Results 51 to 60 of about 199,923 (254)
PLoS ONE, 2019 Allergic rhinitis is a chronic inflammatory disease of the upper respiratory tract, which is associated with high incidence of anxiety symptom. There is evidence that medial prefrontal cortex modulates anxiety-related behaviors and receives projections ...
Morteza Salimi +8 more
doaj +1 more source
Frontiers in Human Neuroscience, 2021 Resource scarcity imposes challenging demands on the human cognitive system. Insufficient resources cause the scarcity mindset to affect cognitive performance, while reward enhances cognitive function.
Xiaowei Jiang +7 more
doaj +1 more source
Advanced Science, EarlyView.A large‐scale multiomic dataset (proteomic and metabolomic) comprising 3,060 plasma samples were analyzed to identify proteins, metabolites, pathways, and protein‐associated drugs linked to Alzheimer’s Disease (AD) independently of apolipoprotein E (APOE). AD was associated with a distinct molecular signature that captures.
Fuhai Li +22 more
wiley +1 more source
Aberrant Splicing Signatures Underpin Oligodendrocyte Damage in ALS and Neuron Loss in FTD
Advanced Science, EarlyView.Integrating bulk and single‐nucleus RNA‐seq from ALS and FTD patients, we revealed distinct cellular dysfunctions, with severe oligodendrocyte damage in ALS and pronounced neuron loss in FTD. We identified cell‐type‐specific aberrant splicing events as potential biomarkers with robust classification performance, some of which produce de novo peptides ...
Chen Du +6 more
wiley +1 more source
Increased firing irregularity as an emergent property of neural-state transition in monkey prefrontal cortex. [PDF]
PLoS ONE, 2013 Flexible behaviors are organized by complex neural networks in the prefrontal cortex. Recent studies have suggested that such networks exhibit multiple dynamical states, and can switch rapidly from one state to another.
Kazuhiro Sakamoto +5 more
doaj +1 more source
Neuid: A Novel Neuron‐Enriched LncRNA that Connects Epigenetic Gene Silencing to Alzheimer's Disease
Advanced Science, EarlyView.ABSTRACT The increasing evidence that non‐coding RNAs can become deregulated during pathogenesis is dramatically expanding the space for drug discovery beyond the protein‐coding genome. Long noncoding RNAs (lncRNAs) are emerging as key regulators of cellular function, yet most remain uncharacterized.
Ranjit Pradhan +17 more
wiley +1 more source
Brain, 1999 By Joaquin M. Fuster. 1997. Pp. 352. Philadelphia: Lippincott-Raven.Price £60. ISBN 0-397-51849-8. In the first edition of The Prefrontal Cortex the author set out his hypothesis concerning the functions of the prefrontal association cortex. These are conceived as being not modality specific but as integrative in nature, orchestrating the \`sensory ...
openaire +3 more sources
The Lateral Prefrontal Cortex and Selection/Inhibition in ADHD
Frontiers in Human Neuroscience, 2018 A previous paper from our lab (Shalom, 2009) presented evidence that the medial part of the prefrontal cortex is involved in the integration of raw, unintegrated information into coherent, wholistic mental representations such as perceptual objects ...
Ziv Ronel
doaj +1 more source
S3RL: Enhancing Spatial Single‐Cell Transcriptomics With Separable Representation Learning
Advanced Science, EarlyView.Separable Spatial Representation Learning (S3RL) is introduced to enhance the reconstruction of spatial transcriptomic landscapes by disentangling spatial structure and gene expression semantics. By integrating multimodal inputs with graph‐based representation learning and hyperspherical prototype modeling, S3RL enables high‐fidelity spatial domain ...
Laiyi Fu +6 more
wiley +1 more source
Brain and BehaviorEmerging evidences suggest that cognitive deficits in individuals with mild cognitive impairment (MCI) are associated with disruptions in brain functional connectivity (FC).
Shuangyan Wang +3 more
doaj +1 more source