Results 41 to 50 of about 6,716 (130)

Allosteric Antagonism of the Pregnane X Receptor (PXR): Current-State-of-the-Art and Prediction of Novel Allosteric Sites. [PDF]

Cells, 2022
Kamaraj R, Drastik M, Maixnerova J, Pavek P.   +3 more
europepmc   +1 more source

Expanding the Library of 1,2,4-Oxadiazole Derivatives: Discovery of New Farnesoid X Receptor (FXR) Antagonists/Pregnane X Receptor (PXR) Agonists. [PDF]

Molecules, 2023
Finamore C, Festa C, Fiorillo B, Leva FSD, Roselli R, Marchianò S, Biagioli M, Spinelli L, Fiorucci S, Limongelli V, Zampella A, De Marino S.   +11 more
europepmc   +1 more source

Non-genomic effects of the Pregnane X Receptor (PXR) and Retinoid X Receptor (RXR) in platelets [PDF]

, 2018
Background: The pregnane X receptor (PXR) is a nuclear receptor (NR) involved in the detoxification of xenobiotic compounds via upregulation of cytochrome P450 enzyme expression. Recently, the presence of PXR was reported in the human vasculature and its ligands were proposed to exhibit anti-atherosclerotic effects.
openaire   +1 more source

Discrepancy in interactions and conformational dynamics of pregnane X receptor (PXR) bound to an agonist and a novel competitive antagonist. [PDF]

Comput Struct Biotechnol J, 2022
Rashidian A, Mustonen EK, Kronenberger T, Schwab M, Burk O, Laufer SA, Pantsar T.   +6 more
europepmc   +1 more source

Environmental contaminants activate human and polar bear (Ursus maritimus) pregnane X receptors (PXR, NR1I2) differently

Toxicology and Applied Pharmacology, 2015
Many persistent organic pollutants (POPs) accumulate readily in polar bears because of their position as apex predators in Arctic food webs. The pregnane X receptor (PXR, formally NR1I2, here proposed to be named promiscuous xenobiotic receptor) is a xenobiotic sensor that is directly involved in metabolizing pathways of a wide range of environmental ...
Lille-Langøy, Roger, Goldstone, Jared V., Rusten, Marte, Milnes, Matthew R., Male, Rune, Stegeman, John J., Blumberg, Bruce, Goksøyr, Anders   +7 more
openaire   +5 more sources

Identification of novel pregnane X receptor (PXR) agonists by In silico and biological activity analyses and reversal of cigarette smoke-induced PXR downregulation. [PDF]

Biochem Biophys Res Commun, 2021
Reddy RT, Nyunoya T.
europepmc   +1 more source

Pregnane X receptor (PXR) [PDF]

Science-Business eXchange, 2011
openaire   +1 more source

CRISPR-Cas9-Mutated Pregnane X Receptor (pxr) Retains Pregnenolone-induced Expression of cyp3a65 in Zebrafish (Danio rerio) Larvae. [PDF]

Toxicol Sci, 2020
Salanga MC, Brun NR, Francolini RD, Stegeman JJ, Goldstone JV.   +4 more
europepmc   +1 more source

The 3'-untranslated region contributes to the pregnane X receptor (PXR) expression down-regulation by PXR ligands and up-regulation by glucocorticoids. [PDF]

Acta Pharm Sin B, 2020
Smutny T, Dusek J, Hyrsova L, Nekvindova J, Horvatova A, Micuda S, Gerbal-Chaloin S, Pavek P.   +7 more
europepmc   +1 more source

A novel germline Pregnane X Receptor (PXR) variant predisposing to Hodgkin lymphoma in two siblings

European Journal of Medical Genetics
Hodgkin's lymphoma (HL) is the most common cancer in adolescents and young adults. A family history of HL increases the risk of developing HL in other family members. Identification of genetic predisposition variants in HL is important for understanding disease aetiology, prognosis, and response to treatment. Aberrant activation of the NF-κB pathway is
Khodzhaev, Khusan, Sudutan, Tuğce, Erbilgin, Yücel, Sarıtaş, Merve, Yeğen, Gülçin, Bozkurt, Ceyhun, Sayitoğlu, Müge, Kebudi, Rejin   +7 more
openaire   +2 more sources