Results 61 to 70 of about 21,624 (243)

Premature Ovarian Insufficiency: Past, Present, and Future

Frontiers in Cell and Developmental Biology, 2021
Premature ovarian insufficiency (POI) is the loss of normal ovarian function before the age of 40 years, a condition that affects approximately 1% of women under 40 years old and 0.1% of women under 30 years old.
Seung Joo Chon, Zobia Umair, Mee-Sup Yoon, Mee-Sup Yoon, Mee-Sup Yoon   +4 more
doaj   +1 more source

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

Plasma metabolomic characterization of premature ovarian insufficiency

Journal of Ovarian Research, 2023
Background Premature ovarian insufficiency (POI) patients are predisposed to metabolic disturbances, including in lipid metabolism and glucose metabolism, and metabolic disorders appear to be a prerequisite of the typical long-term complications of POI ...
Xing-Yu Zhou, Xin Li, Jun Zhang, Ying Li, Xiao-Min Wu, Yi-Zhen Yang, Xiao-Fei Zhang, Lin-Zi Ma, Yu-Dong Liu, Zhe Wang, Shi-Ling Chen   +10 more
doaj   +1 more source

A novel homozygous mutation of the AIRE gene in an APECED patient from Pakistan: case report and review of the literature [PDF]

, 2018
Autoimmune-poly-endocrinopathy-candidiasis-ectodermal-dystrophy syndrome (APECED) is a rare monogenic recessive disorder caused by mutations in the autoimmune regulator (AIRE) gene.
Bellacchio, Emanuele, Betterle, Corrado, Dhamo, Rudina, Fierabracci, Alessandra, Frasca, Federica, Pellegrino, Marsha   +5 more
core   +2 more sources

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

DOES OVARIAN AUTOIMMUNITY PLAY A ROLE IN THE PATHPHYSIOLOGY OF PREMATURE OVARIAN INSUFFICIENCY [PDF]

, 2014
Premature ovarian failure (POF) is a term usually used to describe women younger than 40 years of age who present with amenorrhea. Diagnosis of POF is on the basis of follicle stimulating hormone level in the menopausal range associated with amenorrhea ...
Bakun, Oxana, Sekeiros Peres, Krize, Voitko, Maryna   +2 more
core  

FMR1 expression in human granulosa cells increases with exon 1 CGG repeat length depending on ovarian reserve [PDF]

, 2018
Background: Fragile-X-Mental-Retardation-1- (FMR1)-gene is supposed to be a key gene for ovarian reserve and folliculogenesis. It contains in its 5’-UTR a triplet-base-repeat (CGG), that varies between 26 and 34 in general population.
Alcoba, Diego D., Brum, Ilma S., Dietrich, Jens E., Freis, Alexander, Germeyer, Ariane, Hinderhofer, Katrin, Messmer, Birgitta, Rehnitz, Julia, Strowitzki, Thomas, Youness, Berthe   +9 more
core   +2 more sources

Extracellular Vesicles in Autoimmune Diseases: From Diagnostic Biomarkers to Engineered Therapeutics

Advanced Science, EarlyView.
This review provides a systematic comparison of extracellular vesicles (EVs) from both mammalian and plant sources in the context of autoimmune diseases. It highlights their emerging roles as precision biomarkers and engineered therapeutic platforms.
Yufei Wu, Huiyuan Ma, Tinghui Zhu, Shuwei Huang, Manxi Lu, Qiong Wang, Zai‐Long Chi   +6 more
wiley   +1 more source

Premature ovarian insufficiency: When ovaries retire early

Annals, Academy of Medicine, Singapore
Introduction: Premature ovarian insufficiency (POI) refers to loss of ovarian activity before the age 40 years. POI has significant detrimental effects on health (infertility, cardiovascular diseases, type 2 diabetes, reduced bone density, dementia ...
Stella Rizalina Sasha Sugianto, Lisa Webber, Farah Husain Safdar, Veronique Viardot-Foucault, Sadhana Nadarajah, Jiin Ying Lim, Ee Shien Tan, Tze Tein Yong, Rukshini Puvanendran   +8 more
doaj   +1 more source

Meiotic Recombination Defects and Premature Ovarian Insufficiency

Frontiers in Cell and Developmental Biology, 2021
Premature ovarian insufficiency (POI) is the depletion of ovarian function before 40 years of age due to insufficient oocyte formation or accelerated follicle atresia. Approximately 1–5% of women below 40 years old are affected by POI.
Chengzi Huang, Chengzi Huang, Chengzi Huang, Chengzi Huang, Ting Guo, Ting Guo, Ting Guo, Ting Guo, Yingying Qin, Yingying Qin, Yingying Qin, Yingying Qin   +11 more
doaj   +1 more source