Results 131 to 140 of about 10,479 (197)

Sustained Drug-Drug Interaction Between Cyclosporine and Apalutamide in a Patient With Metastatic Hormone-Sensitive Prostate Cancer: A Case Report and Evaluation of CYP3A4 Induction via Pregnane X Receptor Activation by Apalutamide. [PDF]

Case Rep Oncol Med
Mimura Y, Sanda T, Unno R, Furukawa Y, Shizu R, Motokatsu K, Tashiro Y, Tasaki Y, Sugiyama Y, Yasujima T, Naiki T, Horita Y, Hotta Y, Yuasa H, Yoshinari K, Yasui T, Iida S, Furukawa-Hibi Y.   +17 more
europepmc   +1 more source

Pregnane X receptor agonist nomilin extends lifespan and healthspan in preclinical models through detoxification functions. [PDF]

Nat Commun, 2023
Fan S, Yan Y, Xia Y, Zhou Z, Luo L, Zhu M, Han Y, Yao D, Zhang L, Fang M, Peng L, Yu J, Liu Y, Gao X, Guan H, Li H, Wang C, Wu X, Zhu H, Cao Y, Huang C.   +20 more
europepmc   +1 more source

Pregnane X receptor expression in human pancreatic adenocarcinoma: Associations with clinicopathologic parameters, tumor proliferative capacity, patients' survival, and retinoid x receptor expression

, 2015
Objectives: Pregnane X receptor (PXR) has been involved in human malignancy, either by directly affecting carcinogenesis or by inducing drugdrug interactions and chemotherapy resistance.
Kouraklis, G., Zizi-Serbetzoglou, A., Patsouris, E., Alexandrou, P., Koutsounas, I., Giaginis, C., Theocharis, S.   +6 more
core  

Targeting pregnane X receptor with a potent agonist-based PROTAC to delay colon cancer relapse. [PDF]

Oncogenesis
Bansard L, Laconde G, Delfosse V, Huet T, Ayeul M, Rigal E, Donati Q, Gerbal-Chaloin S, Daujat-Chavanieu M, Brunel L, Legrand B, Chavanieu A, Martin AR, Pannequin J, Bourguet W, Amblard M, Pascussi JM.   +16 more
europepmc   +1 more source

Expression and Prognostic Implication of the Nuclear Receptors Farnesoid X Receptor and Pregnane X Receptor in Human Cholangiocarcinoma. [PDF]

Cancer Diagn Progn
Sa-Ngiamwibool P, Yoshinari K, Shizu R, Kongpetch S, Prawan A, Senggunprai L.   +5 more
europepmc   +1 more source

Hepatic ZBTB22-mediated detoxification ameliorates acetaminophen-induced liver injury by inhibiting pregnane X receptor signaling. [PDF]

iScience, 2023
Chen Y, Cui T, Xiao S, Li T, Zhong Y, Tang K, Guo J, Huang S, Chen J, Li J, Wang Q, Huang J, Pan H, Gao Y.   +13 more
europepmc   +1 more source

Pregnane X receptor protects against age-related bone loss in males via PI3K/Akt-mediated inhibition of apoptosis. [PDF]

Cell Death Discov
Li S, Xu Y, Xu W, Zhang D, Lin X, Hu P, Si H.   +6 more
europepmc   +1 more source

Blockade of the estrogen receptor alpha-pregnane X receptor axis protects ovariectomized mice against ethanol-induced hepatotoxicity. [PDF]

J Biol Chem
Twum E, Ofosu-Boateng M, Nnamani DO, Gebreyesus LH, Yadak N, Kharbanda KK, Gonzalez FJ, Gyamfi MA.   +7 more
europepmc   +1 more source

Pregnane X receptor activation alleviates renal fibrosis in mice via interacting with p53 and inhibiting the Wnt7a/β-catenin signaling. [PDF]

Acta Pharmacol Sin, 2023
Ming WH, Luan ZL, Yao Y, Liu HC, Hu SY, Du CX, Zhang C, Zhao YH, Huang YZ, Sun XW, Qiao RF, Xu H, Guan YF, Zhang XY.   +13 more
europepmc   +1 more source

Pregnane X receptor (PXR) as a prognostic marker and therapeutic target in kidney renal clear cell carcinoma (KIRC) via AMPK pathway regulation. [PDF]

Sci Rep
Hu WJ, Liu M, Bao YN, Su BW, Sui X, Cui XH, Wang GY, Wen L, Wen RK, Wang WH, Yang HX, Luan ZL.   +11 more
europepmc   +1 more source