Results 51 to 60 of about 3,344 (173)

High concordance between next-generation sequencing and single-nucleotide polymorphism array in preimplantation genetic testing for aneuploidy

Clinical and Experimental Obstetrics & Gynecology, 2022
Background: This study aimed to compare the use of next-generation sequencing (NGS) and single-nucleotide polymorphism (SNP) array in preimplantation genetic testing for aneuploidy (PGT-A) in the same blastocyst.
Zhanhui Ou, Zhiheng Chen, Yu Deng, Ling Sun   +3 more
doaj   +1 more source

We have reached a dead end for preimplantation genetic testing for aneuploidy

Human Reproduction, 2022
Abstract The hypothesis of preimplantation genetic testing for aneuploidy (PGT-A) was first proposed 20 years ago, suggesting that during IVF elimination of aneuploid embryos prior to transfer will improve implantation rates of remaining embryos and, therefore, increase pregnancy and live birth rates, while also reducing miscarriages ...
Norbert Gleicher, David H Barad, Pasquale Patrizio, Raoul Orvieto   +3 more
openaire   +2 more sources

Experiences of Dutch parents undergoing prenatal genomic testing for fetal structural anomalies: A prospective qualitative analysis

Journal of Genetic Counseling, Volume 35, Issue 2, April 2026.
Abstract Prenatal Exome Sequencing (pES) increases the diagnostic rate for genetic disorders in pregnancies with structural abnormalities and substantially impacts parental decision‐making regarding pregnancy continuation or termination. Previous qualitative research on parental experiences of pES has typically been performed several months after ...
Maayke A. de Koning, Sarah Long, Holly E. Evans, Lauren Kelada, Gijs W. E. Santen, Tony Roscioli, Manon Suerink   +6 more
wiley   +1 more source

Addition of Multi‐Level Technologies to Evaluate Eggs and Embryos and Improve Endometrial Quality Applied for In Vitro Fertilization to Achieve Pregnancy: A Case Study

Clinical Case Reports, Volume 14, Issue 3, March 2026.
This integrated clinical approach optimizes the reproductive cycle in several steps, starting with nutrition (A): restricting carbohydrates and inducing ketosis to reduce inflammation and improve insulin sensitivity, which benefits follicular development.
Tania G. Rojas‐Pérez, Yúvika Reyes‐Albarracín, Ginna Ortiz, Juan José Suárez, Diego Vilchis Reyes, Jacqueline Cordero Oropeza, Dinorah Hernández‐Melchor, Esther López‐Bayghen   +7 more
wiley   +1 more source

Deciphering mRNA Translation During Sperm Capacitation: A New Frontier in Fertility Research

Molecular Reproduction and Development, Volume 93, Issue 2, February 2026.
ABSTRACT Male infertility accounts for approximately 50% of infertility cases, with nearly 30% remaining unexplained after standard evaluations. This highlights the need for a better understanding of sperm function to advance diagnostic and therapeutic strategies. Sperm were long considered translationally quiescent; however, emerging evidence suggests
Saurabh Tiwari, Nehal Thakor, Jacob Thundathil   +2 more
wiley   +1 more source

#291 : Association of Maternal Age with Embryonic Aneuploidy and Morphological Score Among Good-Prognosis Infertile Women: A Secondary Analysis of Multicenter, Randomized Controlled Trial

Fertility & Reproduction, 2023
Background and Aims: Maternal age has been reported to impact on embryo genetic status. However, current data on the association between maternal age and early embryo development are limited and inconclusive, especially among good-prognosis women.
Yumei Huang, Wei Zhou, Qian Zhang, Tianxiang Ni, Junhao Yan   +4 more
doaj   +1 more source

Optimisation of Laser‐Assisted Biopsy Parameters in Bovine Embryos

Reproduction in Domestic Animals, Volume 61, Issue 2, February 2026.
ABSTRACT Although laser‐assisted biopsy has shown advantages in other species, optimised protocols for bovine embryos remain scarce. This study developed a systematically optimised laser biopsy method for bovine embryos, which demonstrated high post‐biopsy survival rates. Key parameters including laser energy, needle diameter, and operating medium were
Jingyu Zhang, Hang Shen, Zhenni Zhang, Jianhui Tian, Lei An, Yinjuan Wang   +5 more
wiley   +1 more source

Application of microdeletion and microduplication screening in preimplantation genetic testing: a case report

Journal of Medical Case Reports
Background Microdeletions and microduplications are chromosomal variants ranging up to 3 Mb in size. These abnormalities often arise spontaneously and have significant clinical implications, including developmental delay and congenital anomalies.
Maria Katz, Ben Podgursky, Shenglai Li, Qinnan Zhang, Daniel Shapiro, Monica Pasternak, Noor Siddiqui, Funda Suer, Yuntao Xia   +8 more
doaj   +1 more source

Incidence, Clinical Risk Factors, and Pregnancy Outcomes of Trophectoderm‐ and Inner Cell Mass–Poor‐Quality Blastocysts in Single Blastocyst Transfer Cycles: A Retrospective Cohort Study

Reproductive Medicine and Biology, Volume 25, Issue 1, January/December 2026.
ABSTRACT Purpose To study incidence, clinical risk factors, and pregnancy outcomes of trophectoderm‐ and inner cell mass–poor‐quality blastocysts in single blastocyst transfer cycles. Design A retrospective cohort study included patients who underwent their first single blastocyst transfer cycle.
Longbin Chen, Yangqin Peng, Shuoping Zhang, Yifan Gu, Fei Gong, Ge Lin, Lizhi Leng   +6 more
wiley   +1 more source

Perceptions, motivations and decision regret surrounding preimplantation genetic testing for aneuploidy

Human Reproduction, 2020
Abstract STUDY QUESTION Is there a difference in level of decision regret following IVF treatment between those who choose to complete or not complete preimplantation genetic testing for aneuploidy [PGT-A]?
Amy, Kaing, Mitchell P, Rosen, Molly M, Quinn   +2 more
openaire   +2 more sources