Results 91 to 100 of about 10,479 (197)
Marine and Semi-Synthetic Hydroxysteroids as New Scaffolds for Pregnane X Receptor Modulation
Marine Drugs, 2014 In recent years many sterols with unusual structures and promising biological profiles have been identified from marine sources. Here we report the isolation of a series of 24-alkylated-hydroxysteroids from the soft coral Sinularia kavarattiensis, acting
Valentina Sepe +12 more
doaj +1 more source
Bilirubin as a Modulator of WNK1 Protein Signaling: Implications for Neuroinflammatory Diseases
Advanced Science, Volume 13, Issue 27, 13 May 2026.ABSTRACT Previously regarded merely as a potentially harmful waste product of heme catabolism, bilirubin has now emerged as a pleiotropic molecule with potent antioxidant, anti‐inflammatory, and hormone‐like properties. Recent findings have revealed protective effects against cardiovascular, metabolic, autoimmune, and neoplastic diseases, as well as ...
Sri Jayanti +3 more
wiley +1 more source
, 2012 L'exposition à des contaminants environnementaux est suspectée de perturber les fonctions endocrino-métaboliques des organismes et contribuer au développement de pathologies métaboliques comme le diabète et la stéatose hépatique non alcoolique.
Marmugi, Alice
core
Probing the Biological Plausibility of Fluoride as an Endocrine Disruptor
Birth Defects Research, Volume 118, Issue 5, May 2026.ABSTRACT Background Fluoride has come under recent scrutiny regarding concerns over potential neurodevelopmental and endocrine‐related toxicities, with recent reviews by the National Toxicology Program (NTP) and European Food Safety Authority (EFSA) concluding with moderate or reasonable confidence, respectively, that exposure to drinking water having ...
Ashley M. Mudd +2 more
wiley +1 more source
, 2009 Acetaminophen (APAP) is safe at therapeutic levels but causes hepatotoxicity via N-acetyl-p-benzoquinone imine-induced oxidative stress upon overdose. To determine the effect of human (h) pregnane X receptor (PXR) activation and CYP3A4 induction on APAP ...
Ma, Xiaochao +4 more
core +1 more source
Food Science &Nutrition, Volume 14, Issue 5, May 2026.Lactiplantibacillus plantarum CQPC03 could reduce carrageenan‐induced thrombosis in mice. ABSTRACT This investigation reports the effects of Lactiplantibacillus plantarum CQPC03 (LP‐CQPC03) on preventing thrombus formation and reducing intestinal oxidative stress and inflammation in a carrageenan‐induced mouse thrombosis model. High‐throughput 16S rRNA
Xin Zhao +6 more
wiley +1 more source
The Nuclear Pregnane X Receptor Regulates Xenobiotic Detoxification [PDF]
The Journal of Nutrition, 2003 The pregnane X receptor (PXR), which is a member of the nuclear receptor family of ligand-activated transcription factors, is an integral component of the body's defense mechanism against toxic xenobiotics. PXR is activated by a broad spectrum of lipophilic xenobiotics including prescription drugs, herbs, pesticides, endocrine disruptors and other ...
openaire +2 more sources
New aspects of pregnane X receptor function and regulation [PDF]
, 2018 Charles University, Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Candidate: Lucie Hyršová, MSc. First Supervisor: doc. PharmDr. František Trejtnar, CSc. Consultant: prof. PharmDr. Petr Pávek, PhD.
Hyršová, Lucie
core
, 2016 Great research effort has been focused on elucidating the contribution of host genetic variability on pharmacological outcomes in cancer. Nuclear receptors have emerged as mediators between environmental stimuli and drug pharmacokinetics and ...
RONCATO, ROSSANA +3 more
core +1 more source
Stem Cell Research, 2018 Pregnane X receptor (PXR) is a key nuclear receptor that mediates drug metabolism and stimulates hepatocyte proliferation. However, the lack of PXR expression in human pluripotent stem cell-derived hepatocytes limits their application for drug screening ...
Hyemin Kim +5 more
doaj +1 more source