Results 71 to 80 of about 45,342 (240)

Endogenous “Time Bomb” – Mislocalized Phospholipase A2 as a Critical Mediator of Ultra‐Rapid Mortality in Sepsis and Acute Lung Injury

Advanced Science, EarlyView.
Phospholipase A2 (PLA2), a dormant enzyme, becomes lethal when activated—collapsing lungs in minutes. Our dual therapy (DOPS + varespladib) boosts survival from 0% to >90% in sepsis/ALI. A breakthrough for acute lung injury treatment. ABSTRACT This study reveals that phospholipase A2 (PLA2), normally stable and nontoxic, can be activated specifically ...
Jianyu Wang, Zhongxing Xu, Lin Wang, Xin Sui, Yuan Luo, Xiuli Zhao, Jun Yang, Yongan Wang   +7 more
wiley   +1 more source

Improving Fat Graft Survival Using Soluble Molecule Preconditioning

Biomolecules
Fat grafting is widely used in plastic surgery to correct soft tissue deformities. A major limitation of this technique is the poor long-term volume retention of the injected fat due to tissue remodeling and adipocyte death.
Nabil Amraoui, Isabelle Xu, Jorge Robles Cortés, Chanel Beaudoin Cloutier, Julie Fradette   +4 more
doaj   +1 more source

Brain Lipopolysaccharide Preconditioning-Induced Gene Reprogramming Mediates a Tolerance State in Electroconvulsive Shock Model of Epilepsy

Frontiers in Pharmacology, 2018
There is increasing evidence pointing toward the role of inflammatory processes in epileptic seizures, and reciprocally, prolonged seizures induce more inflammation in the brain.
Elham Amini, Mojtaba Golpich, Abdoreza S. Farjam, Behnam Kamalidehghan, Zahurin Mohamed, Norlinah M. Ibrahim, Abolhassan Ahmadiani, Azman A. Raymond   +7 more
doaj   +1 more source

Spatial‐Wavelength Multiplexing Error‐Controlled Photonic Analog Computing System

Advanced Science, EarlyView.
A novel photonic integrated circuit prototype implementing the concept of general‐purpose analog computing and demonstrate its capability in radio frequency applications. The chip features a multichannel architecture and performs fully optical analog computation with frequency‐domain parallel processing. An FPGA‐based error‐correction algorithm aims to
Tao Zhu, Bowen Zhu, Shicheng Zhang, Keren Li, Xianchen Wu, Yazhi Pi, Jie Yan, Daigao Chen, Bingli Guo, Xi Xiao, Lei Wang, Xiaochuan Xu, Xuwei Xue, Shanguo Huang, Zizheng Cao, Shaohua Yu   +15 more
wiley   +1 more source

Mitochondrial preconditioning: a potential neuroprotective strategy

Frontiers in Aging Neuroscience, 2010
Mitochondria have long been known as the powerhouse of the cell. However, these organelles are also pivotal players in neuronal cell death. Mitochondrial dysfunction is a prominent feature of chronic brain disorders, including Alzheimer's and ...
Sónia C Correia, Sónia C Correia, Cristina Carvalho, Cristina Carvalho, Susana Cardoso, Susana Cardoso, Renato X Santos, Renato X Santos, Maria S Santos, Maria S Santos, Catarina Oliveira, Catarina Oliveira, George Perry, George Perry, Xiongwei Zhu, Mark A Smith, Paula I Moreira, Paula I Moreira   +17 more
doaj   +1 more source

An Implantable Scaffold Sequentially Releasing STING Agonist and B7‐H3 Antibody for Bone Metastasis Immunotherapy

Advanced Science, EarlyView.
We developed an implantable dual‐drug depot using GelMA for bone metastasis treatment, co‐delivering MSA‐2 and αB7‐H3‐loaded CaCO3 microparticles. Sustained release from GelMA scaffold enables MSA‐2 to activate STING signaling and enhance T‐cell infiltration and activation, while sequentially released αB7‐H3 blocks MSA‐2‐induced B7‐H3 upregulation ...
Qijun Lin, Hong Xiao, Shuai Fan, Kaimin Cai, Yanteng Xu, Xinwen Wang, Guanhong Chen, Chuandong Lang, Xinsheng Peng, Mingqiang Li, Yuhu Dai   +10 more
wiley   +1 more source

Pre-dive whole-body vibration better reduces decompression-induced Vascular Gas Emboli than oxygenation or a combination of both.

Frontiers in Physiology, 2016
Purpose: Since non-provocative dive profiles are no guarantor of protection against decompression sickness, novel means including pre-dive preconditioning interventions, are proposed for its prevention.
Costantino Balestra, Costantino Balestra, Sigrid Theunissen, Sigrid Theunissen, Virginie Papadopoulou, Cedric Le Mener, Peter Germonpré, Peter Germonpré, François Guerrero, François Guerrero, Pierre Lafere, Pierre Lafere, Pierre Lafere   +12 more
doaj   +1 more source

Profiling Localized Immunomodulation and Drug Biodistribution within a Subcutaneous Vascularized Niche for Cell Transplantation

Advanced Science, EarlyView.
We studied how five common immunosuppressants behave when delivered directly to a transplant site instead of systemically. Using a vascularized implant for islet transplantation, we show that local delivery protects grafts, limits drug spread to the rest of the body, and produces distinct immune signatures.
Jocelyn Nikita Campa‐Carranza, Simone Capuani, Melissa A. Willman, Alexander Rabassa, Ashley L. Joubert, Tommaso Bo, Letizia Franco, Marzia Conte, Ana L. Anaya‐García, Gabrielle E. Rome, Rim Ouni, Henry J. Seaborne, Camden A. Caffey, Dora M. Berman, Junjun Zheng, Jesus Paez‐Mayorga, Corrine Ying Xuan Chua, Shu Hsia Chen, Norma S. Kenyon, Alessandro Grattoni   +19 more
wiley   +1 more source

Role of MicroRNAs in innate neuroprotection mechanisms due to preconditioning of the brain

Frontiers in Neuroscience, 2015
Insults to the brain that are sub-threshold for damage activate endogenous protective pathways, which can temporarily protect the brain against a subsequent harmful episode.
Eva Maria Jimenez-Mateos
doaj   +1 more source

Ischaemic preconditioning [PDF]

BMJ, 1994
M, Marber, D, Walker, D, Yellon
openaire   +2 more sources