Results 11 to 20 of about 3,344 (173)

Noninvasive preimplantation genetic testing for aneuploidy using blastocyst spent culture medium may serve as a backup of trophectoderm biopsy in conventional preimplantation genetic testing [PDF]

BMC Medical Genomics
Background To investigate whether the noninvasive preimplantation genetic testing (niPGT) complement conventional preimplantation genetic testing (PGT) in the embryos for aneuploidy.
Songchang Chen, Li Wang, Yuting Hu, Yaxin Yao, Fangfang Gao, Chunxin Chang, Lanlan Zhang, Hefeng Huang, Daru Lu, Chenming Xu   +9 more
doaj   +2 more sources

Non-invasive preimplantation genetic testing for aneuploidies: an update [PDF]

Reproductive BioMedicine Online, 2022
Aneuploidy is common among preimplantation human embryos used in assisted reproductive technology. Because abnormal chromosome number can negatively affect reproductive outcome, in-vitro-fertilized embryos routinely undergo aneuploidy testing before transfer into the uterus.
Luis Navarro-Sánchez, Carmen García-Pascual, Carmen Rubio, Carlos Simón   +3 more
openaire   +5 more sources

Efficacy of non-invasive chromosome screening, preimplantation genetic testing for aneuploidy, and morphological grading in selecting embryos of patients with advanced maternal age: a three-armed prospective cohort study [PDF]

BMC Pregnancy and Childbirth
Background Non-invasive chromosome screening (NICS) and trophectoderm biopsy preimplantation genetic testing for aneuploidy (TE-PGT) were both applied for embryo ploidy detection, However, the cumulative live birth rates (CLBR) of NICS and TE-PGT in ...
Qin Sun, Juanjuan Xu, Yaxin Yao, Xuan Huang, Dunmei Zhao, Sijia Lu, Bing Yao, Li Chen   +7 more
doaj   +2 more sources

Navigating Non-invasive Preimplantation Genetic Testing for Aneuploidy (niPGT-A) – Technical Challenges and Ethical Considerations [PDF]

Journal of Human Reproductive Sciences
Alexis Heng Boon Chin, Ningyu Sun
doaj   +2 more sources

Embryo ploidy status classification through computer-assisted morphology assessmentAJOG MFM at a Glance

AJOG Global Reports, 2023
BACKGROUND: Preimplantation genetic testing for aneuploidy has been proven to be effective in determining the embryo's chromosomal or ploidy status. The test requires a biopsy of embryonic cells on day 3, 5, or 6 from which complete information on the ...
Gunawan Bondan Danardono, SKom, BEng, Nining Handayani, DVM, MBiomed, Claudio Michael Louis, SKom, BEng, Arie Adrianus Polim, MD, SpOG, DMAS, MBHRE, Batara Sirait, SpOG, Gusti Periastiningrum, SSi, Szeifoul Afadlal, PhD, Arief Boediono, DVM, Ivan Sini, MD, FRANZOG, GDRM, MMIS, SpOG   +8 more
doaj   +1 more source

A comprehensive preimplantation genetic testing approach for SEA-type α-thalassemia by fluorescent gap-polymerase chain reaction combined with haplotype analysis

Frontiers in Genetics, 2023
Introduction: This study aimed to evaluate the feasibility and necessity of using fluorescence Gap-polymerase chain reaction combined with haplotype analysis in preimplantation genetic testing for SEA-type α-thalassemia.Methods: A total of 26 ...
Jing Wang, Yuanlin Ma, Jing Guo, Rong Li, Canquan Zhou, Yanwen Xu   +5 more
doaj   +1 more source

Noninvasive preimplantation genetic testing for aneuploidy

Bulletin of Russian State Medical University, 2023
To date the world community is actively working to optimize the approaches to determining chromosomal abnormalities in embryos. The study was aimed to assess the possibility of using noninvasive preimplantation genetic testing for aneuploidy (niPGT-A) through analysis of cell-free DNA in spent culture medium (SCM).
OI Lisitsyna, AN Ekimov, EE Atapina, AG Syrkasheva, EG Goryainova, NP Makarova, DYu Trofimov, NV Dolgushina   +7 more
openaire   +1 more source

Implementation of Noninvasive Preimplantation Genetic Testing for Aneuploidy with Spent Blastocyst Medium into Clinical and Laboratory Practice: The First Successful Experience in Taiwan

Fertility & Reproduction, 2023
Noninvasive preimplantation genetic testing for aneuploidy (niPGT-A) using cell-free DNA (cfDNA) present in the spent blastocyst medium (SBM) of human blastocysts has emerged as an alternative for classical preimplantation genetic testing for aneuploidy (
Chun-Kai Chen, Wei-Han Huang, Tiencheng Arthur Chang, Kuang-Han Chao, Wang-Fung Chiang, Hsin-Yi Yeh, Szu-Yu Shen   +6 more
doaj   +1 more source

Application of machine learning to predict aneuploidy and mosaicism in embryos from in vitro fertilization cyclesAJOG Global Reports at a Glance

AJOG Global Reports, 2022
BACKGROUND: The factors associated with embryo aneuploidy have been extensively studied. Mostly maternal age and to a lesser extent male factor and ovarian stimulation have been related to the occurrence of chromosomal alterations in the embryo.
José A. Ortiz, PhD, Ruth Morales, PhD, Belén Lledó, PhD, Juan A. Vicente, PhD, Julio González, PhD, Eva M. García-Hernández, PhD, Alba Cascales, MSc, Jorge Ten, PhD, Andrea Bernabeu, PhD, MD, Rafael Bernabeu, PhD, MD   +9 more
doaj   +1 more source

Pre-implantation Genetic Testing for Aneuploidy (PGT-A)

Thai Journal of Obstetrics and Gynaecology, 2020
Preimplantation genetic diagnosis (PGD) or embryo selection was first performed in 1989 using PCR for gender selection to avoid X-linked recessive disorder. However, there was a misdiagnosis due to allele drop out (ADO). Therefore, fluorescent in situ
Wirawit Piyamongkol
doaj   +1 more source