Results 21 to 30 of about 586 (172)

Biosynthesis of 3β‐hydroxy‐5,7‐pregnadien‐20‐one by the horse fetal gonad

FEBS Letters, 1983
The production of equilin and the other ring B‐unsaturated estrogens by the pregnant mare is anomalous in that they are biosynthesised by a cholesterol‐independent pathway. Fetal horse gonads were incubated with tritiated sodium acetate and radiochemically pure 3β‐hydroxy‐5,7‐pregnadien‐20‐one and 3β‐hydroxy‐5,7‐androstadien‐17‐one were isolated.
L.C. Hodge, W.R. Allen, A.D. Tait
openaire   +3 more sources

Lipid‐Regulating Effect of Traditional Chinese Medicine: Mechanisms of Actions

Evidence-Based Complementary and Alternative Medicine, Volume 2012, Issue 1, 2012., 2012
Traditional Chinese medicine (TCM) has been increasingly used for the treatment of dyslipidemia and cardiovascular disease. Recently, much progress has been made in studies on the mechanisms of action of the lipid‐regulating effect of TCM in animal experiments.
Wei-Jian Bei, Jiao Guo, Hai-Yun Wu, Yang Cao, Keji Chen   +4 more
wiley   +1 more source

Production of Prednisolone by Pseudomonas oleovorans Cells Incorporated Into PVP/PEO Radiation Crosslinked Hydrogels

BioMed Research International, Volume 2004, Issue 4, Page 219-226, 2004., 2004
In order to rise the yield of prednisolone from hydrocortisone, the Pseudomonas oleovorans cells were entrapped into radiation crosslinked poly (vinyl pyrrolidone)/poly(ethylene oxide) (PVP/PEO) hydrogel of different gel contents. The factors affecting the gel content and swelling behavior of the polymeric gel, such as polymer composition, polymer ...
Abeer Abd El-Hady, Hassan A. Abd El-Rehim   +1 more
wiley   +1 more source

Identification of the aldolase responsible for the production of 22‐hydroxy‐23,24‐bisnorchol‐4‐ene‐3‐one from natural sterols in Mycolicibacterium smegmatis

Microbial Biotechnology, Volume 17, Issue 1, January 2024.
We have identified the MSMEG_6561 gene, encoding an aldolase responsible for the transformation of 22‐hydroxy‐3‐oxo‐cholest‐4‐ene‐24‐carboxyl‐CoA (22‐OH‐BCN‐CoA) into the 22‐hydroxy‐23,24‐bisnorchol‐4‐ene‐3‐one (4‐HBC) precursor (20S)‐3‐oxopregn‐4‐ene‐20‐carboxaldehyde (3‐OPA).
Gabriel Hernández‐Fernández, Miguel G. Acedos, José L. García, Beatriz Galán   +3 more
wiley   +1 more source

A Distinct MaoC-like Enoyl-CoA Hydratase Architecture Mediates Cholesterol Catabolism in Mycobacterium tuberculosis

ACS Chemical Biology, 2014
The Mycobacterium tuberculosis (Mtb) igr operon plays an essential role in Mtb cholesterol metabolism, which is critical for pathogenesis during the latent stage of Mtb infection.
Meng Yang, K. Guja, Suzanne T Thomas, Miguel Garcia-Diaz, N. Sampson   +4 more
semanticscholar   +1 more source

Guggulsterone (GS) inhibits smokeless tobacco and nicotine-induced NF-κB and STAT3 pathways in head and neck cancer cells.

Carcinogenesis, 2011
Understanding the molecular pathways perturbed in smokeless tobacco- (ST) associated head and neck squamous cell carcinoma (HNSCC) is critical for identifying novel complementary agents for effective disease management.
M. Macha, A. Matta, S. Chauhan, K. M. Siu, R. Ralhan   +4 more
semanticscholar   +1 more source

Mycobacterium tuberculosis exploits a heterohexameric enoyl-CoA hydratase retro-aldolase complex for cholesterol catabolism.

Biochemistry, 2019
Cholesterol catabolism plays an important role in Mycobacterium tuberculosis's (Mtb's) survival and persistence in the host. Mtb exploits three β-oxidation cycles to fully degrade the side-chain of cholesterol.
Tianao Yuan, Meng Yang, K. Gehring, N. Sampson   +3 more
semanticscholar   +1 more source

Crystal Stucture of 17α-Acetoxy-6-chloro-16β-methyl-4,6-pregnadiene-3,20-dione

Analytical Sciences, 1998
M. Soriano-Garcı́a, Simón Hernández‐Ortega, Eugene Bratoeff, Gregoria Flores, Elena Ramı́rez   +4 more
openalex   +4 more sources

Guggulsterone induces heme oxygenase-1 expression through activation of Nrf2 in human mammary epithelial cells: PTEN as a putative target.

Carcinogenesis, 2012
Guggulsterone (GS) [4,17(20)-pregnadiene-3,16-dione] is a phytosterol found in the gum resin of the Commiphora mukul. GS exists naturally in two stereoisomers: E-GS (cis-GS) and Z-GS (trans-GS). In this study, the effects of both isomers on expression of
Inas Almazari, Jong‐Min Park, Sin-Aye Park, Jinyoung Suh, H. Na, Y. Cha, Y. Surh   +6 more
semanticscholar   +1 more source

Progesterone receptor characterized by photoaffinity labelling in the plasma membrane of Xenopus laevis oocytes.

Biochemical Journal, 1984
R 5020 (17,21-dimethyl-19-nor-4,9-pregnadiene-3,20-dione) is a synthetic analogue of progesterone, which is the physiological hormone that reinitiates germinal vesicle breakdown in Xenopus laevis oocytes.
Jean-Paul Blondeau andEtienne-Emile Baulieu
semanticscholar   +1 more source