Results 121 to 130 of about 2,389 (154)
Some of the next articles are maybe not open access.
Preimplantation genetic diagnosis
Nature Reviews Genetics, 2002Preimplantation genetic diagnosis (PGD) is an evolving technique that provides a practical alternative to prenatal diagnosis and termination of pregnancy for couples who are at substantial risk of transmitting a serious genetic disorder to their offspring.
Braude, P +3 more
openaire +5 more sources
Preimplantation testing for phenylketonuria
Fertility and Sterility, 2001To use preimplantation genetic diagnosis to achieve a phenylketonuria-free pregnancy in a couple at 50% risk for producing an affected child.DNA analysis of the first and second polar bodies (PB1 and PB2) obtained from oocytes of a heterozygous mother in IVF-ET, with the goal of identifying and transferring back to the patient the embryos resulting ...
Y, Verlinsky +4 more
openaire +2 more sources
Preimplantation genetic testing
BMJ, 2012#### Summary points Preimplantation genetic (PG) testing is the practice of obtaining a cellular biopsy sample from a developing human oocyte or embryo, acquired via a cycle of in vitro fertilisation (IVF); evaluating the genetic composition of this sample; and using this information to determine which embryos will be optimal for subsequent uterine ...
Paul R, Brezina +2 more
openaire +2 more sources
PREIMPLANTATION PRENATAL DIAGNOSIS
Obstetrics and Gynecology Clinics of North America, 1993Preimplantation prenatal diagnosis refers to the application of molecular genetic techniques to the assessment of gametes before conception or to early embryos before implantation. Such techniques could allow couples at significant risk for a variety of known genetic diseases to use assisted reproductive technology in achieving pregnancies that are ...
openaire +2 more sources
Preimplantation Genetic Screening
2013Chromosome aneuploidy is naturally occurring, typically sporadic and generally leads to non-viable offspring. The use of PGS has the potential to select the best embryos for transfer and reduce the risk of losing a much wanted pregnancy. However there is no high-level clinical evidence from randomized control trials to demonstrate a beneficial effect ...
Repping, Sjoerd +2 more
openaire +1 more source
Survival Signalling in the Preimplantation Embryo
Theriogenology, 2012The development of the preimplantation embryo (from fertilisation until the formation of the differentiated blastocyst) occurs without a requirement for exogenous mitogenic or survival signals. This distinguishes the behaviour of cells in the early embryo from all other normal cells.
C, O'Neill, Y, Li, X L, Jin
openaire +3 more sources
FISH in Preimplantation Diagnosis
2003Analysis of chromosomes in human embryonic nuclei would ideally be achieved by karyotyping. Several studies have used this technique to examine human embryonic chromosomes (1-4), but information is limited, since it is difficult to obtain bandable metaphase spreads.
J C, Harper, J D, Delhanty
openaire +2 more sources
Preimplantation genetic diagnosis
Current Opinion in Pediatrics, 1994Preimplantation genetic diagnosis now represents an alternative reproductive option for parents at high risk of having offspring affected with certain genetic diseases. Progress in the past year has included increasing reliability in embryo sexing by both polymerase chain reaction and fluorescent in situ hybridization techniques; delivery of babies ...
openaire +2 more sources
[Preimplantation genetic diagnosis].
Ugeskrift for laeger, 2018In Denmark, preimplantation genetic diagnosis (PGD) is offered within the public healthcare to families with a known risk of an inherited disease in a child - as an alternative to prenatal diagnosis. It is a well-established technique with rather well-described perinatal- and neonatal outcomes, being comparable to what is seen following in vitro ...
Ingerslev, Hans Jakob +7 more
openaire +2 more sources
Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz, 2015
Preimplantation diagnosis (PID) comprises all the relevant diagnostic procedures for the investigation of genetic, structural, or numerical changes of the genetic information in spermatozoa and oocytes as well as in embryos after in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI).
M, Montag, B, Toth, T, Strowitzki
openaire +1 more source
Preimplantation diagnosis (PID) comprises all the relevant diagnostic procedures for the investigation of genetic, structural, or numerical changes of the genetic information in spermatozoa and oocytes as well as in embryos after in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI).
M, Montag, B, Toth, T, Strowitzki
openaire +1 more source