Results 21 to 30 of about 449,800 (228)

Preimplantation Genetic Testing for Genetic Diseases: Limits and Review of Current Literature

Genes, 2023
Preimplantation genetic testing (PGT) has emerged as a revolutionary technique in the field of reproductive medicine, allowing for the selection and transfer of healthy embryos, thus reducing the risk of transmitting genetic diseases.
Roberta Giuliano, Anna Maione, Angela Vallefuoco, Ugo Sorrentino, Daniela Zuccarello   +4 more
semanticscholar   +1 more source

Pre-implantation Genetic Testing for Aneuploidy (PGT-A)

Thai Journal of Obstetrics and Gynaecology, 2020
Preimplantation genetic diagnosis (PGD) or embryo selection was first performed in 1989 using PCR for gender selection to avoid X-linked recessive disorder. However, there was a misdiagnosis due to allele drop out (ADO). Therefore, fluorescent in situ
Wirawit Piyamongkol
doaj   +1 more source

Targeting myotonic dystrophy by preimplantation genetic diagnosis-karyomapping

Taiwanese Journal of Obstetrics & Gynecology, 2019
Objective: To report a case with Myotonic dystrophy type I with successful preimplantation genetic diagnosis-karyomapping. Case report: A 34-year-old female carrier of myotonic dystrophy type I was treated at our clinic with a successful pregnancy after ...
Cheng-Wei Wang, Yung-Liang Liu, Chi-Huang Chen   +2 more
doaj   +1 more source

Evolution and utility of preimplantation genetic testing for monogenic disorders in assisted reproduction - A narrative review

Journal of Human Reproductive Sciences, 2021
Preimplantation genetic testing (PGT) for monogenic disorders and assisted reproductive technology have evolved and progressed in tandem. PGT started with single-cell polymerase chain reaction (PCR) followed by fluorescent in situ hybridisation for a ...
Firuza R Parikh, Arundhati S Athalye, Dhananjaya K Kulkarni, Rupesh R Sanap, Suresh B Dhumal, Dhanashree J Warang, Dattatray J Naik, Prochi F Madon   +7 more
doaj   +1 more source

A systematic review and meta-analysis: clinical outcomes of recurrent pregnancy failure resulting from preimplantation genetic testing for aneuploidy

Frontiers in Endocrinology, 2023
Background Preimplantation genetic testing for aneuploidy (PGT-A) is an emerging technology that aims to identify euploid embryos for transfer, reducing the risk of embryonic chromosomal abnormalities. However, the clinical benefits of PGT-A in recurrent
Zhu Liang, Q. Wen, Jingjing Li, D. Zeng, Pinxiu Huang   +4 more
semanticscholar   +1 more source

De novo balanced reciprocal translocation mosaic t(1;3)(q42;q25) detected by prenatal genetic diagnosis: a fetus conceived using preimplantation genetic testing due to a t(12;14)(q22;q13) balanced paternal reciprocal translocation

Molecular Cytogenetics, 2021
Introduction De novo balanced reciprocal translocations mosaicism in fetus conceived using preimplantation genetic testing from a different balanced translocation carrier parent has been rarely reported. Methods Chromosomal microarray analysis, karyotype
Shaoqin Zhang, Jianjiang Zhu, Hong Qi, Limei Xu, Lirong Cai, Ran Meng   +5 more
doaj   +1 more source

Genetic counseling for pre-implantation genetic testing of monogenic disorders (PGT-M)

Frontiers in Reproductive Health, 2023
Pre-implantation genetic testing (PGT) is a vital tool in preventing chromosomal aneuploidies and other genetic disorders including those that are monogenic in origin. It is performed on embryos created by intracytoplasmic sperm injection (ICSI). Genetic
Firuza Parikh, Arundhati Athalye, Prochi Madon, Meenal Khandeparkar, Dattatray Naik, Rupesh Sanap, Anuradha Udumudi   +6 more
doaj   +1 more source

Analysis of euploidy rates in preimplantation genetic testing for aneuploidy cycles with progestin-primed versus GnRH agonist/antagonist protocol

European Journal of Medical Research, 2023
Background Progestins can suppress endogenous luteinising hormone (LH) secretion from the pituitary gland and have shown similar efficacy in terms of collecting competent oocytes and embryos; however, some inconsistencies have been proposed regarding the
Lu Wang, Jingyun Wang, Yuan Zhang, C. Qian, Xiaohui Wang, Jie Bai, Fang Li, Zhiqin Chen, A. Ai   +8 more
semanticscholar   +1 more source

Preimplantation genetic testing and child health: a national register-based study

Human Reproduction, 2023
STUDY QUESTION Is preimplantation genetic testing (PGT) associated with adverse perinatal outcome and early childhood health? SUMMARY ANSWER Children born after PGT had comparable perinatal outcomes to children born after IVF/ICSI and comparable findings
E. Ginström Ernstad, C. Hanson, K. Wånggren, A. Thurin‐Kjellberg, Cecilia Hulthe Söderberg, E. Syk Lundberg, M. Petzold, U. Wennerholm, C. Bergh   +8 more
semanticscholar   +1 more source

Past, Present, and Future Strategies for Enhanced Assessment of Embryo's Genome and Reproductive Competence in Women of Advanced Reproductive Age

Frontiers in Endocrinology, 2019
Recent advancements in genomic analysis allow testing of an increasing number of genetic features in human preimplantation embryos. Typical single gene mutation and whole chromosomes testing can now be integrated with assessment of mitochondrial DNA and ...
Maurizio Poli, Maurizio Poli, Laura Girardi, Marco Fabiani, Martina Moretto, Valeria Romanelli, Cristina Patassini, Daniela Zuccarello, Antonio Capalbo, Antonio Capalbo, Antonio Capalbo   +10 more
doaj   +1 more source