Results 111 to 120 of about 1,054,636 (275)

An Active Inference Agent for Modeling Human Translation Processes

open access: yesEntropy
This paper develops an outline for a hierarchically embedded architecture of an artificial agent that models human translation processes based on principles of active inference (AIF) and predictive processing (PP).
Michael Carl
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Predicting Integrals of Stochastic Processes

open access: yesThe Annals of Applied Probability, 1995
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +2 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

A Comparative Neurophenomenology of the Psychedelic State and Autism: Predictive Processing as a Unifying Lens

open access: yesPsychoactives
Serotonergic psychedelics, particularly psilocybin, lysergic acid diethylamide (LSD), and dimethyltryptamine (DMT), are increasingly recognised as powerful tools to advance the understanding of consciousness and its relation to brain activity ...
William Roseby, Catriona Osborn Moar
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Reading by proxy: A visit to the literary archive

open access: yesCogent Arts & Humanities, 2019
If literature is an archive of cognitive constellations, then readers can revisit these experiences from different periods and ages. How familiar, however, does a reader have to be with a particular historical context in order to browse the literary ...
Karin Kukkonen
doaj   +1 more source

Both symbolic and embodied representations contribute to spatial language processing: Evidence from younger and older adults [PDF]

open access: yes, 2015
Building on earlier neuropsychological work, we adopted a novel individual differences approach to examine the relationship between spatial language and a wide range of both verbal and nonverbal abilities.
Coventry, Kenny   +3 more
core  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

The Predictive Processing Model of EMDR

open access: yesFrontiers in Psychology, 2019
Eye Movement Desensitization and Reprocessing Therapy (EMDR) is an effective treatment for Post-traumatic Stress Disorder (PTSD). The Adaptive Information Processing Model (AIP) guides the development and practice of EMDR. The AIP postulates inadequately
D. Eric Chamberlin
doaj   +1 more source

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