Results 131 to 140 of about 8,905 (163)

Pregnane X Receptor Activation in Liver Perfusion

Transplantation Proceedings, 2022
Liver normothermic machine perfusion (NMP) is being adopted as a method of optimizing livers before transplantation. However, there is further potential to use the NMP model as a platform for drug delivery. Pregnane X receptor (PXR) activation upregulates CYP3A expression and has been shown to be protective against ischemia-reperfusion in rodents.
Samuel Moulding, Rodrigo Figueiredo, Avinash Sewpaul, Alistair Leitch, Lucy Bates, Matthew Wright, Colin Wilson   +6 more
openaire   +3 more sources

Transcriptional Regulation of the Human Pregnane-X Receptor

Drug Metabolism Reviews, 2006
This review addresses the general structure and function of nuclear receptors and places specific emphasis on their role in xenosensing, resulting in the activation of a battery of genes mediating drug metabolism, conjugation, and transport. The pregnane-X receptor is a nuclear receptor that functions to control a battery of genes predominantly ...
Gibson, GG, Phillips, A, Aouabdi, S, Plant, K, Plant, N   +4 more
openaire   +4 more sources

Dietary phytochemicals as modulators of human pregnane X receptor

Critical Reviews in Food Science and Nutrition, 2021
As a promiscuous xenobiotic sensor, pregnane X receptor (PXR) plays a crucial role in drug metabolism. Since dietary phytochemicals exhibit the potential to modulate human PXR, this review aims to summarize the plant-derived PXR modulators, including agonists, partial agonists, and antagonists.
Jie, Zhang, Petr, Pavek, Rajamanikkam, Kamaraj, Li, Ren, Tiehua, Zhang   +4 more
openaire   +2 more sources

Pregnane X Receptor‐Mediated Transcription

2005
The pregnane X receptor (PXR, receptor NR1I2) is a ligand-activated transcription factor that is activated by structurally diverse endogenous steroids and foreign chemicals and serves as an important steroid and xenobiotic sensor. This member of the nuclear receptor superfamily is highly expressed in liver and in the gastrointestinal tract, where it ...
Thomas K H, Chang, David J, Waxman
openaire   +2 more sources

A Pharmacophore for Human Pregnane X Receptor Ligands

Drug Metabolism and Disposition, 2002
The pregnane X receptor (PXR) is involved in transcriptional regulation of multiple cytochromes P450 and multidrug resistance-associated protein (MDR1), which encodes for the drug transporter P-glycoprotein. Crystal structure analyses suggest that the ligand binding domain is highly hydrophobic and flexible, allowing molecules of differing sizes to ...
Sean, Ekins, Jon A, Erickson
openaire   +2 more sources

Functions of pregnane X receptor in self-detoxification

Amino Acids, 2017
Pregnane X receptor (PXR, NR1I2), a member of the nuclear receptor superfamily, is a crucial regulator of nutrient metabolism and metabolic detoxification such as metabolic syndrome, xenobiotic metabolism, inflammatory responses, glucose, cholesterol and lipid metabolism, and endocrine homeostasis.
Liuqin, He, Xihong, Zhou, Niu, Huang, Huan, Li, Tiejun, Li, Kang, Yao, Yanan, Tian, Chien-An Andy, Hu, Yulong, Yin   +8 more
openaire   +2 more sources

Rabbit Pregnane X Receptor Is Activated by Rifampicin

Drug Metabolism and Disposition, 2000
Reverse transcriptase-polymerase chain reaction was used to amplify a partial cDNA from rabbit lung mRNA that shared 77% protein sequence identity with the mouse pregnane X receptor (PXR). Rapid amplification of cDNA ends from a rabbit kidney lambdaZAP expression library resulted in the isolation of overlapping cDNAs spanning the complete coding ...
U, Savas, M R, Wester, K J, Griffin, E F, Johnson   +3 more
openaire   +2 more sources

[Advances on pregnane X receptor].

Sheng li ke xue jin zhan [Progress in physiology], 2012
Pregnane X receptor (PXR), termed with its cognate ligand, is a member of the nuclear receptor superfamily. PXR is expressed mainly in liver, intestine, stomach and kidney, and plays a central role in protecting tissues from potentially toxic exogenous and endogenous compounds.
Jian-ming, Zhou, Yu-guang, Wang, Zhi-wu, Chen   +2 more
openaire   +3 more sources

ROLE OF THE NUCLEAR RECEPTOR PREGNANE X RECEPTOR IN ACETAMINOPHEN HEPATOTOXICITY

Drug Metabolism and Disposition, 2005
The pregnane X receptor (PXR) is a transcriptional regulator of xenobiotic metabolizing enzymes, including cytochrome P450 3A (CYP3A), and transporters. Pretreatment of mice and rats with inducers of CYP3A increases acetaminophen (APAP) hepatotoxicity. In untreated mice, the amount of hepatic CYP3A11 mRNA is 4-fold greater in PXR(-/-) mice compared to ...
Kristina K, Wolf, Sheryl G, Wood, Jane A, Hunt, Brooke W, Walton-Strong, Kazuto, Yasuda, Lubin, Lan, Su X, Duan, Qin, Hao, Steven A, Wrighton, Elizabeth H, Jeffery, Ronald M, Evans, Juliana G, Szakacs, Lisa L, von Moltke, David J, Greenblatt, Michael H, Court, Erin G, Schuetz, Peter R, Sinclair, Jacqueline F, Sinclair   +17 more
openaire   +2 more sources

Pregnane X Receptor: Promiscuous regulator of detoxification pathways

The International Journal of Biochemistry & Cell Biology, 2007
The Pregnane X Receptor (PXR) is pivotal for the body's response to toxic xenobiotics and endogenous metabolites. By acting as a ligand-activated transcription factor, PXR regulates all stages of xenobiotic metabolism and transport and is responsible for important inductive drug interactions.
Marko, Matic, Andre, Mahns, Maria, Tsoli, Anthony, Corradin, Patsie, Polly, Graham R, Robertson   +5 more
openaire   +2 more sources