Results 31 to 40 of about 282,918 (268)

Programmed death ligand‐1 expression in gastrointestinal cancer: Clinical significance and future challenges

Annals of Gastroenterological Surgery, 2020
Cancer immunotherapy has caused a paradigm shift from conventional therapies that directly target cancer cells to innovative therapies that utilize the host immune system.
Kohei Yamashita, Masaaki Iwatsuki, Jaffer A. Ajani, Hideo Baba   +3 more
doaj   +1 more source

Image-Based Network Analysis of DNp73 Expression by Immunohistochemistry in Rectal Cancer Patients

Frontiers in Physiology, 2020
Background: Rectal cancer is a disease characterized with tumor heterogeneity. The combination of surgery, radiotherapy, and chemotherapy can reduce the risk of local recurrence.
Tuan D. Pham, Tuan D. Pham, Chuanwen Fan, Chuanwen Fan, Daniella Pfeifer, Hong Zhang, Xiao-Feng Sun   +6 more
doaj   +1 more source

A flexible approach for predictive biomarker discovery

Biostatistics, 2022
Summary An endeavor central to precision medicine is predictive biomarker discovery; they define patient subpopulations which stand to benefit most, or least, from a given treatment. The identification of these biomarkers is often the byproduct of the related but fundamentally different task of treatment rule estimation.
Philippe Boileau, Nina Ting Qi, Mark J van der Laan, Sandrine Dudoit, Ning Leng   +4 more
openaire   +3 more sources

MarkerPredict: predicting clinically relevant predictive biomarkers with machine learning

npj Systems Biology and Applications
Precision oncology relies on predictive biomarkers for selecting targeted cancer therapies. Network-based properties of proteins, together with structural features such as intrinsic disorder, are likely to shape their potential as biomarkers.
Daniel V. Veres, Peter Csermely, Klára Schulc   +2 more
doaj   +1 more source

The presence of senescent peripheral T-cells is negatively correlated to COVID-19 vaccine-induced immunity in cancer patients under 70 years of age

Frontiers in Immunology, 2023
PurposeCancer patients are at risk of severe COVID-19 infection, and vaccination is recommended. Nevertheless, we observe a failure of COVID-19 vaccines in this vulnerable population.
E. Orillard, E. Orillard, L. Spehner, L. Spehner, L. Mansi, L. Mansi, A. Bouard, A. Falcoz, A. Falcoz, Q. Lepiller, Q. Lepiller, E. Renaude, JR. Pallandre, JR. Pallandre, A. Vienot, A. Vienot, M. Kroemer, M. Kroemer, M. Kroemer, C. Borg, C. Borg, C. Borg   +21 more
doaj   +1 more source

Heterogeneity in the Global Practice of Central Nervous System Staging in Pediatric Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) involvement in childhood acute lymphoblastic leukemia (ALL) is assessed by cell counting and cytomorphology from cerebrospinal fluid (CSF) and is used for treatment stratification worldwide. The ratio of “CNS2” patients in clinical trials ranges from 3% to 40%, with unclear prognostic significance ...
Laura Almási, Bernadett Borbála Huszti, Gábor Barna, Marko Kavcic, Janez Jazbec, Lennart Lenk, Vera Münch, Sophia Polychronopoulou, Ágnes Márk, Maria Thastrup, Lüder H. Meyer, Kjeld Schmiegelow, Cornelia Eckert, Christina Halsey, Dániel J. Erdélyi   +14 more
wiley   +1 more source

Protein biomarker signatures of preeclampsia - a longitudinal 5000-multiplex proteomics study

Scientific Reports
We aimed to explore novel biomarker candidates and biomarker signatures of late-onset preeclampsia (LOPE) by profiling samples collected in a longitudinal discovery cohort with a high-throughput proteomics platform. Using the Somalogic 5000-plex platform,
Maren-Helene Langeland Degnes, Ane Cecilie Westerberg, Ina Jungersen Andresen, Tore Henriksen, Marie Cecilie Paasche Roland, Manuela Zucknick, Trond Melbye Michelsen   +6 more
doaj   +1 more source

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta, Jeremy D. Rubinstein, Christopher E. Dandoy, Ruby Khoury, Angela Faulhaber, Christine L. Phillips, Christa Krupski   +6 more
wiley   +1 more source

Therapeutic Apheresis for Intravenous Methylprednisolone‐Refractory Neuromyelitis Optica Spectrum Disorder: Clinical and Radiological Outcomes in a Single‐Center Case Series

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing autoimmune disease of the central nervous system. High‐dose intravenous methylprednisolone (IVMP) is the standard first‐line therapy for acute attacks, although some patients remain refractory.
Wataru Horiguchi, Daisuke Katagiri, Takeyuki Watadani, Shunichi Matsuda, Hiroshi Kaneko, Noritoshi Arai   +5 more
wiley   +1 more source

Evaluation of B cell related markers and autoantibodies in rheumatoid arthritis patients treated with abatacept

Frontiers in Immunology
ObjectivesTo investigate whether biomarkers related to B cell activation and autoantibody production are associated with the response to abatacept in rheumatoid arthritis (RA) patients.MethodsTwenty-five patients with RA were enrolled in this study ...
Ting Wang, Natalia V. Giltiay, Christian Lood, Ning Wang, Bobby Kwanghoon Han   +4 more
doaj   +1 more source