Results 11 to 20 of about 282,918 (268)
Predictive biomarkers and clinical evidence [PDF]
Basic & Clinical Pharmacology & Toxicology, 2021 AbstractPredictive biomarkers play an important role in our efforts to individualize pharmacotherapy, and within recent years, a number of different types of assays have been introduced. These biomarkers may potentially support the selection and dosage of specific drugs in order to maximize efficacy and minimize adverse reactions in the individual ...
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Predictive biomarkers in gastric cancer [PDF]
Journal of Cancer Research and Clinical Oncology, 2022 AbstractPredictive biomarkers are the mainstay of precision medicine. This review summarizes the advancements in tissue-based diagnostic biomarkers for gastric cancer, which is considered the leading cause of cancer-related deaths worldwide. A disease seen in the elderly, it is often diagnosed at an advanced stage, thereby limiting therapeutic options.
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Prognostic and Predictive Biomarkers in Gliomas [PDF]
International Journal of Molecular Sciences, 2021 Gliomas are the most common central nervous system tumors. New technologies, including genetic research and advanced statistical methods, revolutionize the therapeutic approach to the patient and reveal new points of treatment options. Moreover, the 2021 World Health Organization Classification of Tumors of the Central Nervous System has fundamentally ...
Paulina Śledzińska +4 more
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Frontiers in Oncology, 2022 Hepatocellular carcinoma (HCC) is the fifth most common malignancy and the third most common cause of cancer-related death worldwide. Due to asymptomatic patients in the early stage, most patients are diagnosed at an advanced stage and lose the ...
Penghui He +6 more
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Frontiers in Medicine, 2022 Immune checkpoint inhibitors (ICI) have been applied in treating advanced hepatocellular carcinoma (aHCC) patients, but few patients exhibit stable and lasting responses. Moreover, identifying aHCC patients suitable for ICI treatment is still challenged.
Jan-Mou Lee +16 more
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Resistance to antibody‐drug conjugates in breast cancer: mechanisms and solutions
Cancer Communications, 2023 Antibody‐drug conjugates (ADCs) are a rapidly developing therapeutic approach in cancer treatment that has shown remarkable activity in breast cancer. Currently, there are two ADCs approved for the treatment of human epidermal growth factor receptor 2 ...
Yu‐Fei Chen +3 more
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On the quantitative assessment of predictive biomarkers [PDF]
Journal of the National Cancer Institute, 2015 Predictive biomarkers are among the most direct steps towards converting precision medicine into a clinical reality. By their very definition they are fundamentally different from prognostic or diagnostic biomarkers—instead of helping identify individuals who will develop the disease, they focus on differentiating between those who will and will not ...
Jason P, Fine, Michael, Pencina
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Frontiers in Immunology, 2023 BackgroundImmunotherapy is significantly revolutionizing cancer treatment and demonstrating promising efficacy in gastric cancer (GC) patients. However, only a subset of patients could derive benefits from targeted monoclonal antibody therapy against ...
Yidan Hou +5 more
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Serum Biomarkers for the Prediction of Hepatocellular Carcinoma [PDF]
Cancers, 2021 Hepatocellular carcinoma (HCC) is a leading cause of global cancer death. Major etiologies of HCC relate to chronic viral infections as well as metabolic conditions. The survival rate of people with HCC is very low and has been attributed to late diagnosis with limited treatment options. Combining ultrasound and the biomarker alpha-fetoprotein (AFP) is
José D, Debes +6 more
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Frontiers in Immunology, 2022 BackgroundThe goal of this study was to identify potential predictive biomarkers for the therapeutic effect of infliximab (IFX) in Rheumatoid arthritis (RA) and explore the potential molecular mechanism of nonresponse to IFX treatment to achieve ...
Yongsong Cai +11 more
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