Results 1 to 10 of about 94,951 (305)

Mutations Involved in Premature-Ageing Syndromes [PDF]

The Application of Clinical Genetics, 2021
Fabio CoppedèDepartment of Translational Research and of New Surgical and Medical Technologies, University of Pisa, Pisa, ItalyCorrespondence: Fabio CoppedèDepartment of Translational Research and of New Surgical and Medical Technologies ...
Coppedè F
doaj   +6 more sources

Inflammation and Premature Ageing in Chronic Kidney Disease [PDF]

Toxins, 2020
Persistent low-grade inflammation and premature ageing are hallmarks of the uremic phenotype and contribute to impaired health status, reduced quality of life, and premature mortality in chronic kidney disease (CKD). Because there is a huge global burden
Thomas Ebert, Sven-Christian Pawelzik, Anna Witasp, Samsul Arefin, Sam Hobson, Karolina Kublickiene, Paul G. Shiels, Magnus Bäck, Peter Stenvinkel   +8 more
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Relationship between biological ageing, premature mortality, life expectancy, and number of live births: a prospective cohort study of the UK women [PDF]

BMC Public Health
Objective There are varying perspectives on the impact of the number of live births on health, and few studies have explored whether the number of live births is associated with female aging.
Huanyu Guo, Yuqing Liu, Ruiming Yang, Xuebing Li, Yubing Teng, Wei Wei, Dandan Zhang   +6 more
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Rare case of longevity in Hutchinson-Gilford progeria syndrome and literature review [PDF]

Orphanet Journal of Rare Diseases
Hutchinson-Gilford progeria syndrome (HGPS) is a rare autosomal dominant disorder characterised by premature ageing, with an average life expectancy of 14.6 years. We report a case of HGPS associated with a typical C. 1824 C > T (P.
Xiao-ling Cai, Hang Chen, Xue-qin Lin, Hong Zhang, Yi-fei Xiang, Ming-xiang Wu, Kai-yang Lin   +6 more
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Population assessment of future trajectories in coronary heart disease mortality. [PDF]

, 2014
Background: Coronary heart disease (CHD) mortality rates have been decreasing in Iceland since the 1980s, largely reflecting improvements in cardiovascular risk factors. The purpose of this study was to predict future CHD mortality in Iceland based on
A Aspelund, B Thorsson, B Unal, B Unal, ES Ford, ES Ford, G Danaei, J Emberson, J Hughes, J Stamler, JA Critchley, JA Critchley, JA Critchley, Julia Critchley, K Bennett, Karl Andersen, L Bjorck, M O'Flaherty, ML Daviglus, MM Finucane, P Bandosz, Rosa Björk Thorolfsdottir, S Allender, S Capewell, S Capewell, S Capewell, S Yusuf, S Yusuf, Simon Capewell, SJ Olshansky, T Aspelund, T Laatikainen, T Leth, Thor Aspelund, Vilmundur Gudnason, VL Roger, Yiru Guo   +36 more
core   +18 more sources

Shared molecular and cellular mechanisms of premature ageing and ageing-associated diseases [PDF]

Nature Reviews Molecular Cell Biology, 2017
Tom Misteli
exaly   +2 more sources

The role of prelamin A post-translational maturation in stress response and 53BP1 recruitment

Frontiers in Cell and Developmental Biology, 2022
Lamin A is a main constituent of the nuclear lamina and contributes to nuclear shaping, mechano-signaling transduction and gene regulation, thus affecting major cellular processes such as cell cycle progression and entry into senescence, cellular ...
Cristina Capanni, Cristina Capanni, Elisa Schena, Elisa Schena, Maria Letizia Di Giampietro, Alessandra Montecucco, Elisabetta Mattioli, Elisabetta Mattioli, Giovanna Lattanzi, Giovanna Lattanzi   +9 more
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Pulmonary Alveolar Stem Cell Senescence, Apoptosis, and Differentiation by p53-Dependent and -Independent Mechanisms in Telomerase-Deficient Mice

Cells, 2021
Pulmonary premature ageing and fibrogenesis as in idiopathic pulmonary fibrosis (IPF) occur with the DNA damage response in lungs deficient of telomerase. The molecular mechanism mediating pulmonary alveolar cell fates remains to be investigated.
Kexiong Zhang, Lihui Wang, Xiaojing Hong, Hao Chen, Yao Shi, Yingying Liu, Jun Liu, Jun-Ping Liu   +7 more
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CD44 connects autophagy decline and ageing in the vascular endothelium

Nature Communications, 2023
The decline of endothelial autophagy is closely related to vascular senescence and disease, although the molecular mechanisms connecting these outcomes in vascular endothelial cells (VECs) remain unclear.
Lu Zhang, Peichang Yang, Jingxuan Chen, Zhiqiang Chen, Zhihui Liu, Gaoqing Feng, Fangfang Sha, Zirui Li, Zaoyi Xu, Yating Huang, Xiaotong Shi, Xuebiao Li, Jiatian Cui, Chenyi Zhang, Pei Fan, Liuqing Cui, Yunpeng Shen, Guangzhou Zhou, Hongjuan Jing, Shiwei Ma   +19 more
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Telomere Attrition in Chronic Kidney Diseases

Antioxidants, 2023
Telomeres are dynamic DNA nucleoprotein structures located at the end of chromosomes where they maintain genomic stability. Due to the end replication problem, telomeres shorten with each cell division.
Tina Levstek, Katarina Trebušak Podkrajšek   +1 more
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