Results 31 to 40 of about 3,344 (173)

A systematic review of noninvasive preimplantation genetic testing for aneuploidy

Fertility and Sterility, 2023
Noninvasive and minimally invasive preimplantation genetic testing for aneuploidy (PGT-A) is a tool that may one day become the gold standard for embryonic chromosomal screening. Investigations on this topic have ranged from studying the culture media of embryos to the fluid inside the blastocoel, all in an attempt to find a reliable source of DNA ...
Cengiz, Cinnioglu, Heather, Glessner, Amy, Jordan, Sydney, Bunshaft   +3 more
openaire   +2 more sources

Comparison of aneuploidy rates between conventional in vitro fertilization and intracytoplasmic sperm injection in in vitro fertilization–intracytoplasmic sperm injection split insemination cycles

F&S Reports, 2020
Objective: To evaluate the influence of insemination methods on outcomes of preimplantation genetic testing for aneuploidy (PGT-A) by assessing PGT-A results in embryos that derived from conventional in vitro fertilization (IVF) versus intracytoplasmic ...
Jie Deng, M.D., Ph.D., Olutunmike Kuyoro, M.D., Qianying Zhao, M.S., Barry Behr, Ph.D., Ruth B. Lathi, M.D.   +4 more
doaj   +1 more source

Comparison of chromosomal status in reserved multiple displacement amplification products of embryos that resulted in miscarriages or live births: a blinded, nonselection case–control study

BMC Medical Genomics, 2022
Objective To analyze chromosomal status in reserved multiple displacement amplification (MDA) products of embryos that result in miscarriages or live births.
Guoxia Yang, Yan Xu, Yanhong Zeng, Jing Guo, Jiafu Pan, Canquan Zhou, Yanwen Xu   +6 more
doaj   +1 more source

Previously reported and here added cases demonstrate euploid pregnancies followed by PGT-A as “mosaic” as well as “aneuploid” designated embryos

Reproductive Biology and Endocrinology, 2023
Background After the longest time opposing all transfers of embryos by preimplantation genetic testing for aneuploidy (PGT-A) diagnosed as “chromosomal-abnormal,” the field has over recent years slowly been moving toward selective transfers of by PGT-A ...
Norbert Gleicher, Pasquale Patrizio, Lyka Mochizuki, David H. Barad   +3 more
doaj   +1 more source

Healthy live births after mosaic blastocyst transfers with the use of next-generation sequencing

Taiwanese Journal of Obstetrics & Gynecology, 2019
Objective: To determine whether transfer of high-mosaicism (≥50%) embryos can result in healthy newborns. Case report: Two embryos resulting from controlled ovarian stimulation (COS) in Patient one, 41 years of age (y/o), underwent preimplantation ...
Yung-Liang Liu, Tzu-Ning Yu, Ching-Hui Chen, Peng-Hui Wang, Chi-Huang Chen, Chii-Ruey Tzeng   +5 more
doaj   +1 more source

The inconsistency between two major aneuploidy-screening platforms—single-nucleotide polymorphism array and next-generation sequencing—in the detection of embryo mosaicism

BMC Genomics, 2022
Background In preimplantation genetic testing for aneuploidy (PGT-A), appropriate evaluation of mosaic embryos is important because of the adverse implications of transferring embryos with high-level mosaicism or discarding those with low-level mosaicism.
Dongjia Chen, Yan Xu, Chenhui Ding, Yali Wang, Yu Fu, Bing Cai, Jing Wang, Rong Li, Jing Guo, Jiafu Pan, Yanhong Zeng, Yiping Zhong, Xiaoting Shen, Canquan Zhou   +13 more
doaj   +1 more source

Performance of preimplantation genetic testing for aneuploidy in IVF cycles for patients with advanced maternal age, repeat implantation failure, and idiopathic recurrent miscarriage

Taiwanese Journal of Obstetrics & Gynecology, 2019
Objective: The primary objective of this study was to investigate whether preimplantation genetic testing for aneuploidy (PGT-A) of blastocysts through array comparative genomic hybridization (aCGH) improves live birth rates (LBR) in IVF cycles for ...
Chun-I. Lee, Cheng-Hsuan Wu, Yi-Ping Pai, Yu-Jun Chang, Chung-I. Chen, Tsung-Hsien Lee, Maw-Sheng Lee   +6 more
doaj   +1 more source

Cell-free DNA in spent culture medium effectively reflects the chromosomal status of embryos following culturing beyond implantation compared to trophectoderm biopsy.

PLoS ONE, 2021
This prospective study evaluated the accuracy of non-invasive preimplantation genetic testing for aneuploidy (niPGT-A) using cell-free DNA in spent culture medium, as well as that of preimplantation genetic testing for aneuploidy (PGT-A) using ...
Akihiro Shitara, Kazumasa Takahashi, Mayumi Goto, Harunori Takahashi, Takuya Iwasawa, Yohei Onodera, Kenichi Makino, Hiroshi Miura, Hiromitsu Shirasawa, Wataru Sato, Yukiyo Kumazawa, Yukihiro Terada   +11 more
doaj   +1 more source

Evaluation of a novel non-invasive preimplantation genetic screening approach. [PDF]

PLoS ONE, 2018
OBJECTIVE:To assess whether embryonic DNA isolated from blastocyst culture conditioned medium (BCCM) combined with blastocoel fluid (BF) could be used for blastocyst stage non-invasive preimplantation genetic testing for chromosomal aneuploidy (non ...
Valeriy Kuznyetsov, Svetlana Madjunkova, Ran Antes, Rina Abramov, Gelareh Motamedi, Zenon Ibarrientos, Clifford Librach   +6 more
doaj   +1 more source

Does ICSI for in vitro fertilization cause more aneuploid embryos?

Molecular Cytogenetics, 2020
Background High proportion of human embryos produced by in vitro fertilization (IVF) is aneuploidy. Many factors are related to the prevalence of embryonic aneuploidies, such as maternal age, sperm quality, and in vitro manipulation of oocytes.
Xiangli Niu, Jiamin Long, Fangqiang Gong, Weihua Wang   +3 more
doaj   +1 more source