Results 31 to 40 of about 21,624 (243)

The need to identify novel biomarkers for prediction of premature ovarian insufficiency (POI)

Middle East Fertility Society Journal, 2022
Background Premature ovarian failure (POF)/premature ovarian insufficiency (POI) is characterized by disrupting ovarian function under 40 years old. A major health problem of this disorder is female infertility. There are no proven treatments to increase
Roya Kabodmehri, Seyedeh Hajar Sharami, Zahra Rafiei Sorouri, Nasrin Ghanami Gashti   +3 more
doaj   +1 more source

SIRT5-RAC2 Axis Drives Monocyte-to-Macrophage Differentiation to Promote Inflammatory Injury in Premature Ovarian Insufficiency. [PDF]

Adv Sci (Weinh)
SIRT5 desuccinylates and stabilizes RAC2, activating CSF1R‐dependent signaling to drive monocyte differentiation into M0 macrophages and their polarization toward pro‐inflammatory M1 phenotypes in CTX‐induced premature ovarian insufficiency. Inhibiting the SIRT5‐RAC2 axis attenuates inflammation, reduces granulosa cell apoptosis, and preserves ...
TanTai W, Li Y, Liu S, Wu M, Liu Z, Jiang J, Chen J, Xu X, Li L, Li C, Zhao F, Liu Y, Ni H, Zhang T, Xu M, Han C.   +15 more
europepmc   +2 more sources

Cardiometabolic health in premature ovarian insufficiency [PDF]

Climacteric, 2021
Premature ovarian insufficiency (POI) is an increasing public health problem with a prevalence now approaching 4%. POI results in adverse effects on the skeleton and central nervous system as well as disturbances of metabolic and cardiological factors that predispose to a major increased risk of cardiovascular disease (CVD).
J. C. Stevenson, P. Collins, H. Hamoda, I. Lambrinoudaki, A. H. E. M. Maas, K. Maclaran, N. Panay   +6 more
openaire   +3 more sources

Regulation of reproduction via tight control of gonadotropin hormone levels. [PDF]

, 2018
Mammalian reproduction is controlled by the hypothalamic-pituitary-gonadal axis. GnRH from the hypothalamus regulates synthesis and secretion of gonadotropins, LH and FSH, which then control steroidogenesis and gametogenesis. In females, serum LH and FSH
Coss, Djurdjica
core   +1 more source

How polymorphic markers contribute to genetic diseases in different populations? The study of inhibin A for premature ovarian insufficiency

Einstein (São Paulo)
Objective To verify the incidence of the G679A mutation in exon 2 of the gene inhibin alpha (INHA), in women with secondary amenorrhea and diagnosis of premature ovarian insufficiency, and in controls.
Denise Maria Christofolini, Emerson Barchi Cordts, Fernando Santos-Pinheiro, Erika Azuma Kayaki, Mayla Cristina Fernandes Dornas, Monise de Castro Santos, Bianca Bianco, Caio Parente Barbosa   +7 more
doaj   +1 more source

Defining ovarian reserve to better understand ovarian aging [PDF]

, 2011
Though a widely utilized term and clinical concept, ovarian reserve (OR) has been only inadequately defined. Based on Medline and PubMed searches we here define OR in its various components, review genetic control of OR, with special emphasis on the FMR1
Norbert Gleicher, Andrea Weghofer, David H Barad   +2 more
core   +1 more source

Expression profiles of miR-23a and miR-146a in the peripheral blood of women with premature ovarian insufficiency

Einstein (São Paulo)
Objective This study aimed to analyze the expression profiles of miR-23a and miR-146a in women with premature ovarian insufficiency and to evaluate their value as biomarkers of the disease for early diagnosis and prognosis, as well as effective ...
Thérèse Rachell Theodoro, Rafael Bitelman Barreiro, Isabella Verdi Cunha, Bianca Bianco, Caio Parente Barbosa, Denise Maria Christofolini   +5 more
doaj   +1 more source

Novel bone morphogenetic protein 15 (BMP15) gene variants implicated in premature ovarian insufficiency

Reproductive Biology and Endocrinology, 2022
Background Bone morphogenetic protein 15 (BMP15) is expressed in oocytes and plays a crucial role in the reproduction of mono-ovulating species. In humans, BMP15 gene mutations lead to imperfect protein function and premature ovarian insufficiency.
Fatemeh Afkhami, Shirin Shahbazi, Laya Farzadi, Shahla Danaei   +3 more
doaj   +1 more source

Associations Between BMI, Serum Hormone Levels, Time Since Ovarian Insufficiency Onset, Serologic Autoimmunity, and Prevalence of Common Parameters: A cross-sectional Retrospective Study of Premature Ovarian Insufficiency

Biomedical Sciences and Clinical Medicine, 2023
OBJECTIVE Premature ovarian insufficiency (POI) affects 1:100 women before the age of 40. The objectives include exploring correlations between body mass index, years since the onset of premature ovarian insufficiency, follicular ...
Kitirat Techatraisak, Prasong Tanmahasamut, Suchada Indhavivadhana, Thanyarat Wongwananuruk, Manee Rattanachaiyanont, Chongdee Dangrat   +5 more
doaj   +1 more source

Vaccines in Current Culture: The HPV Vaccine Controversy [PDF]

, 2020
The use of vaccinations has drastically decreased mortality and morbidity rates related to infectious disease and has become an intrinsic part of modern health care.
Johnston, Alyssa
core   +1 more source