Results 31 to 40 of about 235,181 (316)

Pregnane X Receptor in Drug Development [PDF]

, 2011
Sergio C. Chai, Su Sien Ong, Taosheng Chen, Yue-Ming Wang   +3 more
core   +5 more sources

Pregnane X Receptor‒4β-Hydroxycholesterol Axis in the Regulation of Overweight- and Obesity-Induced Hypertension. [PDF]

J Am Heart Assoc, 2022
Background Mechanisms mediating hypertensive effects of overweight and obesity have not been fully elucidated. We showed previously that activation of pregnane X receptor (PXR) by rifampicin elevates 24‐hour blood pressure (BP) and plasma 4β ...
Rahunen R, Kummu O, Koivukangas V, Hautajärvi H, Hakkola J, Rysä J, Hukkanen J.   +6 more
europepmc   +2 more sources

Cannabidiol promotes intestinal cholesterol uptake mediated by Pregnane X receptor. [PDF]

Front Endocrinol (Lausanne)
BackgroundCannabidiol (CBD), a non-psychoactive phytocannabinoid of cannabis, is therapeutically used as an analgesic, anti-convulsant, anti-inflammatory, and anti-psychotic drug.
Brown C, Kariuki W, Zhong HA, Kippes A, Sui Y.   +4 more
europepmc   +2 more sources

Indole-3-propionic acid alleviates sepsis-associated acute liver injury by activating pregnane X receptor. [PDF]

Mol Med, 2023
Background The morbidity and mortality of sepsis are extremely high, which is a major problem plaguing human health. However, current drugs and measures for the prevention and treatment of sepsis have little effect.
Wang S, Xiong L, Ruan Z, Gong X, Luo Y, Wu C, Wang Y, Shang H, Chen J.   +8 more
europepmc   +2 more sources

Forsythiaside A Reduces Acetaminophen Hepatotoxic Metabolism by Inhibiting Pregnane X Receptor. [PDF]

Molecules
Overdose intake of acetaminophen (APAP) causes liver injury involving hepatic drug metabolism and activation of oxidative stress pathways, and forsythiaside A (FA) has hepatoprotective pharmacological activity, but knowledge of the mechanism of FA ...
Pu S, Pan Y, Wang Z, Liu H, Zhang J, Zhang Q, Wang M.   +6 more
europepmc   +2 more sources

Identification of human pregnane X receptor antagonists utilizing a high-throughput screening platform. [PDF]

Front Pharmacol
Pregnane X receptor (PXR) is a xenobiotic-sensing nuclear receptor with a well-established role in regulating drug metabolism and clearance. Recent studies have shown that PXR is involved in cell proliferation, apoptosis, immune response, and energy ...
Lynch C, Margolis R, Niebler J, Travers J, Sakamuru S, Zhao T, Klumpp-Thomas C, Huang R, Xia M.   +8 more
europepmc   +2 more sources

Expanding the Library of 1,2,4-Oxadiazole Derivatives: Discovery of New Farnesoid X Receptor (FXR) Antagonists/Pregnane X Receptor (PXR) Agonists. [PDF]

Molecules, 2023
Compounds featuring a 1,2,4-oxadiazole core have been recently identified as a new chemotype of farnesoid X receptor (FXR) antagonists. With the aim to expand this class of compounds and to understand the building blocks necessary to maintain the ...
Finamore C, Festa C, Fiorillo B, Leva FSD, Roselli R, Marchianò S, Biagioli M, Spinelli L, Fiorucci S, Limongelli V, Zampella A, De Marino S.   +11 more
europepmc   +2 more sources

Activation of pregnane X receptor induces atherogenic lipids and PCSK9 by a SREBP2‐mediated mechanism

British Journal of Pharmacology, 2021
Many drugs and environmental contaminants induce hypercholesterolemia and promote the risk of atherosclerotic cardiovascular disease. We tested the hypothesis that pregnane X receptor (PXR), a xenobiotic‐sensing nuclear receptor, regulates the level of ...
Mikko Karpale, A. Käräjämäki, Outi Kummu, H. Gylling, T. Hyötyläinen, M. Orešič, A. Tolonen, H. Hautajärvi, M. Savolainen, M. Ala-Korpela, J. Hukkanen, J. Hakkola   +11 more
semanticscholar   +1 more source

The Pregnane-X receptor regulates steroid synthesis in mouse Leydig cells. [PDF]

Front Endocrinol (Lausanne)
IntroductionPregnane X Receptor (PXR, NR1I2) is a ligand-dependent transcription factor belonging to the nuclear receptor superfamily, that can be activated by a wide variety of endogenous and exogenous ligands.
Martinot E, Holota H, de Haze A, Beaudoin C, Volle DH.   +4 more
europepmc   +2 more sources

Pregnane X Receptor Is a Target of Farnesoid X Receptor [PDF]

Journal of Biological Chemistry, 2006
The pregnane X receptor (PXR) is an essential component of the body's detoxification system. PXR is activated by a broad spectrum of xenobiotics and endobiotics, including bile acids and their precursors. Bile acids in high concentrations are toxic; therefore, their synthesis is tightly regulated by the farnesoid X receptor, and their catabolism ...
Diana Jung, David J. Mangelsdorf, Urs A. Meyer   +2 more
openaire   +2 more sources