Results 51 to 60 of about 94,951 (305)
The telomeric protein AKTIP interacts with A- and B-type lamins and is involved in regulation of cellular senescence [PDF]
, 2016 AKTIP is a shelterin-interacting protein required for replication of telomeric DNA. Here, we show that AKTIP biochemically interacts with A- and B-type lamins and affects lamin A, but not lamin C or B, expression.
Astrologo, Letizia +14 more
core +2 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Hallmarks of progeroid syndromes: lessons from mice and reprogrammed cells
Disease Models & Mechanisms, 2016 Ageing is a process that inevitably affects most living organisms and involves the accumulation of macromolecular damage, genomic instability and loss of heterochromatin.
Dido Carrero +2 more
doaj +1 more source
Actin-Related Protein 4 and Linker Histone Sustain Yeast Replicative Ageing
Cells, 2022 Ageing is accompanied by dramatic changes in chromatin structure organization and genome function. Two essential components of chromatin, the linker histone Hho1p and actin-related protein 4 (Arp4p), have been shown to physically interact in ...
Mateusz Mołoń +11 more
doaj +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Early Vascular Ageing and Cellular Senescence in Chronic Kidney Disease
Computational and Structural Biotechnology Journal, 2019 Chronic kidney disease (CKD) is a clinical model of premature ageing characterized by progressive vascular disease, systemic inflammation, muscle wasting and frailty.
Lu Dai +4 more
doaj +1 more source
T CELL AGING IN RHEUMATOID ARTHRITIS
International Journal of Pharmacy & Integrated Health Sciences, 2022 With the progression of aging, the immune system and the tendency for abnormal immunological changes are common. Individuals over the age of 50 years are susceptible to infectious diseases as well as inflammation and immune-mediated tissue damage. Aging
Maria Oubaid +4 more
doaj +1 more source
Magnesium and other biometals in oxidative medicine and redox biology [PDF]
, 2017 No abstract ...
Barbagallo, Mario +3 more
core +3 more sources
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome
Nature Communications, 2019 The molecular mechanisms of mitochondrial dysfunction in the premature ageing Werner syndrome were elusive. Here the authors show that NAD+ depletion-induced impaired mitophagy contributes to this phenomenon, shedding light on potential therapeutics.
Evandro F. Fang +28 more
doaj +1 more source