Results 101 to 110 of about 883,483 (401)

Multi‐Region Brain Organoids Integrating Cerebral, Mid‐Hindbrain, and Endothelial Systems

Advanced Science, EarlyView.
Multi‐Region Brain Organoids combine cerebral, mid/hindbrain, and endothelial components into an advanced 3D model capturing 80% of fetal brain cellular diversity. This platform reveals essential endothelial‐neural signaling networks that maintain region‐specific intermediate progenitors during hindbrain development.
Anannya Kshirsagar, Hayk Mnatsakanyan, Sai Kulkarni, John Guo, Kai Cheng, Luke Daniel Ofria, Oce Bohra, Ram Sagar, Vasiliki Mahairaki, Christian E Badr, Annie Kathuria   +10 more
wiley   +1 more source

Dichotomous organization of amygdala/temporal-prefrontal bundles in both humans and monkeys

eLife, 2019
The interactions of anterior temporal structures, and especially the amygdala, with the prefrontal cortex are pivotal to learning, decision-making, and socio-emotional regulation.
Davide Folloni, Jerome Sallet, Alexandre A Khrapitchev, Nicola Sibson, Lennart Verhagen, Rogier B Mars   +5 more
doaj   +1 more source

Aberrant Mitochondrial Metabolism in Alzheimer's Disease Links Energy Stress with Ferroptosis

Advanced Science, EarlyView.
Alves et al. reveal how energy loss and oxidative stress, two major features of Alzheimer's disease, are connected. Mitochondria controls the flux of the antioxidant glutathione (GSH), via facilitating both its production and consumption. Energy restriction limits GSH synthesis, conferring vulnerability to cell death by ferroptosis, implicated as a ...
Francesca Alves, Darius Lane, Adam Wahida, Md. Jakaria, Pawel Kalinowski, Adam Southon, Abdel Ali Belaidi, Teresa Samperi‐Esteve, Triet Phu Minh Nguyen, Peng Lei, Marcus Krueger, Stefan Mueller, Marcus Conrad, Puja Agarwal, Sue E Leurgans, Julie Schneider, Ashley I. Bush, Scott Ayton   +17 more
wiley   +1 more source

N-acetyl-aspartate level is decreased in the prefrontal cortex in subjects at-risk for schizophrenia.

Frontiers in Psychiatry, 2013
Reduced N-Acetyl-Aspartate (NAA) levels have been reported in the prefrontal cortex in patients with schizophrenia using proton magnetic resonance spectroscopy.
Marine eMondino, Jerome eBrunelin, Mohamed eSAOUD   +2 more
doaj   +1 more source

Prefrontal cortex output circuits guide reward seeking through divergent cue encoding

Nature, 2017
The prefrontal cortex is a critical neuroanatomical hub for controlling motivated behaviours across mammalian species. In addition to intra-cortical connectivity, prefrontal projection neurons innervate subcortical structures that contribute to reward ...
James M. Otis, V. M. Namboodiri, Ana M. Matan, E. Voets, Emily P. Mohorn, O. Kosyk, J. McHenry, J. E. Robinson, Shanna Resendez, Mark A. Rossi, G. Stuber   +10 more
semanticscholar   +1 more source

The role of the lateral prefrontal cortex and anterior cingulate in stimulus–response association reversals [PDF]

, 2007
Many complex tasks require us to flexibly switch between behavioral rules, associations, and strategies. The prefrontal cerebral cortex is thought to be critical to the performance of such behaviors, although the relative contribution of different ...
Abdelmalek Benattayallah, Benjamin A. Parris, Duncan J., Goldman-Rakic P. S., Ian R. Summers, Ngoc J. Thai, Timothy L. Hodgson   +6 more
core   +1 more source

A Novel Cranial Bone Transport Technique Repairs Skull Defect and Minimizes Brain Injury Outcome in Traumatic Brain Injury Rats

Advanced Science, EarlyView.
This study introduces a novel, safe, and effective surgical technique: Cranial bone transport (CBT) to improve traumatic brain injury (TBI) outcomes in rats. CBT significantly accelerated skull defect bone repair in addition to its promoting effects on neurological function recovery. This work provides an alternative therapy for patients suffering from
Shanshan Bai, Xuan Lu, Xu Yan, Han Su, Yuejun Lin, Zhaowei Jiang, Zhixian Zong, Haixing Wang, Leo Yik Chun Yan, Xiaoting Zhang, Ming Wang, Zhengmeng Yang, Jiakang Jin, Yaofeng Wang, Wayne Yuk‐Wai Lee, Xiaohua Jiang, Ho Ko, Lu Feng, Micky D. Tortorella, Sien Lin, Gang Li   +20 more
wiley   +1 more source

Choline in Pediatric Depression

McGill Journal of Medicine, 2020
Purpose of Study: The prefrontal cortex has been previously implicated in the neuropathology of major depressive disorder (MDD). Hence, we used proton magnetic resonance spectroscopy (1H-MRS) to examine choline levels in the prefrontal cortex of youth ...
Frank P MacMaster, Vivek Kusumakar
doaj   +1 more source

Prefrontal response and frontostriatal functional connectivity to monetary reward in abstinent alcohol-dependent young adults. [PDF]

PLoS ONE, 2014
Although altered function in neural reward circuitry is widely proposed in models of addiction, more recent conceptual views have emphasized the role of disrupted response in prefrontal regions. Changes in regions such as the orbitofrontal cortex, medial
Erika E Forbes, Eric E Rodriguez, Samuel Musselman, Rajesh Narendran   +3 more
doaj   +1 more source

Intestinal Clock Promotes Cognitive Memory Through Adenosine Signaling

Advanced Science, EarlyView.
The intestinal clock controls the expression of an adenosine enzyme that modulates systemic adenosine level and A1R signaling in the hippocampus, and in turn, cognitive function involving long‐term potentiation and BDNF‐dependent synaptic changes.
Min Chen, Fugui Zhang, Yifei Xiao, Xuejun Jiang, Zhiqian Yan, Jinyi Wang, Xiting Lv, Jialu Cui, Linna Ha, Hui Chen, Yongkang Dang, Zifei Qin, Jing Yang, Baojian Wu   +13 more
wiley   +1 more source