Hutchinson-Gilford progeria syndrome: a rare premature ageing syndrome
Przegląd Dermatologiczny, 2020 Hutchinson-Gilford progeria syndrome is an extremely rare genetic disorder characterized by premature ageing involving the skin, bones, heart, and blood vessels. The incidence is 1 in several million births.
Iti Varshney +5 more
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The emerging role of cellular senescence in renal diseases [PDF]
, 2020 Cellular senescence represents the state of irreversible cell cycle arrest during cell division. Cellular senescence not only plays a role in diverse biological events such as embryogenesis, tissue regeneration and repair, ageing and tumour occurrence ...
Alpini, Gianfranco +12 more
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Frontiers in Medicine, 2021 End-stage renal disease (ESRD) patients exhibit clinical features of premature ageing, including frailty, cardiovascular disease, and muscle wasting. Accelerated ageing also concerns the immune system.
Didier Ducloux +19 more
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Ageing with HIV: Challenges and biomarkers
EBioMedicine, 2022 Summary: The antiretroviral treatment (ART) developed to control HIV infection led to a revolution in the prognosis of people living with HIV (PLWH). PLWH underwent from suffering severe disease and often fatal complications at young ages to having a ...
Berta Rodés +4 more
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Expression of a pathogenic mutation of SOD1 sensitizes aprataxin-deficient cells and mice to oxidative stress and triggers hallmarks of premature ageing [PDF]
, 2014 Aprataxin (APTX) deficiency causes progressive cerebellar degeneration, ataxia and oculomotor apraxia in man. Cell free assays and crystal structure studies demonstrate a role for APTX in resolving 5'-adenylated nucleic acid breaks, however, APTX ...
Bode, David +9 more
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The Changing Narratives of Death, Dying, and HIV in the United Kingdom [PDF]
, 2020 Death and infection were closely linked from the start of the HIV epidemic, until successful treatments became available. The initial impact of mostly young, gay men dying from HIV was powerful in shaping UK responses.
Catalan, J. +9 more
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Uremia causes premature ageing of the T cell compartment in end-stage renal disease patients
Immunity & Ageing, 2012 Background End-stage renal disease (ESRD) patients treated with renal replacement therapy (RRT) have premature immunologically aged T cells which may underlie uremia-associated immune dysfunction.
Meijers Ruud WJ +7 more
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Keap1 governs ageing-induced protein aggregation in endothelial cells
Redox Biology, 2020 The breach of proteostasis, leading to the accumulation of protein aggregates, is a hallmark of ageing and age-associated disorders, up to now well-established in neurodegeneration.
Aleksandra Kopacz +9 more
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What Lies in between Telomere and Organismal Ageing: Comparison between Replicative Senescence and Stress-Induced Premature Senescence [PDF]
E3S Web of Conferences, 2021 A mitotic cell that rests in permanent cell cycle arrest without the ability to divide is considered as a senescent cell. Cellular senescence is essential to limit the function of cells with heavy DNA damages.
Jia Hanyi
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The spectrum of Ischemia-induced white matter injury varies with age [PDF]
, 2013 Stroke is a neurological condition that targets the whole range of the human population, from the pre-term infant to the elderly and is a major cause of death worldwide (Ingall 2004).
Muscat, Richard +2 more
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