Results 21 to 30 of about 7,232 (124)

Hepatic ZBTB22-mediated detoxification ameliorates acetaminophen-induced liver injury by inhibiting pregnane X receptor signaling

iScience, 2023
Summary: Overdose acetaminophen (APAP) can cause acute liver injury (ALI), but the underlying mechanism remains undetermined. This study explored the role of hepatic Zinc Finger And BTB Domain Containing 22 (ZBTB22) in defense against APAP-mediated ...
Yingjian Chen, Tianqi Cui, Shaorong Xiao, Tianyao Li, Yadi Zhong, Kaijia Tang, Jingyi Guo, Shangyi Huang, Jiabing Chen, Jiayu Li, Qi Wang, Jiawen Huang, Huafeng Pan, Yong Gao   +13 more
doaj   +1 more source

A brief history of the discovery of PXR and CAR as xenobiotic receptors

Acta Pharmaceutica Sinica B, 2016
The nuclear receptors pregnane X receptor (PXR) and constitutive androstane receptor (CAR) were cloned and/or established as xenobiotic receptors in 1998.
Jiong Yan, Wen Xie
doaj   +1 more source

No correlation of hsa-miR-148a with expression of PXR or CYP3A4 in human livers from Chinese Han population. [PDF]

PLoS ONE, 2013
There is a huge variability of hepatic CYP3A4 level in human populations, which was believed to contribute to different responses to drugs among individuals. Transcription of CYP3A4 was regulated by transcription factors such as pregnane X receptor (PXR).
Zhiyun Wei, Mingjie Chen, Yiting Zhang, Xiaofei Wang, Songshan Jiang, Yang Wang, Xi Wu, Shengying Qin, Lin He, Lirong Zhang, Qinghe Xing   +10 more
doaj   +1 more source

Rifampicin does not significantly affect the expression of Small heterodimer partner (SHP) in primary human hepatocytes

Frontiers in Pharmacology, 2012
The small/short heterodimer partner (SHP, NR0B2) is a nuclear receptor corepressor lacking a DNA binding domain. SHP is induced by bile acid-activated farnesoid X receptor (FXR) resulting in CYP7A1 gene suppression. In contrast, Pregnane X receptor (PXR)
Petr ePavek, Lucie eStejskalova, Lucie eKrausova, Michal eBitman, Radim eVrzal, Zdenek eDvorak   +5 more
doaj   +1 more source

Associations between Pregnane X Receptor and Breast Cancer Growth and Progression

Cells, 2020
Pregnane X receptor (PXR, NR1I2) is a member of the ligand-activated nuclear receptor superfamily. This receptor is promiscuous in its activation profile and is responsive to a broad array of both endobiotic and xenobiotic ligands.
Bradley A. Creamer, Shelly N. B. Sloan, Jennifer F. Dennis, Robert Rogers, Sidney Spencer, Andrew McCuen, Purnadeo Persaud, Jeff L. Staudinger   +7 more
doaj   +1 more source

Phallusiasterol C, A New Disulfated Steroid from the Mediterranean Tunicate Phallusia fumigata

Marine Drugs, 2016
A new sulfated sterol, phallusiasterol C (1), has been isolated from the Mediterranean ascidian Phallusia fumigata and its structure has been determined on the basis of extensive spectroscopic (mainly 2D NMR) analysis. The possible role in regulating the
Concetta Imperatore, Maria Senese, Anna Aiello, Paolo Luciano, Stefano Fiorucci, Claudio D’Amore, Adriana Carino, Marialuisa Menna   +7 more
doaj   +1 more source

Myeloid-specific deficiency of pregnane X receptor decreases atherosclerosis in LDL receptor-deficient mice[S]

Journal of Lipid Research, 2020
The pregnane X receptor (PXR) is a nuclear receptor that can be activated by numerous drugs and xenobiotic chemicals. PXR thereby functions as a xenobiotic sensor to coordinately regulate host responses to xenobiotics by transcriptionally regulating many
Yipeng Sui, Zhaojie Meng, Se-Hyung Park, Weiwei Lu, Christopher Livelo, Qi Chen, Tong Zhou, Changcheng Zhou   +7 more
doaj   +1 more source

Phallusiasterols A and B: Two New Sulfated Sterols from the Mediterranean Tunicate Phallusia fumigata and Their Effects as Modulators of the PXR Receptor

Marine Drugs, 2014
Purification of the apolar extracts of the marine ascidian Phallusia fumigata, afforded two new sulfated sterols, phallusiasterols A (1) and B (2). The structures of the new compounds have been elucidated using mass spectrometry and NMR experiments.
Concetta Imperatore, Filomena D'Aniello, Anna Aiello, Stefano Fiorucci, Claudio D'Amore, Valentina Sepe, Marialuisa Menna   +6 more
doaj   +1 more source

Regulation of CAR and PXR Expression in Health and Disease

Cells, 2020
Pregnane X receptor (PXR, NR1I2) and constitutive androstane receptor (CAR, NR1I3) are members of the nuclear receptor superfamily that mainly act as ligand-activated transcription factors. Their functions have long been associated with the regulation of
Martine Daujat-Chavanieu, Sabine Gerbal-Chaloin   +1 more
doaj   +1 more source

Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis

Angewandte Chemie, Volume 138, Issue 25, 15 June 2026.
Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Grace A. Okunlola, Godwin A. Aleku
wiley   +2 more sources