Results 11 to 20 of about 16,876 (211)

The Pregnane-X receptor regulates steroid synthesis in mouse Leydig cells [PDF]

Frontiers in Endocrinology
IntroductionPregnane X Receptor (PXR, NR1I2) is a ligand-dependent transcription factor belonging to the nuclear receptor superfamily, that can be activated by a wide variety of endogenous and exogenous ligands.
Emmanuelle Martinot, Hélène Holota, Angélique de Haze, Claude Beaudoin, David H. Volle   +4 more
doaj   +2 more sources

The pregnane X receptor: from bench to bedside [PDF]

Expert Opinion on Drug Metabolism & Toxicology, 2008
The pregnane X receptor (PXR; NR1I2), a member of the nuclear receptor superfamily, regulates the expression of metabolic enzymes and transporters involved in the response of mammals to their chemical environment.To summarize the functions and clinical implications of PXR.In the current review, the clinical implications of PXR are discussed, and the ...
Xiaochao, Ma, Jeffrey R, Idle, Frank J, Gonzalez   +2 more
openaire   +4 more sources

Indole-3-propionic acid alleviates sepsis-associated acute liver injury by activating pregnane X receptor [PDF]

Molecular Medicine, 2023
Background The morbidity and mortality of sepsis are extremely high, which is a major problem plaguing human health. However, current drugs and measures for the prevention and treatment of sepsis have little effect.
Shuang Wang, Liangzhi Xiong, Zhihua Ruan, Xiaofang Gong, Yanrong Luo, Chengyi Wu, Yu Wang, Hui Shang, Jingyi Chen   +8 more
doaj   +2 more sources

Chemical basis of pregnane X receptor activators in the herbal supplement Gancao (licorice) [PDF]

Liver Research, 2022
Background and aims: The herbal supplement Gancao, also known as licorice, belongs to the genus Glycyrrhiza and has been used worldwide for its hepatoprotective effect. Recent studies have raised concerns about potential herb-drug interactions associated
Anqi Cheng, Saifei Lei, Junjie Zhu, Jie Lu, Mary F. Paine, Wen Xie, Xiaochao Ma   +6 more
doaj   +2 more sources

S-nitrosylation attenuates pregnane X receptor hyperactivity and acetaminophen-induced liver injury [PDF]

JCI Insight
Drug-induced liver injury (DILI), especially acetaminophen overdose, is the leading cause of acute liver failure. Pregnane X receptor (PXR) is a nuclear receptor and the master regulator of drug metabolism.
Qi Cui, Tingting Jiang, Xinya Xie, Haodong Wang, Lei Qian, Yanyan Cheng, Qiang Li, Tingxu Lu, Qinyu Yao, Jia Liu, Baochang Lai, Chang Chen, Lei Xiao, Nanping Wang   +13 more
doaj   +2 more sources

Pregnane X receptor reduces particulate matter-induced type 17 inflammation in atopic dermatitis [PDF]

Frontiers in Immunology
BackgroundEpidemiological evidence suggests that particulate matter (PM) exposure can trigger or worsen atopic dermatitis (AD); however, the underlying mechanisms remain unclear. Recently, pregnane X receptor (PXR), a xenobiotic receptor, was reported to
Ji Su Lee, Ji Su Lee, Youngae Lee, Youngae Lee, Youngae Lee, Sunhyae Jang, Sunhyae Jang, Sunhyae Jang, Jang-Hee Oh, Jang-Hee Oh, Jang-Hee Oh, Dong Hun Lee, Dong Hun Lee, Dong Hun Lee, Dong Hun Lee, Soyun Cho, Soyun Cho, Soyun Cho   +17 more
doaj   +2 more sources

Pregnane X receptor and constitutive androstane receptor modulate differently CYP3A-mediated metabolism in earlyand late-stage cholestasis [PDF]

World Journal of Gastroenterology, 2017
AIM: To ascertain whether cholestasis affects the expression of two CYP3A isoforms (CYP3A1 and CYP3A2) and of pregnane X receptor (PXR) and constitutive androstane receptor (CAR).
Albertoni, Laura, Baldo, Vincenzo, Baldovin, Tatjana, Carrara, Maria, DALLA POZZA, Arianna, De Martin, Sara, Floreani, Annarosa, Gabbia, Daniela, Lazzari, Roberta, Zigiotto, Giorgia   +9 more
core   +3 more sources

The 3ʹ-untranslated region contributes to the pregnane X receptor (PXR) expression down-regulation by PXR ligands and up-regulation by glucocorticoids

Acta Pharmaceutica Sinica B, 2020
Pregnane X receptor (PXR) is the major regulator of xenobiotic metabolism. PXR itself is controlled by various signaling molecules including glucocorticoids. Moreover, negative feed-back regulation has been proposed at the transcriptional level.
Tomas Smutny, Jan Dusek, Lucie Hyrsova, Jana Nekvindova, Alzbeta Horvatova, Stanislav Micuda, Sabine Gerbal-Chaloin, Petr Pavek   +7 more
doaj   +3 more sources

Pregnane X Receptor Regulates Human Endocrine System by Inducing Sex Hormone-Binding Globulin Expression. [PDF]

Basic Clin Pharmacol Toxicol
ABSTRACT Sex hormone–binding globulin (SHBG) is a sex hormone carrier. We aimed to characterize the role of pregnane X receptor (PXR), a major regulator of drug metabolism, in SHBG regulation. Serum SHBG was measured in four clinical trials (n = 61) and expression in in vitro experiments in human 3D hepatocyte spheroids and HepG2 cells.
Ahonen MH, Konzack A, Smutny T, Pavek P, Hakkola J, Hukkanen J.   +5 more
europepmc   +2 more sources

Function annotation of hepatic retinoid x receptor α based on genome-wide DNA binding and transcriptome profiling. [PDF]

, 2012
BackgroundRetinoid x receptor α (RXRα) is abundantly expressed in the liver and is essential for the function of other nuclear receptors. Using chromatin immunoprecipitation sequencing and mRNA profiling data generated from wild type and RXRα-null mouse ...
Fang, Jianwen, Fang, Yaping, He, Yuqi, Liu, Hui-Xin, Wan, Yu-Jui Yvonne, Zhan, Qi   +5 more
core   +9 more sources