Pregnane X Receptor Activators Inhibit Human Hepatic Stellate Cell Transdifferentiation In Vitro
BACKGROUND & AIMS: The activated pregnane X receptor is antifibrogenic in rodent chronic liver injury in vivo models. The aim of this study was to determine the effects of human pregnane X receptor activators on human hepatic stellate cell ...
Tucker SJ +11 more
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Synthetic drugs and natural products as modulators of constitutive androstane receptor (CAR) and pregnane X receptor (PXR). Drug Metab [PDF]
, 2006 Constitutive androstane receptor (CAR) and pregnane X receptor (PXR) are members of the nuclear receptor superfamily. These transcription factors are predominantly expressed in the liver, where they are activated by structurally diverse compounds ...
Thomas K H Chang, David J Waxman
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, 2013 Chicory (Cichorium intybus) has been shown to induce enzymes of pharmacokinetic relevance (cytochrome P450; CYP). The aim of this study was to investigate the effects of selected secondary plant metabolites with a global extract of chicory root, on the ...
Ekstrand, Bo +2 more
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Sustained Isoprostane E2 Elevation, Inflammation and Fibrosis after Acute Ischaemia-Reperfusion Injury Are Reduced by Pregnane X Receptor Activation [PDF]
Liver grafts donated after cardiac death are increasingly used to expand the donor pool but are prone to ischaemic-type biliary lesions. The anti-inflammatory effects of the activated pregnane X receptor have previously been shown to be beneficial in a ...
Vallance AE +10 more
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, 2015 Xianxie Zhang,1 Yuguang Wang,2 Zengchun Ma,2 Qiande Liang,2 Xianglin Tang,2 Donghua Hu,2 Hongling Tan,2 Chengrong Xiao,2 Yue Gao2 1Air Force General Hospital of People’s Liberation Army, Beijing, People’s Republic of China; 2Department of ...
Hu D +8 more
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Pregnane X Receptor and Increase Warfarin Clearance in Rats
, 2005 The traditional Chinese medicines (TCMs) are essential components of alternative medicines. Many TCMs are known to alter the expression of hepatic drug-metabolizing enzymes and transporters. The molecular mechanism by which TCMs and/or their constituents
Wen Xie +10 more
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Advances in drug resistance of triple negative breast cancer caused by pregnane X receptor. [PDF]
World J Clin Oncol, 2023 Rao ZZ, Tang ZW, Wen J.
europepmc +1 more source
Protocatechuic acid inhibits LPS-induced mastitis in mice through activating the pregnane X receptor. [PDF]
J Cell Mol Med, 2023 Zhao L, Jin L, Yang B.
europepmc +1 more source
Screening Method for the Identification of Compounds That Activate Pregnane X Receptor. [PDF]
Curr Protoc, 2022 Lynch C, Sakamuru S, Xia M.
europepmc +1 more source