Results 71 to 80 of about 10,479 (197)

Pregnane X receptor knockout mice display aging-dependent wearing of articular cartilage.

PLoS ONE, 2015
Steroid and xenobiotic receptor (SXR) and its murine ortholog, pregnane X receptor (PXR), are nuclear receptors that are expressed at high levels in the liver and the intestine where they function as xenobiotic sensors that induce expression of genes ...
Kotaro Azuma, Stephanie C Casey, Tomohiko Urano, Kuniko Horie-Inoue, Yasuyoshi Ouchi, Bruce Blumberg, Satoshi Inoue   +6 more
doaj   +1 more source

Regulation of bile acid receptor activity

Liver Research, 2018
Many receptors can be activated by bile acids (BAs) and their derivatives. These include nuclear receptors farnesoid X receptor (FXR), pregnane X receptor (PXR), and vitamin D receptor (VDR), as well as membrane receptors Takeda G protein receptor 5 ...
Yu-Jui Yvonne Wan, Lili Sheng
doaj   +1 more source

The emerging role of the Hippo signaling pathway in interorgan crosstalk

The FEBS Journal, EarlyView.
Hippo signaling functions as a central hub of interorgan communication. Systemic cues from the gut, adipose tissue, and skeletal muscle—including hormones, metabolites, and microbial signals—regulate YAP/TAZ activity in a tissue‐ and context‐dependent manner.
Gahyeon Song, Chaerin Lee, Eek‐hoon Jho   +2 more
wiley   +1 more source

Novel plant inducers of PXR-dependent cytochrome P450 3A4 expression in HepG2 cells

Saudi Pharmaceutical Journal, 2018
The cytochrome P450 3A4 (CYP3A4) is the most abundant CYP450 enzyme involved in the metabolism of endogenous products and xenobiotics, including prescription drugs and herbals.
Mohammed S. Al-Dosari, Mohammad K. Parvez   +1 more
doaj   +1 more source

Glucocorticoids modulate drug transporter function in human fetal brain endothelial cells

The Journal of Physiology, EarlyView.
Abstract figure legend P‐glycoprotein and breast cancer resistance protein are the most prominent drug transporters at the fetal blood–brain barrier. We isolated primary human fetal brain endothelial cells from early and mid‐gestation cerebral microvessels and exposed them to glucocorticoids cortisol and dexamethasone in vitro.
Nikola Ivanovski, Phetcharawan Lye, Enrrico Bloise, Stephen G. Matthews   +3 more
wiley   +1 more source

Promoter DNA methylation of farnesoid X receptor and pregnane X receptor modulates the intrahepatic cholestasis of pregnancy phenotype.

PLoS ONE, 2014
The intrahepatic cholestasis of pregnancy (ICP) is a multifactorial liver disorder which pathogenesis involves the interplay among abnormal bile acid (BA) levels, sex hormones, environmental factors, and genetic susceptibility.
Romina Cabrerizo, Gustavo O Castaño, Adriana L Burgueño, Tomas Fernández Gianotti, María Mora Gonzalez Lopez Ledesma, Diego Flichman, Carlos J Pirola, Silvia Sookoian   +7 more
doaj   +1 more source

A review of xenobiotic membrane transporter expression within the human placenta: Lessons gained from primary tissue and in vitro methodologies

The Journal of Physiology, EarlyView.
Abstract figure legend A summary of the current knowledge around membrane transporter expression in the most widely used in vitro models of human trophoblasts, including primary placental tissue, cancer cell lines and trophoblast stem cells, as well as the techniques to attempt to mimic the human placenta in vivo.
Rhiannon Pass, Kathryn Wolton, Amanda N. Sferruzzi‐Perri   +2 more
wiley   +1 more source

Enhanced Acetaminophen Toxicity by Activation of the Pregnane X Receptor [PDF]

Toxicological Sciences, 2004
The pregnane X receptor (PXR) is a ligand-activated transcription factor and member of the nuclear receptor superfamily. Activation of PXR represents an important mechanism for the induction of cytochrome P450 3A (CYP3A) enzymes that can convert acetaminophen (APAP) to its toxic intermediate metabolite, N-acetyl-p-benzoquinone imine (NAPQI). Therefore,
Grace L, Guo, Jeff S, Moffit, Christopher J, Nicol, Jerrold M, Ward, Lauren A, Aleksunes, Angela L, Slitt, Steven A, Kliewer, Jose E, Manautou, Frank J, Gonzalez   +8 more
openaire   +2 more sources

Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor

, 2019
Pregnane X receptor (PXR) is a master xenobiotic-sensing transcription factor with a key role in drug metabolism and disposition. Its activity regulates a number of physiological processes in the liver and intestine, and it is now a validated target for ...
Francesco, Galli, Riccardo, Ronchetti, Antonella, De Luca, Desirée, Bartolini, Arne, Schön, Matthew R., Redinbo, Samuel J., Pellock, Roberto, Pellicciari, Bruno, Cerra, Rita, Marinelli, Francesca, Fallarino, Francesca, De Franco, Pierangelo, Torquato, Angelo, Sidoni, Sridhar, Mani, Antimo, Gioiello, Ivana, Ferri, Guido, Bellezza, William G., Walton   +18 more
core   +1 more source

Suppression of the Nrf2-dependent antioxidant response by glucocorticoids and 11β-HSD1-mediated glucocorticoid activation in hepatic cells [PDF]

, 2012
Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a key transcription factor regulating a plethora of detoxifying enzymes and antioxidant genes involved in drug metabolism and defence against oxidative stress.
Denise V. Kratschmar (165140), Diego Calabrese, Diego Calabrese (165146), Moulin, Pierre, Birk, Julia, Pierre Moulin, Appenzeller-Herzog, Christian, Calabrese, Diego, Christian Appenzeller-Herzog (165171), Lister Adam, Lister, Adam, Alex Odermatt (27423), Pierre Moulin (106353), Adam Lister (165158), Walsh Jo, Appenzeller-Herzog Christian, Moulin Pierre, Goldring Chris E., Chris E. Goldring (165179), Birk Julia, Jo Walsh, Jo Walsh (165152), Chris E Goldring, Kratschmar, Denise V., Denise V Kratschmar, Calabrese Diego, Goldring, Chris E., Kratschmar Denise V., Walsh, Jo, Julia Birk, Julia Birk (165165), Alex Odermatt, Odermatt Alex, Adam Lister, Odermatt, Alex, Christian Appenzeller-Herzog   +35 more
core   +1 more source