Results 251 to 260 of about 94,951 (305)
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Premature Aging and Alcoholism
International Journal of the Addictions, 1982The proposition is frequently put forth in the literature dealing with alcohol abuse that the process which underlies the cognitive impairment found in chronic alcoholics is premature aging of the central nervous system (Fitzhugh et al., 1965; Kish and Cheney, 1969; Goldstein and Shelly, 1971; Smith et al., 1971; Jones and Parsons, 1972; Kleinknecht ...
W R, Leber, O A, Parsons
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Nature Medicine, 2008
Two commonly prescribed drugs, statins and aminobisphosphonates, may be helpful in combating the rare aging disorder, Hutchinson-Gilford progeria syndrome (pages 767–772).
Eran Meshorer, Yosef Gruenbaum
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Two commonly prescribed drugs, statins and aminobisphosphonates, may be helpful in combating the rare aging disorder, Hutchinson-Gilford progeria syndrome (pages 767–772).
Eran Meshorer, Yosef Gruenbaum
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Etiological Factors and Premature Aging
JAMA, 1962AGING IS an interesting subject which is receiving increasing attention in many fields. There is an ever-enlarging body of information which indicates that many of the phenomena which were previously regarded as "natural" processes resulting from old age are actually due to specific disease processes.
J M, KNOX, E G, COCKERELL, R G, FREEMAN
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2012
Hutchinson-Gilford progeria syndrome and Werner syndrome are two of the best characterized human progeroid diseases with clinical features mimicking physiological aging at an early age. Both disorders have been the focus of intense research in recent years since they might provide insights into the pathology of normal human aging.
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Hutchinson-Gilford progeria syndrome and Werner syndrome are two of the best characterized human progeroid diseases with clinical features mimicking physiological aging at an early age. Both disorders have been the focus of intense research in recent years since they might provide insights into the pathology of normal human aging.
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Molecular and Cellular Biochemistry, 2006
Guanidinosuccinic acid is an aberrant metabolite isolated 40 years ago in the blood and urine of uremic subjects and a suspect in the toxicity associated with renal failure. It plays a minor role in the bleeding diathesis of uremia, contributes to the methyl group deficiency of dialysis patients, and is a factor in the premature atherosclerosis of end ...
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Guanidinosuccinic acid is an aberrant metabolite isolated 40 years ago in the blood and urine of uremic subjects and a suspect in the toxicity associated with renal failure. It plays a minor role in the bleeding diathesis of uremia, contributes to the methyl group deficiency of dialysis patients, and is a factor in the premature atherosclerosis of end ...
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2012
Cockayne Syndrome – De Barsy Syndrome – Hallermann-Streiff Syndrome – Hutchinson-Gilford Progeria – Werner ...
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Cockayne Syndrome – De Barsy Syndrome – Hallermann-Streiff Syndrome – Hutchinson-Gilford Progeria – Werner ...
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Science, 2018
Premature Aging Cells from patients with Hutchinson-Gilford progeria syndrome (HGPS) have defects in nuclear architecture that lead to premature cellular senescence. Larrieu et al. investigated the mechanisms by which a small molecule called remodelin improves the phenotype of HGPS cells (see the Focus by Wilson).
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Premature Aging Cells from patients with Hutchinson-Gilford progeria syndrome (HGPS) have defects in nuclear architecture that lead to premature cellular senescence. Larrieu et al. investigated the mechanisms by which a small molecule called remodelin improves the phenotype of HGPS cells (see the Focus by Wilson).
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Growth Hormone and Premature Ageing
Nature, 1973IT has often been suggested that the immune system may be involved in ageing1–4 Fabris et al.5 claim that such immune deficiencies are caused by inadequate stimulation of the lymphoid system by growth hormone (GH). They compared mice with inherited pituitary dwarfism (homozygotes for Snell's dwarf mutation, dw) with normal mice from the same stock. The
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Transcription-coupled repair and premature ageing
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2005During the past decades, several cellular pathways have been discovered to be connected with the ageing process. These pathways, which either suppress or enhance the ageing process, include regulation of the insulin/growth hormone axis, pathways involved with caloric restriction, ROS metabolism and DNA repair.
Andressoo, JO (Jaan-Olle) +1 more
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Human Premature Aging Diseases
2007A number of rare human disorders are associated with distinct clinical features that resemble the aging process at an early stage in life. The study of these conditions has greatly advanced our insight into the aging process. Here, we discuss the clinical and molecular characteristics as well as the recent advances in our insight into the mechanisms of
Dai-Di Gan +3 more
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