Results 111 to 120 of about 8,905 (163)

Pregnane X receptor (PXR) as a prognostic marker and therapeutic target in kidney renal clear cell carcinoma (KIRC) via AMPK pathway regulation. [PDF]

Sci Rep
Hu WJ, Liu M, Bao YN, Su BW, Sui X, Cui XH, Wang GY, Wen L, Wen RK, Wang WH, Yang HX, Luan ZL.   +11 more
europepmc   +1 more source

Pregnane X Receptor and the Gut-Liver Axis: A Recent Update. [PDF]

Drug Metab Dispos, 2022
Dutta M, Lim JJ, Cui JY.
europepmc   +1 more source

Quantifying expression and metabolic activity of genes regulated by pregnane X receptor in primary human hepatocyte spheroids. [PDF]

PLoS Comput Biol
Lochman L, Kahiya ET, Saade B, Smutný T, Tebbens JD, Pávek P, Bernhauerová V.   +6 more
europepmc   +1 more source

LIM and SH3 protein 2 (Lasp2) is a novel pregnane X receptor target gene in mouse liver. [PDF]

Mol Pharmacol
Konzack A, Karpale M, Smutny T, Hassanen M, Lassila P, Ahonen MH, Elkhwanky MS, Kummu O, Pavek P, Hakkola J.   +9 more
europepmc   +1 more source

First-in-Class Small Molecule Degrader of Pregnane X Receptor Enhances Chemotherapy Efficacy. [PDF]

J Med Chem
Huber AD, Jung YH, Li Y, Lin W, Wu J, Poudel S, Carrigan AG, Mishra A, High AA, Chen T.   +9 more
europepmc   +1 more source

A two-in-one expression construct for biophysical and structural studies of the human pregnane X receptor ligand-binding domain, a pharmaceutical and environmental target. [PDF]

Acta Crystallogr F Struct Biol Commun
Carivenc C, Laconde G, Blanc P, Amblard M, Bourguet W, Delfosse V.   +5 more
europepmc   +1 more source

Activation of nuclear receptor pregnane-X-receptor protects against abdominal aortic aneurysm by inhibiting oxidative stress. [PDF]

Redox Biol
Shen Z, Wang J, Chen Y, Fang P, Yuan A, Chen AF, Yan X, Lyu Y, Pu J.   +8 more
europepmc   +1 more source

Pregnane X Receptor in Drug Development

, 2011
Su Sien, Yue-Ming Wang, Sergio C., Taosheng Che   +3 more
openaire   +2 more sources

Activation of pregnane X receptor protects against cholestatic liver injury by inhibiting hepatocyte pyroptosis. [PDF]

Acta Pharmacol Sin
Liang HF, Yang X, Li HL, Li X, Tian JN, Su HG, Huang M, Fang JH, Bi HC.   +8 more
europepmc   +1 more source

Commiphora myrrha resin extract-modulated cytochrome P-450 2C9 enzyme expression in cultured Hep G2 cells is associated with resin extract-derived metabolites binding to Pregnane X receptor. [PDF]

BMC Complement Med Ther
Alsharidah A, Alehaideb Z, Alghamdi SS, Suliman RS, Althenayyan S, Almourfi F, Hazazi B, Almogren A, Tuwaijri AA, Boudjelal M, Alkhuriji A, Matou-Nasri S.   +11 more
europepmc   +1 more source