Results 211 to 220 of about 30,346 (255)

Pregnenolone derivatives as potential anticancer agents.

Steroids, 2011
Pregnenolone (1) was used as a template to develop new anticancer compounds. Ring-D modification of 1 resulted in the synthesis of benzylidenes 2-17, pyrazolines 18-76, pyrazoles 85-91, hydrazones 77-84, and oximes 92-107 derivatives. The structure of compound 107 was also deduced through single crystal X-ray diffraction studies.
M. Choudhary, M. Alam, Atta-ur-rahman, S. Yousuf, Y. Wu, A. Lin, Farhana Shaheen   +6 more
semanticscholar   +3 more sources

Pregnenolone sulfate: a positive allosteric modulator at the N-methyl-D-aspartate receptor.

Molecular Pharmacology, 1991
The N-methyl-D-aspartate (NMDA) receptor is believed to play a major role in learning and in excitotoxic neuronal damage associated with stroke and epilepsy.
Fong-Sen Wu, T. T. Gibbs, D. Farb
semanticscholar   +1 more source

Pregnenolone sulfate antagonizes barbiturate-induced hypnosis

Pharmacology Biochemistry and Behavior, 1989
The potential influence of the neurosteroid pregnenolone sulfate (PrS) on barbiturate-induced hypnosis was tested in rats. PrS, when injected intracerebroventricularly or intraperitoneally, significantly shortened the sleep-time produced by pentobarbital.
M D, Majewska, M T, Bluet-Pajot, P, Robel, E E, Baulieu   +3 more
openaire   +2 more sources

Dehydroepiandrosterone and Pregnenolone

1999
Steroid hormones play a multifactorial role in human physiology. They facilitate coordinative processes that enable neural, endocrine, immune, and metabolic systems, separately or collectively, to operate in solving problems of survival and reproduction.
Rakhmawati Sih, Hosam Kamel, Mohamad Horani, John E. Morley   +3 more
openaire   +1 more source

Pregnenolone and pregnenolone sulfate, alone and with ethanol, in mice on the plus-maze

Pharmacology Biochemistry and Behavior, 1994
The neurosteroids pregnenolone and pregnenolone sulfate were tested for anxiogenic/anxiolytic effects in mice on the elevated plus-maze. Pregnenolone in a dose of 0.01 micrograms/kg increased motor activity and caused an anxiogenic response, i.e., a decreased number of entries onto the open arms of the plus-maze.
C L, Melchior, R F, Ritzmann
openaire   +2 more sources

Urinary marker of oral pregnenolone administration

Steroids, 2005
Pregnenolone (PREG) can potentially be abused by athletes to maintain an equilibration of the steroidal environment after sex steroids administrations. Five men volunteers orally ingested 50 mg PREG to determine optimal urinary markers for detection of this steroid. Our findings show that ingestion of PREG has no significant effects on the testosterone/
Christophe, Saudan, Aurélien, Desmarchelier, Pierre-Edouard, Sottas, Patrice, Mangin, Martial, Saugy   +4 more
openaire   +2 more sources

METABOLISM OF PREGNENOLONE AND PREGNENOLONE SULPHATE IN HUMAN FOETAL LIVER TISSUE IN VITRO

Acta Endocrinologica, 1974
ABSTRACT The metabolism of pregnenolone and pregnenolone sulphate was studied in incubations with minced foetal liver tissue. In most of the incubations, non-radioactive substrates were used, and the identification and quantitative determination of the metabolites formed was carried out by gasliquid chromatography and gas chromatography – mass ...
openaire   +2 more sources

PREGNENOLONE

The Journal of Clinical Endocrinology & Metabolism, 1950
E, HENDERSON, M, WEINBERG, W A, WRIGHT
openaire   +2 more sources

Polymorphism of Pregnenolone Acetate

Science, 1951
D H, GOULD, W, TARPLEY
openaire   +2 more sources

Adjunctive Pregnenolone Ameliorates the Cognitive Deficits in Recent-Onset Schizophrenia: An 8-Week, Randomized, Double-Blind, Placebo-Controlled Trial.

Clinical Schizophrenia and Related Psychoses, 2017
A. Kreinin, Nisham Bawakny, M. Ritsner
semanticscholar   +1 more source