Results 81 to 90 of about 10,479 (197)

Regulation of xenobiotic and bile acid metabolism by the nuclear pregnane X receptor

Journal of Lipid Research, 2002
The nuclear pregnane X receptor (PXR; NR1I2) is an integral component of the body's defense mechanism against chemical insult (chemoprotection). PXR is activated by a diverse array of lipophilic chemicals, including xenobiotics and endogenous substances,
Steven A. Kliewer, Timothy M. Willson
doaj   +1 more source

The Effects of Pregnenolone 16α-Carbonitrile Dosing on Digoxin Pharmacokinetics and Intestinal Absorption in the Rat

, 2010
pharmaceutic
Lowes, Simon, Anna-lena Ungell, Nicholas L. Simmons, Haslam, Iain S., Johan E. Karlsson, Iain S. Haslam, Ungell, Anna-Lena, Hilgendorf, Constanze, Ungell, Anna Lena, Simon Lowes, Fihn, Britt-Marie, Simmons, Nicholas L., Constanze Hilgendorf, Fihn, Britt Marie, Britt-marie Fihn, Karlsson, Johan E.   +15 more
core   +1 more source

Characterization of porcine pregnane X receptor, farnesoid X receptor and their splice variants

Experimental Biology and Medicine, 2010
The pregnane X receptor (PXR; NR1I2) and the farnesoid X receptor (FXR; NR1H4) regulate the expression of many major metabolic enzymes. With the pig being used as a model for humans in metabolic and toxicological studies and also an important food animal, we characterized the transactivation profile of the porcine orthologs of these receptors, pgPXR ...
Matthew A, Gray, Callie B, Pollock, Lawrence B, Schook, E James, Squires   +3 more
openaire   +2 more sources

Probiotics mixture reinforces barrier function to ameliorate necrotizing enterocolitis by regulating PXR-JNK pathway

Cell & Bioscience, 2021
Background Intestinal dysbiosis is believed to be one of the factors inducing neonatal necrotizing enterocolitis (NEC). Probiotics have been employed to treat NEC in a number of animal experiments and clinical trials, and some significant benefits of ...
Xiuhao Zhao, Jin Zhou, Wenhua Liang, Qingfeng Sheng, Li Lu, Tong Chen, Jianglong Chen, Kezhe Tan, Zhibao Lv   +8 more
doaj   +1 more source

NUBIScan, an in silico approach for prediction of nuclear receptor response elements [PDF]

, 2002
Nuclear receptors (NRs) are transcription factors activated by a multitude of hormones, other endogenous substances, and exogenous molecules. These proteins modulate the regulation of target genes by contacting their promoter or enhancer sequences at ...
Kaufmann, M. R., Handschin, C., Meyer, U. A., Podvinec, M.   +3 more
core  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, Volume 20, Issue 6, Page 1494-1512, June 2026.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Bile acid metabolism and sleep: Mechanistic interplay and clinical implications of the gut–liver–brain axis

Sleep Research, Volume 3, Issue 2, Page 170-179, June 2026.
Abstract The bidirectional interplay between sleep and metabolic homeostasis is fundamental to physiological health. While the roles of glucose and lipid metabolism in sleep regulation have been extensively characterized, bile acids (BAs), which are traditionally viewed as digestive surfactants, are emerging as critical metabolic messengers with ...
Yu Jiang, Shuangyan Li, Dhirendra Paudel, Miaoqin Tan, Bin Zhang   +4 more
wiley   +1 more source

Functional evolution of the vitamin D and pregnane X receptors [PDF]

BMC Evolutionary Biology, 2007
AbstractBackgroundThe vitamin D receptor (VDR) and pregnane X receptor (PXR) are nuclear hormone receptors of the NR1I subfamily that show contrasting patterns of cross-species variation. VDR and PXR are thought to have arisen from duplication of an ancestral gene, evident now as a single gene in the genome of the chordate invertebrateCiona ...
Ou Junhai, Mada Sripal R, Bahary Nathan, Hagey Lee R, Mattos Jaco, Bainy Afonso, Reschly Erica J, Venkataramanan Raman, Krasowski Matthew D   +8 more
openaire   +3 more sources

Insight into the molecular recognition of human and polar bear pregnane X receptor by three organic pollutants using molecular docking and molecular dynamics simulations

Environment International
Pregnane X receptor (PXR) is a heterologous biosensor that is involved in the metabolic pathway of environmental pollutants, regulating the transcription of genes involved in biotransformation.
Ruige Wang, Yaqi Lin, Ying Sun, Bing Zhao, Lin Chen   +4 more
doaj   +1 more source

CYP2E1 and CYP2D6 in Anti‐Tuberculosis Drug‐Induced Liver Injury: Mechanisms, Epigenetic Regulation, and Translational Implications

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
ABSTRACT Tuberculosis (TB) continues to be a significant global health issue, with anti‐tuberculosis drug‐induced liver injury (ATDILI) representing the most frequent and severe adverse event associated with first‐line therapy. Despite extensive investigation, the mechanistic basis of ATDILI remains incompletely understood.
Pathida Prakongsup, Wanvisa Udomsinprasert   +1 more
wiley   +1 more source