   +1 more source

Preconditioned cues have no value

eLife, 2017
Sensory preconditioning has been used to implicate midbrain dopamine in model-based learning, contradicting the view that dopamine transients reflect model-free value.
Melissa J Sharpe, Hannah M Batchelor, Geoffrey Schoenbaum   +2 more
doaj   +1 more source

Loss of SOCS1 in Donor T Cells Exacerbates Intestinal GVHD by Driving a Chemokine‐Dependent Pro‐Inflammatory Immune Microenvironment

Advanced Science, EarlyView.
T cell‐specific Socs1 knockout leads to inflammatory differentiation of CD8+ T cells, prompting the STAT1/2 complex to drive the activation of Ccl5, Ccr5, and Cxcr3, and promoting the skewing of monocytes toward a pro‐inflammatory M1 macrophage lineage.
Zhigui Wu, Bixia Wang, Xinya Jiang, Fangqing Zhang, Qianqian Huang, Xinyi Wu, Shuang Fan, Qi Zhang, Jingrui Zhou, Jianing Tang, Xiao‐Dong Mo, Yu Wang, Ying‐Jun Chang, Huidong Guo, Xiao‐Jun Huang   +14 more
wiley   +1 more source

Preconditioning of MSCs for Acute Neurological Conditions: From Cellular to Functional Impact—A Systematic Review

Cells
This systematic review aims to gather evidence on the mechanisms triggered by diverse preconditioning strategies for mesenchymal stem cells (MSCs) and their impact on their potential to treat ischemic and traumatic injuries affecting the nervous system ...
Inês Serrenho, Susana Alves Ferreira, Graça Baltazar   +2 more
doaj   +1 more source