A Possible Link Between Pyriproxyfen and Microcephaly [PDF]
arXiv, 2016 The Zika virus is the primary suspect in the large increase in microcephaly cases in 2015-6 in Brazil, however its role is unconfirmed despite individual cases of viral infections found in neural tissue. Here we consider the alternative that the insecticide pyriproxyfen, used in Brazilian drinking water for mosquito control, may actually be the cause ...
arxiv
A Role of the Bile Salt Receptor FXR in Atherosclerosis [PDF]
, 2010 This study reviews current insights into the role of bile salts and bile salt receptors on the progression and regression of atherosclerosis. Bile salts have emerged as important modifiers of lipid and energy metabolism.
Groen, A.K. +3 more
core +3 more sources
Deficiency of Capicua disrupts bile acid homeostasis [PDF]
, 2018 Capicua (CIC) has been implicated in pathogenesis of spinocerebellar ataxia type 1 and cancer in mammals; however, the in vivo physiological functions of CIC remain largely unknown.
Choi, N +12 more
core +2 more sources
Steroid Receptors and Vertebrate Evolution [PDF]
arXiv, 2019 Considering that life on earth evolved about 3.7 billion years ago, vertebrates are young, appearing in the fossil record during the Cambrian explosion about 542 to 515 million years ago. Results from sequence analyses of genomes from bacteria, yeast, plants, invertebrates and vertebrates indicate that receptors for adrenal steroids (aldosterone ...
arxiv
Orphan Nuclear Receptors Constitutive Androstane Receptor and Pregnane X Receptor Share Xenobiotic and Steroid Ligands [PDF]
, 2000 Linda B. Moore +11 more
openalex +1 more source
Activation of Steroid and Xenobiotic Receptor (SXR, NR1I2) and Its Orthologs in Laboratory Toxicologic, and Genome Model Species [PDF]
, 2008 Background: Nuclear receptor subfamily 1, group I, member 2 (NR1I2), commonly known as steroid xenobiotic receptor (SXR) in humans, is a key ligand-dependent transcription factor responsible for the regulation of xenobiotic, steroid, and bile acid ...
Adriana Garcia +13 more
core +4 more sources
STAR Protocols, 2021 Summary: Here, we describe an optimized protocol to identify specific nuclear receptor ligands. First, to rule out any compound interference with luciferase activity per se, we describe an in vitro assay assessing potential inhibition or activation of ...
Alexandre Berthier +2 more
doaj
Identify of a tilapia pheromone released by dominant males that primes females for reproduction [PDF]
, 2014 Knowledge of the chemical identity and role of urinary pheromones in fish is scarce, yet necessary to understand the integration of multiple senses in adaptive responses and the evolution of chemical communication.
Adelino V.M. Canario +28 more
core +1 more source
Accuracy of direct gradient sensing by cell-surface receptors [PDF]
arXiv, 2009 Chemotactic cells of eukaryotic organisms are able to accurately sense shallow chemical concentration gradients using cell-surface receptors. This sensing ability is remarkable as cells must be able to spatially resolve small fractional differences in the numbers of particles randomly arriving at cell-surface receptors by diffusion.
arxiv
The Pregnane X Receptor: A Promiscuous Xenobiotic Receptor That Has Diverged during Evolution [PDF]
, 2000 S. A. Jones
openalex +1 more source