Results 61 to 70 of about 214,960 (327)

Premature aging, allostasis and restorgenesis [PDF]

Spinal Cord, 2013
I feel that the highlight of my research activities is bringing the topic of ‘premature morbidity and aging’ (senectus praecox), in people with spinal cord injury (SCI) and other disabilities, into public awareness ...
openaire   +2 more sources

Cx3cr1-deficient microglia exhibit a premature aging transcriptome. [PDF]

, 2019
CX3CR1, one of the highest expressed genes in microglia in mice and humans, is implicated in numerous microglial functions. However, the molecular mechanisms underlying Cx3cr1 signaling are not well understood.
Allaire, Norm, Burkly, Linda, Challa, Ravi, Cotleur, Anne C, Cullen, Patrick, Glass, Christopher K, Gosselin, David, Gyoneva, Stefka, Hosur, Raghavendra, Miao, Kelly, Ouyang, Zhengyu, Peterson, Michael, Ransohoff, Richard M, Reynolds, Taylor L, Roberts, Chris, Zhang, Baohong   +15 more
core  

Tissue-specific suppression of thyroid hormone signaling in various mouse models of aging [PDF]

, 2016
DNA damage contributes to the process of aging, as underscored by premature aging syndromes caused by defective DNA repair. Thyroid state changes during aging, but underlying mechanisms remain elusive.
Barnhoorn, S. (Sander), Boelen, A. (Anita), Bombardieri, C.R. (Cíntia R.), Brandt, R.M.C. (Renata), Darras, V.M. (Veerle), Dollé, M.E.T. (Martijn), Garinis, G.A. (George), Heerebeek, R. (Ramona) van, Hoeijmakers, J.H.J. (Jan), Horst, G.T.J. (Gijsbertus) van der, Kaptein, E. (Ellen), Kopchick, J.J. (John ), Krijger, R.R. (Ronald) de, Kwakkel, J. (Joan), List, E.O. (Edward O.), Medici, M. (Marco), Melis, J.P.M. (Joost), Ottaviani, A. (Alexandre), Peeters, R.P. (Robin), Pluijm, I. (Ingrid) van der, Toor, H. (Hans) van, Van Ham, W. (Willy), Vermeij, W.P. (Wilbert), Visser, T.J. (Theo), Visser, W.E. (Edward), Waard, M.C. (Monique) de, Zevenbergen, C. (Chantal)   +26 more
core   +1 more source

Association of the ICH Score With Withdrawal of Life‐Sustaining Treatment Over a 10‐Year Period

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The intracerebral hemorrhage (ICH) score was developed to enhance provider communication and facilitate early severity assessment. We examined the association of the ICH score with mortality and withdrawal of life‐sustaining treatment (WLST) in a large, multicenter stroke registry, and evaluated temporal trends in these associations.
Nina Massad, Lili Zhou, Brian Manolovitz, Negar Asdaghi, Hannah Gardener, Hao Ying, Carolina M. Gutierrez, Angus Jameson, David Rose, Mohan Kottapally, Amedeo Merenda, Kristine O'Phelan, Sebastian Koch, Jose G. Romano, Tatjana Rundek, Ayham Alkhachroum   +15 more
wiley   +1 more source

On occupational factors and premature aging (literature review)

Сибирский научный медицинский журнал
Quantitative characteristics of the impact of factors of the production environment (physical, chemical, biological), the severity and intensity of the labor process, their contribution to the deterioration of the health of the working contingent and the
O. A. Savchenko, I. I. Novikova, O. V. Plotnikova   +2 more
doaj   +1 more source

The role of peroxisome proliferator-activated receptor-coactivator-1 gene in skin aging

Journal of Research in Medical Sciences, 2016
Skin aging is a continuous process that exhibits fine and deep wrinkles, thin and transparent skin, loss of underlying fat, dry skin and itch, following decreased collagen and elastin synthesis.
Shahrzad Aghaei, Mohammad Ali Nilforoushzadeh, Maryam Aghaei   +2 more
doaj   +1 more source

Mutations Involved in Premature-Ageing Syndromes

The Application of Clinical Genetics, 2021
Premature-ageing syndromes are a heterogeneous group of rare genetic disorders resembling features of accelerated ageing and resulting from mutations in genes coding for proteins required for nuclear lamina architecture, DNA repair and maintenance of genome stability, mitochondrial function and other cellular processes.
openaire   +7 more sources

Vascular Smooth Muscle-Specific Progerin Expression Accelerates Atherosclerosis and Death in a Mouse Model of Hutchinson-Gilford Progeria Syndrome [PDF]

, 2018
Background: Progerin, an aberrant protein that accumulates with age, causes the rare genetic disease Hutchinson-Gilford progeria syndrome (HGPS). Patients who have HGPS exhibit ubiquitous progerin expression, accelerated aging and atherosclerosis, and ...
Andrés Manzano, María J., Andrés, Vicente, Bentzon, Jacob F., Gonzalo, Pilar, Hamczyk, Magda Rita, López Otín, Carlos, Nogales, Paula, Villa Bellosta, Ricardo   +7 more
core   +4 more sources

Analysis of the Longitudinal Behavior of Serum Levels of Soluble Flt1 and Placental Growth Factor in Pregnant Patients With Systemic Lupus Erythematosus

Arthritis Care &Research, EarlyView.
Objective This study analyzed longitudinal trajectories of soluble Flt1 (sFlt1) levels, placenta growth factor (PlGF) levels, and sFlt1:PlGF ratios in a cohort of pregnant patients with systemic lupus erythematosus (SLE). Methods Blood samples were collected (14–18, 24–26, 30–32, 34–36, and 38–40 weeks), stored at −80°C, and evaluated for serum levels ...
Nilson R. de Jesús, Guilherme R. de Jesús, Marcela I. Lacerda, Flávia C. dos Santos, Jeane de S Nogueira, Luiz Cristóvão Porto, Evandro S. F. Coutinho, Evandro M. Klumb   +7 more
wiley   +1 more source

Benign prostatic hyperplasia in a 23 year old man with progeroid syndrome

African Journal of Urology, 2018
Introduction: Progeroid syndromes are characterized by accelerated aging and early development of diseases typically associated with aging. Premature development of tumors including BPH, maybe observed in these patients, which can lead to significant ...
M. Ahmed, A.T. Lawal, A. Bello, A. Abubakar, H.Y. Maitama   +4 more
doaj