Results 91 to 100 of about 22,628 (189)

In Silico Phosphoproteomic Analysis Reveals Divergent Regulation of Presenilin 1 and Presenilin 2. [PDF]

Neuromolecular Med
Begum S, De Alvarez JA, Manzoni C, Arber C, Lewis PA.   +4 more
europepmc   +1 more source

From mechanistic modeling to AI-driven design: computational strategies for targeting the γ-secretase complex. [PDF]

Brief Bioinform
Das S, Rao Padubidri S, K V S, Shetty KS, Jena R, K R H, Dehury B, Pandurangan AP.   +7 more
europepmc   +1 more source

Increasing expression of presenilin 1, β-catenin, and p-PTEN and its regulatory roles on cell invasion in gastric cancer. [PDF]

World J Gastrointest Oncol
Lin X, Lin GF, Gu FT, Li YL.
europepmc   +1 more source

Signaling abnormality leading to excessive/aberrant synaptic plasticity in Alzheimer's disease

Frontiers in Aging Neuroscience, 2022
Shigeki Kawabata
doaj   +1 more source

Early onset Alzheimer's disease with V180I variant of prion protein gene and a family history of dementia: a case report. [PDF]

BMC Neurol
Hamaguchi T, Hamano T, Senoh T, Kawasaki Y, Uehara T, Satoh K, Hara N, Miyashita A, Ikeuchi T, Kitamoto T, Asahina M.   +10 more
europepmc   +1 more source

Stress Accelerates Depressive-Like Behaviors through Increase of Notch2 Expression in N141I Mutation Presenilin-2 Transgenic Mice. [PDF]

Biomol Ther (Seoul)
Yoo SS, Gu SM, Nam KT, Choi JS, Lee YS, Yeo IJ, Yu JE, Kim S, Lee DW, Ham HJ, Chang JY, Yun J, Son DJ, Han SB, Hong JT.   +14 more
europepmc   +1 more source

Presenilin mutations disrupt iron homeostasis to promote ferroptosis mediated neurodegeneration in Caenorhabditis elegans. [PDF]

Redox Biol
Ryan KC, Laboy JT, Ashraf R, Ashkavand Z, Jayasinghe I, Norman KR.   +5 more
europepmc   +1 more source

ZL006 Treatment Reduces Inflammation, Oxidative Stress, and Brain Aβ_1-42 Accumulation and Rescues the Loss of PSD95 Synaptic Marker in Familial Alzheimer's Disease-Associated <i>psen1</i>-Deficient Zebrafish Model. [PDF]

Int J Mol Sci
Ricci S, Benuzzi M, Fazzina M, Cacialli P.   +3 more
europepmc   +1 more source

Neuroinflammation and Secretase Regulation in Alzheimer's Disease: From Molecular Cross-Talk to Multi-Target Therapeutics. [PDF]

Int J Mol Sci
Cipriano GL, Anchesi I, Raffaele I, Astorino MF, Minuti A, Calabrò M, Crisafulli C.   +6 more
europepmc   +1 more source

Presenilin Loss Impairs Synaptic Transmission and Causes Axonal Degeneration through Ryanodine Receptor Dysfunction, Independent of γ-Secretase Activity. [PDF]

J Neurosci
Du X, Niu L, Ragan M, Fracz Z, Wang ZW.
europepmc   +1 more source