Results 51 to 60 of about 148,668 (256)

Cognitive and behavioral clinical outcome assessments in children with developmental and epileptic encephalopathies: Issues and instruments

Epilepsia, EarlyView.
Abstract Children with developmental and epileptic encephalopathies (DEEs) face cognitive and behavioral challenges that may have a greater impact than seizures on their quality of life (QoL). The need to assess these nonseizure outcomes for evaluating treatments is increasingly recognized.
Cinzia Correale, Nicola Specchio, Jenny Downs, J. Helen Cross, Simona Cappelletti, Andrea Palacio‐Navarro, Sam Geuens, Kette Valente, Andreas Brunklaus, Colin Reilly   +9 more
wiley   +1 more source

Add‐on treatment with vinpocetine reduces seizure frequency and improves comorbidities in patients with loss‐of‐function γ‐aminobutyric acid type A receptor variants

Epilepsia, EarlyView.
Abstract Objective The semisynthetic compound vinpocetine has gained attention as a potential precision medicine for developmental and epileptic encephalopathies caused by loss‐of‐function (LoF) variants in γ‐aminobutyric acid type A (GABAA) receptor genes. As a positive allosteric modulator of GABAA receptors, case reports suggest that vinpocetine can
Cathrine E. Gjerulfsen, Vivian W. Y. Liao, Tomasz S. Mieszczanek, Anne V. Jakobsen, Elena Gardella, Kern Olofsson, Marina Nikanorova, Allan Bayat, Sebastian Ortiz, Sarah Weckhuysen, Cecilie Johannessen Landmark, Orrin Devinsky, Mary Chebib, Philip K. Ahring, Guido Rubboli, Rikke S. Møller   +15 more
wiley   +1 more source

Insights into ANKRD11‐related epilepsy from 163 people

Epilepsia, EarlyView.
Abstract Objective Ankyrin repeat domain 11 gene (ANKRD11) is the key disease gene for autosomal dominant KBG syndrome, and a subset of affected individuals develop epilepsy. However, comprehensive characterization of epilepsy‐related phenotypes and genotype–phenotype correlations in ANKRD11 variant carriers remains limited.
Song Su, Jian Ma, Qi Zhang, Wandong Hu, Ying Ren, Wenchao Zhang, Hongwei Zhang   +6 more
wiley   +1 more source

Climate change amplifies global mycotoxin exposure: Emerging risks and sustainable solutions

iMetaOmics, EarlyView.
Climate change intensifies mycotoxin contamination through rising temperatures, elevated CO2, and altered precipitation. Global surveys reveal a high and widespread prevalence of major mycotoxins in staple cereals, with low‐income countries bearing the greatest burden.
Mengyao Xue, Zheng Qu, Tingting Jiang, Antonio F. Logrieco, Antonio Moretti, Ke Dong, Yanpo Yao, Qi Zhang, Peiwu Li   +8 more
wiley   +1 more source

Investigation of the Relationship Between Sensory Processing Skills and Language Development in Children With Developmental Language Disorders

Brain and Behavior
Background The aim was to compare the sensory processing skills of children diagnosed with developmental language disorder (DLD) with those of typically developing children and to investigate the relationship between language development and sensory ...
Elife Barmak, Banu Baş
doaj   +1 more source

Pediatric Systemic Lupus Erythematosus Complicated by Acute EBV and CMV Co‐infection

Journal of Clinical Laboratory Analysis, EarlyView.
This case report describes a 10‐year‐old girl with new‐onset pediatric SLE who presented with malar rash, fever, and arthritis following sun exposure, alongside serological evidence of acute Epstein–Barr virus (EBV) and cytomegalovirus (CMV) co‐infection.
Anning Chen, Gengchun Ji, Ziping Lan, Ping Li, Jianwei Wang, Le Zhang, Chaojun Hu, Shulan Zhang   +7 more
wiley   +1 more source

The Use of Digital Technology by Parents from the Perspective of Children

Turkish Academic Research Review
This study is a qualitative research project aimed at examining preschool children's perceptions and views of their parents' use of digital technology.
Emine Ela Şimşek
doaj   +1 more source

Failure to replicate effects of parent‐delivered early language intervention: Evidence from a randomised controlled trial with implications for universal language intervention

JCPP Advances, EarlyView.
Abstract Background Parent‐led, preschool language interventions may help to mitigate the risk of poor language and literacy outcomes associated with lower socioeconomic status. This study builds on two previous evaluations of a parent‐led early language teaching programme, which demonstrated mixed findings.
Kelly Burgoyne, Laura Boundy, Paivi Eerola, Qing Zhang, Jochen Einbeck, Helen Cramman, Vic Menzies   +6 more
wiley   +1 more source

The development of specific emotion comprehension components in 1285 preschool children

Scientific Reports
The goal was to examine the development of specific components of emotion comprehension in 1285 preschool children aged 3 to 5 years. Three tasks were used: context-free facial recognition of four primary (and neutral) emotions, and comprehension of ...
Sylvie Richard, Thalia Cavadini, Nathalie Dalla-Libera, Sonia Angonin, Laura Alaria, Anne Lafay, Carole Berger, Edouard Gentaz   +7 more
doaj   +1 more source

Trajectories of child emotional and behavioural difficulties before and during the COVID‐19 pandemic in a longitudinal UK cohort

JCPP Advances, EarlyView.
Abstract Background There are substantial age‐related changes in emotional and behavioural problems over childhood. In order to establish the impact of the Covid‐19 pandemic on child emotional and behavioural problems, longitudinal designs which take into account age‐related trends are needed.
Nicky Wright, Daphne Kounali, Elise Paul, Alex S. F. Kwong, Daniel Major‐Smith, Ilaria Costantini, Deborah A. Lawlor, Kapil Sayal, Helen Bould, Nicholas J. Timpson, Kate Northstone, Melanie Lewcock, Kate Tilling, Rebecca M. Pearson   +13 more
wiley   +1 more source