Results 81 to 90 of about 8,905 (163)
Journal of Mass Spectrometry, Volume 61, Issue 8, August 2026.ABSTRACT Organotin (IV) compounds are known to induce apoptosis via the intrinsic mitochondrial pathway, which is a key mechanism of effective anticancer therapy. Their ability to selectively promote apoptotic cell death highlights their potential as chemotherapeutic agents. In this study, the in vitro effects of two triorganotin compounds, tributyltin
Dana Strouhalova +3 more
wiley +1 more source
Medications That Regulate Pregnane X Receptor: A Systematic Review of Current Evidence
Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.PRISMA 2020 flow diagram of study selection for this systematic review of medications that regulate the pregnane X receptor (PXR), from 12 236 records screened to 101 included studies. ABSTRACT The pregnane X receptor (PXR) gene encodes a ligand‐activated protein involved with the metabolism and excretion of drugs, toxins, and other xenobiotics.
Petra Czarniak +4 more
wiley +1 more source
The FASEB Journal, Volume 40, Issue 14, 31 July 2026.Partial hepatectomy (PH) reshapes gut microbiota composition, resulting in the release of microbial metabolites and components, including short chain fatty acids (SCFAs)/β‐hydroxybutyric acid (BHB), bacterial DNA and extracellular vesicles (EVs), bile acids (deoxycholic acid, DCA), and aminobenzoate degradation products.
Roberto Loi +3 more
wiley +1 more source
Pregnane X Receptor and Cancer: Context-Specificity is Key
Nuclear Receptor Research, 2016 Pregnane X receptor (PXR) is an adopted orphan nuclear receptor that is activated by a wide-range of endobiotics and xenobiotics, including chemotherapy drugs. PXR plays a major role in the metabolism and clearance of xenobiotics and endobiotics in liver and intestine via induction of drug-metabolizing enzymes and drug-transporting proteins.
Satyanarayana R, Pondugula +2 more
openaire +2 more sources
Stem Cell Research, 2018 Pregnane X receptor (PXR) is a key nuclear receptor that mediates drug metabolism and stimulates hepatocyte proliferation. However, the lack of PXR expression in human pluripotent stem cell-derived hepatocytes limits their application for drug screening ...
Hyemin Kim +5 more
doaj +1 more source
Bisphenol F and Steatotic Liver Disease: Resolving the PXR Paradox Through Stress Pathway Mechanisms
BiomedicinesSteatotic liver disease (SLD) represents a major global health burden, with environmental toxicants emerging as critical contributors alongside metabolic dysfunction.
Enwar Abdalkarim AbdalHussin +4 more
doaj +1 more source
Research Progress in Bile Acid Receptor-Mediated Improvement of Intestinal Health by Natural Products [PDF]
Shipin KexueBile acids play an important role in intestinal health, and an imbalance in bile acid homeostasis is closely related to intestinal diseases such as inflammatory bowel disease, irritable bowel syndrome, bile acid diarrhea, and colorectal cancer.
LIU Qi, CHEN Siyang, HAN Xiaoqian, LI Shuting, HAN Feifei
doaj +1 more source
PLoS ONE, 2019 BACKGROUND:The Pregnane X Receptor (PXR) is a principal signal transducer in mucosal responses to xenobiotic stress. It is well-recognized that inflammatory bowel disease is accompanied by xenobiotic stress, but the importance of the PXR in limiting ...
J Jasper Deuring +7 more
doaj +1 more source
Adverse outcome pathway for pregnane X receptor-induced hypercholesterolemia. [PDF]
Arch Toxicol, 2023 Itkonen A, Hakkola J, Rysä J.
europepmc +1 more source
Advances in drug resistance of triple negative breast cancer caused by pregnane X receptor. [PDF]
World J Clin Oncol, 2023 Rao ZZ, Tang ZW, Wen J.
europepmc +1 more source