Results 51 to 60 of about 214,960 (327)

DNA-Related Pathways Defective in Human Premature Aging

The Scientific World Journal, 2002
One of the major issues in studies on aging is the choice of biological model system. The human premature aging disorders represent excellent model systems for the study of the normal aging process, which occurs at a much earlier stage in life in these ...
Vilhelm A. Bohr
doaj   +1 more source

ON RADIATION-INDUCED AGING: ACCELERATED OR PREMATURE AGING

Radiation Protection Dosimetry, 2022
Abstract The concept of radiation-induced aging is revisited from the viewpoint of a mathematical model. The effect of radiation on carcinogenesis is treated based on the Armitage–Doll multi-stage theory. The formula obtained for cancer incidence rate indicates that radiation dose can be explained in terms of time.
Takahiro Wada, Tetsuhiro Kinugawa, Satoshi Tanaka   +2 more
openaire   +2 more sources

An Analysis for IDH‐Mutant Grade 4 Astrocytoma Based on WHO CNS 5: Implication of Clinical Practice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose There is ongoing debate regarding the therapeutic approach and prognosis for IDH‐mutant grade 4 astrocytoma, a newly defined subtype of diffuse glioma in the 2021 WHO classification system for central nervous system tumors (WHO CNS 5). The aim of this study was to explore the clinical outcome and prognosticators for newly diagnosed IDH‐
Xianxin Qiu, Liping Liang, Lingchao Chen, Pengjie Hong, Wanzun Lin, Jiabing Liu, Zhirui Zhou, Wenjia Zhu, Tianqi Wu, Mingyuan Pan, Yihua Zhong, Jing Gao, Zhiyong Qin, Yang Wang   +13 more
wiley   +1 more source

Prelamin A and ZMPSTE24 in premature and physiological aging

Nucleus, 2023
As human longevity increases, understanding the molecular mechanisms that drive aging becomes ever more critical to promote health and prevent age-related disorders. Premature aging disorders or progeroid syndromes can provide critical insights into aspects of physiological aging.
Howard J. Worman, Susan Michaelis
openaire   +3 more sources

Broadly conserved roles of TMEM131 family proteins in intracellular collagen assembly and secretory cargo trafficking. [PDF]

, 2020
Collagen is the most abundant protein in animals. Its dysregulation contributes to aging and many human disorders, including pathological tissue fibrosis in major organs.
Bai, Meirong, Barbosa, Guilherme Oliveira, Chen, Andrew, Kornberg, Thomas B, Li, Hao, Luo, Shuo, Ma, Dengke K, Sheppard, Dean, Tsukui, Tatsuya, Wang, Bingying, Wang, Xin, Wei, Yuehua, Zhang, Zhe   +12 more
core   +1 more source

C-elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging [PDF]

, 2008
Inclusions in the brain containing alpha-synuclein are the pathological hallmark of Parkinson's disease, but how these inclusions are formed and how this links to disease is poorly understood.
AA Cooper, AB Singleton, AD Gitler, B Rogina, C Hertzman, CD Link, E Berezikov, E Cuppen, EA Nollen, Ellen A. A. Nollen, GM Halliday, HA Tissenbaum, HG van, HH Liou, HM Beere, JF Morley, Karen L. Thijssen, L Chen, M Kaeberlein, M Kaeberlein, M Nishimura, M Viswanathan, MC Chartier-Harlin, MG Spillantini, MG Spillantini, MH Polymeropoulos, NB Cole, PK Auluck, Rainer Breitling, Robert M. W. Hofstra, Ronald H. A. Plasterk, S Kim, S Miksys, S Roy, S Willingham, Stuart K. Kim, T Kai, TF Outeiro, Tjakko J. van Ham   +38 more
core   +8 more sources

Molecular Screening of SCN1A‐Related Seizures in Children With Febrile Seizures: Diagnostic Yield and Variant Distribution

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SCN1A‐related seizures first present as febrile seizures (FS). Definitive features emerge later, making early diagnosis challenging. We evaluated the diagnostic yield and clinical characteristics of pathogenic SCN1A variants in FS, and analyzed the effect of variant characteristics on clinical phenotypes required for early ...
Jia Wang, Yang‐Yang Wang, Lin‐Yan Hu, Xiu‐Yu Shi, Wen He, Dan Sun, Baoguang Li, Xiaoming Liu, Sanqing Xu, Lijun Du, Chunhui Tang, Li‐Ping Zou   +11 more
wiley   +1 more source

p53-sensitive epileptic behavior and inflammation in Ft1 hypomorphic mice [PDF]

, 2018
Epilepsy is a complex clinical condition characterized by repeated spontaneous seizures. Seizures have been linked to multiple drivers including DNA damage accumulation.
Alessandro, Vercelli, Alex Dimitri Bastianelli,, Burla, Romina, Del Giudice, Simona, Di Cunto, Ferdinando, La Torre, Mattia, Marina, Boido, Merigliano, Chiara, Saggio, Isabella, Verni', Fiammetta, Zanetti, Giorgia   +10 more
core   +2 more sources

Remaining Burden of Spinal Muscular Atrophy Among Treated Patients: A Survey of Patients and Caregivers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinal muscular atrophy (SMA) significantly impacts motor function. This study aimed to assess the persistent burden and unmet needs among currently treated patients with SMA and their caregivers. Methods Two complementary web‐based surveys were distributed in August 2024 among patients with SMA and their caregivers.
Julie A. Parsons, Natalie Land, Melissa Culhane Maravic, Claire Cagle, Amal Jamaleddine, Hemal Shah, Thomas Brown, Christabella Cherubino, Mouhamed Gueye   +8 more
wiley   +1 more source

Comprehensive Management of Premature Skin Aging: Current Strategies, Treatments, and Emerging Therapies

Journal of Education, Health and Sport
Introduction and Aim. Premature skin aging results from both intrinsic and extrinsic factors, requiring a comprehensive management strategy. This review evaluates current and emerging approaches for preventing and treating premature skin aging, focusing
Anna Ziobro, Katarzyna Camlet, Kinga Kocur, Paulina Lis   +3 more
doaj   +1 more source