Results 41 to 50 of about 8,350 (160)
Transactivation Assays to Assess Canine and Rodent Pregnane X Receptor (PXR) and Constitutive Androstane Receptor (CAR) Activation. [PDF]
PLoS One, 2016 The pregnane X receptor (PXR/SXR, NR1I2) and constitutive androstane receptor (CAR, NR1I3) are nuclear receptors (NRs) involved in the regulation of many genes including cytochrome P450 enzymes (CYPs) and transporters important in metabolism and uptake ...
Pinne M, Ponce E, Raucy JL.
europepmc +2 more sources
Tumareseptori PXR lihavuudessa ja sen metabolinen säätely
, 2021 The prevalence of metabolic diseases is paralleled by increases in exposure to foreign chemicals, e.g. drugs and environmental contaminants. Rather common for these chemicals is their ability to activate Pregnane X receptor (PXR), a master regulator of ...
Karpale, Mikko
core +1 more source
Animal Research and One Health, EarlyView.Our paper systematically reviews the intestinal structure, function, and microbiota of ostriches, along with strategies for improving their gut health. We analyze how these factors collectively influence intestinal homeostasis and ostrich welfare, emphasizing probiotics as a promising intervention to enhance gut health, boost population well‐being, and
Zi‐Qun Zhang +6 more
wiley +1 more source
Journal of Applied Toxicology, EarlyView.ABSTRACT Diisononyl phthalate (DINP) is a high molecular weight phthalate and high production volume chemical. DINP's carcinogenic potential has been investigated in four rodent bioassays, with liver tumors observed in three of the studies. Authoritative assessments have hypothesized that DINP acts through the peroxisome proliferator‐activated receptor
Amanda N. Buerger +3 more
wiley +1 more source
Adverse outcome pathway for pregnane X receptor-induced hypercholesterolemia [PDF]
, 2023 Pharmaceuticals and environmental contaminants contribute to hypercholesterolemia. Several chemicals known to cause hypercholesterolemia, activate pregnane X receptor (PXR).
Itkonen, Anna +5 more
core +1 more source
Nuclear Receptor PXR in Drug-Induced Hypercholesterolemia
Cells, 2022 Atherosclerosis is a major global health concern. The central modifiable risk factors and causative agents of the disease are high total and low-density lipoprotein (LDL) cholesterol.
Mikko Karpale +2 more
doaj +1 more source
Current Cell/Organoid and Animal Models for Primary Sclerosing Cholangitis
Portal Hypertension &Cirrhosis, EarlyView.Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease with limited therapeutic options and a marked risk of progression to biliary fibrosis, cirrhosis, and malignancy. Progress in PSC research has been hindered by the lack of models that faithfully recapitulate the complex biliary microenvironment and disease heterogeneity ...
Qigu Yao +4 more
wiley +1 more source
Expressão dos genes Receptor Pregnano X (PXR), Citocromo P4503A (CYP3A) e resistência a multidrogas 1(MDR1) em fígado de peixe-zebra (Danio rerio) [PDF]
, 2005 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Biotecnologia.O receptor pregnano X (PXR) é um receptor nuclear envolvido na regulação transcricional de enzimas envolvidas no ...
Bresolin, Taise
core
Responsive Materials, EarlyView.An oxygen‐responsive living bioreactor was engineered via interspecies protoplast fusion, converting oxygen from an inhibitory stress into a programmable signal for sustained indole‐3‐propionic acid (IPA) production. This genetically encoded bioreactor enables robust aerobic operation and therapeutic efficacy of deoxynivalenol detoxification in vivo ...
Ning Ma +8 more
wiley +1 more source
Post-translational Modification of Pregnane X Receptor [PDF]
, 2011 Pregnane x receptor (PXR, NR1I2) was originally characterized as a broad spectrum entero-hepatic xenobiotic ‘sensor’ and master-regulator of drug inducible gene expression.
Jeff L. Staudinger +7 more
core +1 more source