Results 61 to 70 of about 10,479 (197)

Expressão dos genes Receptor Pregnano X (PXR), Citocromo P4503A (CYP3A) e resistência a multidrogas 1(MDR1) em fígado de peixe-zebra (Danio rerio) [PDF]

, 2005
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Biotecnologia.O receptor pregnano X (PXR) é um receptor nuclear envolvido na regulação transcricional de enzimas envolvidas no ...
Bresolin, Taise
core  

Mode‐of‐Action and Human Relevance Assessment for Diisononyl Phthalate‐Induced Liver Tumors in Rodents

Journal of Applied Toxicology, EarlyView.
ABSTRACT Diisononyl phthalate (DINP) is a high molecular weight phthalate and high production volume chemical. DINP's carcinogenic potential has been investigated in four rodent bioassays, with liver tumors observed in three of the studies. Authoritative assessments have hypothesized that DINP acts through the peroxisome proliferator‐activated receptor
Amanda N. Buerger, Melissa M. Heintz, Laurie C. Haws, Chad M. Thompson   +3 more
wiley   +1 more source

An optimized protocol with a stepwise approach to identify specific nuclear receptor ligands from cultured mammalian cells

STAR Protocols, 2021
Summary: Here, we describe an optimized protocol to identify specific nuclear receptor ligands. First, to rule out any compound interference with luciferase activity per se, we describe an in vitro assay assessing potential inhibition or activation of ...
Alexandre Berthier, Bart Staels, Philippe Lefebvre   +2 more
doaj   +1 more source

Endoscopic Treatment for Esophagogastric Variceal Bleeding in Patients With Acute‐on‐Chronic Liver Failure: An Observational Study

Portal Hypertension &Cirrhosis, EarlyView.
In patients with acute‐on‐chronic liver failure (ACLF), esophagogastric variceal bleeding (EGVB) represents a critical complication associated with high short‐term mortality. This study evaluated the efficacy of endoscopic treatment in this specific population and identified prognostic factors associated with 6‐week rebleeding and mortality.
Yanan Sun, Peng Li, Shibin Zhang, Yuening Zhang, Chunlei Fan, Ajuan Zeng, Yanna Liu, Huiguo Ding   +7 more
wiley   +1 more source

Modulation of T Lymphocyte Function by the Pregnane X Receptor [PDF]

The Journal of Immunology, 2010
Abstract The pregnane X receptor (PXR) is a ligand-activated transcription factor regulating genes central to drug and hormone metabolism in the liver. Previous reports indicated that PXR is expressed in PBMC, but the role of PXR in immune cells remains unknown.
Sandrine, Dubrac, Andreas, Elentner, Susanne, Ebner, Jutta, Horejs-Hoeck, Matthias, Schmuth   +4 more
openaire   +2 more sources

Efeito de ligantes dos receptores nucleares PXR e VDR na expressão de genes de biotransformação no fígado e intestino de peixes Danio rerio [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Bioquímica, Florianópolis, 2010O receptor de Vitamina D (VDR) e o receptor Pregnano X (PXR) são receptores nucleares e agem como ...
Siebert, Marília Nardelli
core  

Crossroads between drug and energy metabolism : role of constitutive androstane receptor and AMP-activated kinase [PDF]

, 2010
Phenobarbital (PB) is a prototype inducer of genes encoding drug metabolizing enzymes including the cytochromes P450 (CYPs). Additionally, phenobarbital was found to repress genes that encode enzymes involved in gluconeogenesis such as ...
Harach, Taoufiq
core   +1 more source

Current Cell/Organoid and Animal Models for Primary Sclerosing Cholangitis

Portal Hypertension &Cirrhosis, EarlyView.
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease with limited therapeutic options and a marked risk of progression to biliary fibrosis, cirrhosis, and malignancy. Progress in PSC research has been hindered by the lack of models that faithfully recapitulate the complex biliary microenvironment and disease heterogeneity ...
Qigu Yao, Sheng Cheng, Qiaoling Pan, Jiong Yu, Hongcui Cao   +4 more
wiley   +1 more source

Nuclear Receptors as Targets for Drug Development: Regulation of Cholesterol and Bile Acid Metabolism by Nuclear Receptors

Journal of Pharmacological Sciences, 2005
Nuclear receptors are ligand-dependent transcription factors that recently have been shown to play important roles in the metabolism of cholesterol and bile acids.
Makoto Makishima
doaj   +1 more source

Construction of an O2‐responsive engineering bioreactor for enhanced indole‐3‐propionic acid production and deoxynivalenol detoxification

Responsive Materials, EarlyView.
An oxygen‐responsive living bioreactor was engineered via interspecies protoplast fusion, converting oxygen from an inhibitory stress into a programmable signal for sustained indole‐3‐propionic acid (IPA) production. This genetically encoded bioreactor enables robust aerobic operation and therapeutic efficacy of deoxynivalenol detoxification in vivo ...
Ning Ma, Jiakun Shen, Kun Cai, Wenxi Zhao, Chuan Feng, Xingyao Wang, Yangyang Liu, Dongyan Zhang, Xi Ma   +8 more
wiley   +1 more source