Results 11 to 20 of about 18,065 (250)

Recent advances in gut microbiota metabolite regulation of hepatic pregnane X receptor [PDF]

Frontiers in Immunology
The pregnane X receptor (PXR), a key hepatic nuclear receptor, exhibits a highly plastic ligand-binding domain (LBD) that recognizes diverse endogenous and exogenous ligands, contributing to interindividual variations in xenobiotic metabolism and toxic ...
Tong Lin, Yang Chen, Linquan Liu, Tiesong Wu, Yan Qian, Baofen Jin   +5 more
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Identification of human pregnane X receptor antagonists utilizing a high-throughput screening platform [PDF]

Frontiers in Pharmacology
Pregnane X receptor (PXR) is a xenobiotic-sensing nuclear receptor with a well-established role in regulating drug metabolism and clearance. Recent studies have shown that PXR is involved in cell proliferation, apoptosis, immune response, and energy ...
Caitlin Lynch, Ryan Margolis, Jacob Niebler, Jameson Travers, Srilatha Sakamuru, Tongan Zhao, Carleen Klumpp-Thomas, Ruili Huang, Menghang Xia   +8 more
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Indole-3-propionic acid alleviates sepsis-associated acute liver injury by activating pregnane X receptor [PDF]

Molecular Medicine, 2023
Background The morbidity and mortality of sepsis are extremely high, which is a major problem plaguing human health. However, current drugs and measures for the prevention and treatment of sepsis have little effect.
Shuang Wang, Liangzhi Xiong, Zhihua Ruan, Xiaofang Gong, Yanrong Luo, Chengyi Wu, Yu Wang, Hui Shang, Jingyi Chen   +8 more
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The Pregnane-X receptor regulates steroid synthesis in mouse Leydig cells [PDF]

Frontiers in Endocrinology
IntroductionPregnane X Receptor (PXR, NR1I2) is a ligand-dependent transcription factor belonging to the nuclear receptor superfamily, that can be activated by a wide variety of endogenous and exogenous ligands.
Emmanuelle Martinot, Hélène Holota, Angélique de Haze, Claude Beaudoin, David H. Volle   +4 more
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Chemical basis of pregnane X receptor activators in the herbal supplement Gancao (licorice) [PDF]

Liver Research, 2022
Background and aims: The herbal supplement Gancao, also known as licorice, belongs to the genus Glycyrrhiza and has been used worldwide for its hepatoprotective effect. Recent studies have raised concerns about potential herb-drug interactions associated
Anqi Cheng, Saifei Lei, Junjie Zhu, Jie Lu, Mary F. Paine, Wen Xie, Xiaochao Ma   +6 more
doaj   +2 more sources

The Pregnane X Receptor and Indole-3-Propionic Acid Shape the Intestinal Mesenchyme to Restrain Inflammation and FibrosisSummary [PDF]

Cellular and Molecular Gastroenterology and Hepatology, 2023
Background & Aims: Fibrosis is a common complication of inflammatory bowel diseases (IBDs). The pregnane X receptor (PXR) (encoded by NR1I2) suppresses intestinal inflammation and has been shown to influence liver fibrosis.
Kyle L. Flannigan, Kristoff M. Nieves, Holly E. Szczepanski, Alex Serra, Joshua W. Lee, Laurie A. Alston, Hena Ramay, Sridhar Mani, Simon A. Hirota   +8 more
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Expanding the Library of 1,2,4-Oxadiazole Derivatives: Discovery of New Farnesoid X Receptor (FXR) Antagonists/Pregnane X Receptor (PXR) Agonists [PDF]

Molecules, 2023
Compounds featuring a 1,2,4-oxadiazole core have been recently identified as a new chemotype of farnesoid X receptor (FXR) antagonists. With the aim to expand this class of compounds and to understand the building blocks necessary to maintain the ...
Claudia Finamore, Carmen Festa, Bianca Fiorillo, Francesco Saverio Di Leva, Rosalinda Roselli, Silvia Marchianò, Michele Biagioli, Lucio Spinelli, Stefano Fiorucci, Vittorio Limongelli, Angela Zampella, Simona De Marino   +11 more
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S-nitrosylation attenuates pregnane X receptor hyperactivity and acetaminophen-induced liver injury [PDF]

JCI Insight
Drug-induced liver injury (DILI), especially acetaminophen overdose, is the leading cause of acute liver failure. Pregnane X receptor (PXR) is a nuclear receptor and the master regulator of drug metabolism.
Qi Cui, Tingting Jiang, Xinya Xie, Haodong Wang, Lei Qian, Yanyan Cheng, Qiang Li, Tingxu Lu, Qinyu Yao, Jia Liu, Baochang Lai, Chang Chen, Lei Xiao, Nanping Wang   +13 more
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Pregnane X receptor reduces particulate matter-induced type 17 inflammation in atopic dermatitis [PDF]

Frontiers in Immunology
BackgroundEpidemiological evidence suggests that particulate matter (PM) exposure can trigger or worsen atopic dermatitis (AD); however, the underlying mechanisms remain unclear. Recently, pregnane X receptor (PXR), a xenobiotic receptor, was reported to
Ji Su Lee, Ji Su Lee, Youngae Lee, Youngae Lee, Youngae Lee, Sunhyae Jang, Sunhyae Jang, Sunhyae Jang, Jang-Hee Oh, Jang-Hee Oh, Jang-Hee Oh, Dong Hun Lee, Dong Hun Lee, Dong Hun Lee, Dong Hun Lee, Soyun Cho, Soyun Cho, Soyun Cho   +17 more
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Myeloid-specific deficiency of pregnane X receptor decreases atherosclerosis in LDL receptor-deficient mice[S]

Journal of Lipid Research, 2020
The pregnane X receptor (PXR) is a nuclear receptor that can be activated by numerous drugs and xenobiotic chemicals. PXR thereby functions as a xenobiotic sensor to coordinately regulate host responses to xenobiotics by transcriptionally regulating many
Yipeng Sui, Zhaojie Meng, Se-Hyung Park, Weiwei Lu, Christopher Livelo, Qi Chen, Tong Zhou, Changcheng Zhou   +7 more
doaj   +2 more sources