Results 101 to 110 of about 10,479 (197)

The role of pregnane-X-receptor in liver fibrosis

, 2007
Liver fibrosis is a wound healing response to chronic hepatocellular damage. The activated pregnane X receptor has been shown to exert an anti-fibrogenic effect in rodent chronic liver injury in vivo models.
Haughton, E L
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Phosphorylation Modulates the Coregulatory Protein Exchange of the Nuclear Receptor Pregnane X Receptor

, 2020
The pregnane X receptor (PXR), or nuclear receptor (NR) 1I2, is a ligand-activated NR superfamily member that is enriched in liver and intestine in mammals.
Shen, Xunan, Agbas, Emre, Cameron-Carter, Hadley, Tompkins, Brandon, Staudinger, Jeff, Cui, Wenqi   +5 more
core   +1 more source

Non-genomic effects of the Pregnane X Receptor negatively regulate platelet functions, thrombosis and haemostasis [PDF]

, 2019
The pregnane X receptor (PXR) is a nuclear receptor (NR), involved in the detoxification of xenobiotic compounds. Recently, its presence was reported in the human vasculature and its ligands were proposed to exhibit anti-atherosclerotic effects.
Holbrook, LM, Crescente, M, Unsworth, AJ, Stainer, Alex R., Crescente, Marilena, Unsworth, Amanda J., Sahli, Khaled A., Stainer, AR, Sahli, KA, AlOuda, SK, Flora, Gagan D., Holbrook, Lisa-Marie, Sage, T, Flora, GD, Alouda, Sarah K., Holbrook, L-M, Sasikumar, Parvathy, Sage, Tanya, Gibbins, JM, Gibbins, Jon M., Sasikumar, P   +20 more
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Bisphenol F and Steatotic Liver Disease: Resolving the PXR Paradox Through Stress Pathway Mechanisms

Biomedicines
Steatotic liver disease (SLD) represents a major global health burden, with environmental toxicants emerging as critical contributors alongside metabolic dysfunction.
Enwar Abdalkarim AbdalHussin, Zariyantey Abd Hamid, Muhd Hanis Md Idris, Maizatul Hasyima Omar, Izatus Shima Taib   +4 more
doaj   +1 more source

Research Progress in Bile Acid Receptor-Mediated Improvement of Intestinal Health by Natural Products [PDF]

Shipin Kexue
Bile acids play an important role in intestinal health, and an imbalance in bile acid homeostasis is closely related to intestinal diseases such as inflammatory bowel disease, irritable bowel syndrome, bile acid diarrhea, and colorectal cancer.
LIU Qi, CHEN Siyang, HAN Xiaoqian, LI Shuting, HAN Feifei
doaj   +1 more source

Pregnane X receptor activation constrains mucosal NF-κB activity in active inflammatory bowel disease.

PLoS ONE, 2019
BACKGROUND:The Pregnane X Receptor (PXR) is a principal signal transducer in mucosal responses to xenobiotic stress. It is well-recognized that inflammatory bowel disease is accompanied by xenobiotic stress, but the importance of the PXR in limiting ...
J Jasper Deuring, Meng Li, Wanlu Cao, Sunrui Chen, Wenshi Wang, Colin de Haar, C Janneke van der Woude, Maikel Peppelenbosch   +7 more
doaj   +1 more source

The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution

, 2000
Transcription of genes encoding cytochrome P 450 3A (CYP3A) monooxygenases is induced by a variety of xenobiotics and natural steroids. There are marked differences in the compds. that induce CYP3A gene expression between species. Recently, the mouse and
Linda B. Moore, Edward L. LeCluyse, Millard H. Lambert, Stacey A. Jones, Jones, Stacey A., Nicholas C. O. Tomkinson, Kliewer, Steven A., LeCluyse, Edward L., Tomkinson, Nicholas C. O., G. Bruce Wisely, Shenk, Jennifer L., Moore, John T., Wisely, G. Bruce, Moore, Linda B., Geraldine A. Hamilton, John T. Moore, Jennifer L. Shenk, Steven A. Kliewer, David D. McKee, Lambert, Millard H., Timothy M. Willson, Hamilton, Geraldine A., McKee, David D., Willson, Timothy M.   +23 more
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An investigation of Cytochrome P450 function in human cell Lines for potential use in a bioartificial liver device

, 2010
Bioartificial Liver Devices (BAL) could provide hepatic function in patients with liver failure awaiting transplantation or liver regeneration. Certain BALs use human hepatoblastoma-derived HepG2 cells that can perform many hepatocyte specific ...
Thomas, A.
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IN SILICO IDENTIFICATION OF HUMAN PREGNANE X RECEPTOR ACTIVATORS [PDF]

, 2015
The nuclear receptor member human pregnane X receptor (hPXR) regulates enzymes and transporters involved in xenobiotic detoxification as well as maintains homeostatic balance of bile acids, thyroid and steroid hormones.
Milen P. Todorov
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The impact of pregnane X receptor activation on liver fibrosis

, 2006
The PXR (pregnane X receptor) is a nuclear receptor transcription factor that is activated by a range of endobiotics and xenobiotics. The activated PXR modulates the transcription of genes in hepatocytes (the main functional cell of the liver) associated
Wright MC
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